PTFE-Membrane Flow Reactor for Aerobic Oxidation Reactions and Its Application to Alcohol Oxidation

Greene, Jodie F.; Preger, Yuliya; Stahl, Shannon S.; Root, Thatcher W.

doi:10.1021/acs.oprd.5b00125

Cited by 59 publications

(41 citation statements)

References 51 publications

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“…A membrane flow reactor was constructed using permeable PTFE for aerobic oxidation of alcohol. Among other materials, PTFE excellently proved its ability to stand in more reaction steps and to sustain at elevated temperatures [72].…”

Section: Ptfe In Biomedical and Pharmaceutical Applicationsmentioning

confidence: 99%

Performance properties and applications of polytetrafluoroethylene (PTFE)—a review

Dhanumalayan

Joshi

2018

Adv Compos Hybrid Mater

342

143

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High-performance commodity polymers are in demand due to low cost, durability, easy productivity, and recycling ability. This article comprises a survey on the performance properties of polytetrafluoroethylene (PTFE) fluoropolymer. It is a well-known choice for coatings, insulation, thermal sealing, lubrication, bearings, and clinical applications. PTFE was engineered in many forms as a function of loading nano and micro fillers for different purposes and the improved properties and performance were addressed by the researchers. Hence, we disclosed the various casting routes of PTFE which is feasible for reliable processing to serve in domestic and industrial applications.

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Section: Ptfe In Biomedical and Pharmaceutical Applicationsmentioning

confidence: 99%

Performance properties and applications of polytetrafluoroethylene (PTFE)—a review

Dhanumalayan

Joshi

2018

Adv Compos Hybrid Mater

342

143

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“…Tube-in-tube membrane reactors show great potential to avoid the formation of explosive mixtures, but still have inherent scalability issues for large-scale synthesis. 21,27 Implementing the thin-layer membrane reactor designed in this work offers the opportunity to make the aerobic oxidation reactions both safe and scalable for industrial applications.…”

Section: Homogeneous Cu/tempo Catalyzed Aerobic Alcohol Oxidationsmentioning

confidence: 99%

Scalable thin-layer membrane reactor for heterogeneous and homogeneous catalytic gas–liquid reactions

Imbrogno

Zhang

et al. 2018

Green Chem.

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Catalytic gas-liquid reactions have potential as environmentally benign methods for organic synthesis, particularly hydrogenation and oxidation reactions. However, safety and scalability are concerns in the application of gas-liquid reactions. In this work, we develop and demonstrate a scalable, sustainable, and safe thin-layer membrane reactor for heterogeneous Pd-catalyzed hydrogenations and homogenous Cu(I)/TEMPO alcohol oxidations. The implementation of a Teflon amorphous fluoroplastic (AF) membrane and porous carbon cloth in the membrane reactor provides sufficient gas-liquid mass transfer to afford superior performance compared to conventional packed-bed or trickle-bed reactors. The membrane separates the gas from the liquid, which avoids the formation of explosive mixtures for oxygenation reactions and simplifies the two-phase hydrodynamics to facilitate scale-up by stacking modules, while significantly reducing gas consumption. In addition, 3-dimensional simulations deliver insights into the mass transfer and hydrodynamic behavior to inform optimal membrane reactor design and operation.

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“…Root and colleagues used this copper-catalyzed protocol to test an inexpensive variant of the tube-in-tube reactor by utilizing simple PTFE instead of the costly Teflon AF-2400 as gas-permeable membrane material [111]. Their reactor design consisted of a PTFE tubing coiled into a stainless steel shell (tube in shell, Scheme 13).…”

Section: Homogeneous Catalysismentioning

confidence: 99%

Aerobic Oxidations in Continuous Flow

Pieber

Kappe

2015

Organometallic Flow Chemistry

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In recent years, the high demand for sustainable processes resulted in the development of highly attractive oxidation protocols utilizing molecular oxygen or even air instead of more uneconomic and often toxic reagents. The application of these sustainable, gaseous oxidants in conventional batch reactors is often associated with severe safety risks and process challenges especially on larger scales. Continuous flow technology offers the possibility to minimize these safety hazards and concurrently allows working in high-temperature/high-pressure regimes to access highly efficient oxidation protocols. This review article critically discusses recent literature examples of flow methodologies for selective aerobic oxidations of organic compounds. Several technologies and reactor designs for biphasic gas/liquid as well as supercritical reaction media are presented in detail.

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PTFE-Membrane Flow Reactor for Aerobic Oxidation Reactions and Its Application to Alcohol Oxidation

Cited by 59 publications

References 51 publications

Performance properties and applications of polytetrafluoroethylene (PTFE)—a review

Performance properties and applications of polytetrafluoroethylene (PTFE)—a review

Scalable thin-layer membrane reactor for heterogeneous and homogeneous catalytic gas–liquid reactions

Aerobic Oxidations in Continuous Flow

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