PTP1B knockdown alleviates BMSCs senescence via activating AMPK-mediated mitophagy and promotes osteogenesis in senile osteoporosis

Yang, QianKun; Zou, YuChi; Wei, Xiaoyu; Ye, Peng; Wu, Yutong; Ai, HongBo; Zhao, Zhiling; Tan, Jiulin; Zhou, Jiangling; Yang, Yusheng; Dai, Qijie; Dou, Ce; Luo, Fei

doi:10.1016/j.bbadis.2023.166795

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

2023

DOI: 10.1016/j.bbadis.2023.166795

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PTP1B knockdown alleviates BMSCs senescence via activating AMPK-mediated mitophagy and promotes osteogenesis in senile osteoporosis

QianKun Yang

YuChi Zou

Xiaoyu Wei

et al.

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Cited by 7 publications

References 87 publications

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Targeting Mitophagy as a Potential Therapeutic Approach for Age‐Related Bone Diseases

Zhang,

Li,

Zhang

et al. 2024

Advanced Therapeutics

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Accumulating evidence has suggested a strong correlation between age‐related bone diseases and abnormal metabolism of bone microenvironment‐related cells, including mesenchymal stem cells (MSCs), osteoblasts, osteoclasts, osteocytes, and chondrocytes. Mitochondrial dysfunction significantly impacts cell metabolism and initiates the development and progress of numerous age‐related bone diseases. Mitochondrial autophagy or mitophagy, a process that selectively removes damaged or dysfunctional mitochondria, is closely associated with maintaining mitochondrial quality control and homeostasis. Recent studies indicate a decisive regulatory role of mitophagy in age‐related bone diseases, thereby pointing toward the potential for manipulating mitophagy levels as a new treatment paradigm. Based on the importance and novelty of mitophagy, the present review offers an overview of the pathways involved in mitophagy and meticulously examines its function in age‐related bone diseases. Various treatment methods targeting mitophagy are also discussed, mainly including biomaterials with mitophagy‐modulatory capabilities, “old drugs in a new bottle” (e.g., Metformin, Rapamycin), natural compounds, endogenous factors, and stem cell‐based therapies. In conclusion, these innovative approaches uncover mitophagy‐related signals, pathways, and mechanisms, and may shed light on mitophagy‐targeting treatments for age‐related bone diseases in the future.

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Targeting Mitophagy as a Potential Therapeutic Approach for Age‐Related Bone Diseases

Zhang,

Li,

Zhang

et al. 2024

Advanced Therapeutics

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The Role of PKM2 in Multiple Signaling Pathways Related to Neurological Diseases

Zhang,

Lei,

Zhou

et al. 2023

Mol Neurobiol

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GDF11 promotes osteogenic/odontogenic differentiation of dental pulp stem cells to accelerate dentin restoration via modulating SIRT3/FOXO3-mediated mitophagy

Deng,

Tang,

et al. 2024

International Immunopharmacology

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PTP1B knockdown alleviates BMSCs senescence via activating AMPK-mediated mitophagy and promotes osteogenesis in senile osteoporosis

Cited by 7 publications

References 87 publications

Targeting Mitophagy as a Potential Therapeutic Approach for Age‐Related Bone Diseases

Targeting Mitophagy as a Potential Therapeutic Approach for Age‐Related Bone Diseases

The Role of PKM2 in Multiple Signaling Pathways Related to Neurological Diseases

GDF11 promotes osteogenic/odontogenic differentiation of dental pulp stem cells to accelerate dentin restoration via modulating SIRT3/FOXO3-mediated mitophagy

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