PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET

Dong, Hongmei; Lin, Wan-Wan; Du, Liqun; Yao, Ziting; Luo, Yichen; Li, Feifei; Chen, Shuanglong; Huang, Yiteng; Ren, Hongzheng; Cai, Song-Wang; Chen, Yexi; Tang, Hui; Qiu, Xiaoyu; Pan, Yunlong; Huang, Xingxu; Zhang, Dianzheng; Gao, Shegan; Yeung, Sai‐Ching Jim; Zhang, Hao

doi:10.1016/j.canlet.2023.216283

Cited by 6 publications

(3 citation statements)

References 45 publications

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Section: Protein Tyrosine Phosphatase Receptor Type O (Ptpro)mentioning

confidence: 99%

“…PTPRO has tumor suppressive role in several cancers [255,256]. The downregulation of PTPRO in cancers results from its epigenetic silencing, caused by hypermethylation of the promoter region of the PTPRO encoding gene [255,256]. Upregulating PTPRO expression in tumors, such as esophageal squamous cell carcinoma, breast, and colorectal cancers, has tumor-suppressive effects by preventing tumor growth and metastases.…”

Section: Protein Tyrosine Phosphatase Receptor Type O (Ptpro)mentioning

confidence: 99%

“…Upregulating PTPRO expression in tumors, such as esophageal squamous cell carcinoma, breast, and colorectal cancers, has tumor-suppressive effects by preventing tumor growth and metastases. These positive effects may be a ributed to induced apoptosis and suppressed tumor-associated angiogenesis [255][256][257]. Research in colorectal cancer has revealed that PTPRO can associate with erb-b2 receptor tyrosine kinase 2 (ERBB2), thereby inhibiting signaling pathways and obstructing tumor growth [255].…”

Section: Protein Tyrosine Phosphatase Receptor Type O (Ptpro)mentioning

confidence: 99%

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Role of Protein Phosphatases in Tumor Angiogenesis: Assessing PP1, PP2A, PP2B and PTPs Activity

Fonódi,

Nagy,

Boratkó

2024

IJMS

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Tumor angiogenesis, the formation of new blood vessels to support tumor growth and metastasis, is a complex process regulated by a multitude of signaling pathways. Dysregulation of signaling pathways involving protein kinases has been extensively studied, but the role of protein phosphatases in angiogenesis within the tumor microenvironment remains less explored. However, among angiogenic pathways, protein phosphatases play critical roles in modulating signaling cascades. This review provides a comprehensive overview of the involvement of protein phosphatases in tumor angiogenesis, highlighting their diverse functions and mechanisms of action. Protein phosphatases are key regulators of cellular signaling pathways by catalyzing the dephosphorylation of proteins, thereby modulating their activity and function. This review aims to assess the activity of the protein tyrosine phosphatases and serine/threonine phosphatases. These phosphatases exert their effects on angiogenic signaling pathways through various mechanisms, including direct dephosphorylation of angiogenic receptors and downstream signaling molecules. Moreover, protein phosphatases also crosstalk with other signaling pathways involved in angiogenesis, further emphasizing their significance in regulating tumor vascularization, including endothelial cell survival, sprouting, and vessel maturation. In conclusion, this review underscores the pivotal role of protein phosphatases in tumor angiogenesis and accentuate their potential as therapeutic targets for anti-angiogenic therapy in cancer.

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Section: Protein Tyrosine Phosphatase Receptor Type O (Ptpro)mentioning

confidence: 99%

Section: Protein Tyrosine Phosphatase Receptor Type O (Ptpro)mentioning

confidence: 99%

Section: Protein Tyrosine Phosphatase Receptor Type O (Ptpro)mentioning

confidence: 99%

See 1 more Smart Citation

Role of Protein Phosphatases in Tumor Angiogenesis: Assessing PP1, PP2A, PP2B and PTPs Activity

Fonódi,

Nagy,

Boratkó

2024

IJMS

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Epigenetic reprogramming in gastrointestinal cancer: biology and translational perspectives

Wang,

Liu,

Zhang

et al. 2024

MedComm

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Gastrointestinal tumors, the second leading cause of human mortality, are characterized by their association with inflammation. Currently, progress in the early diagnosis and effective treatment of gastrointestinal tumors is limited. Recent whole‐genome analyses have underscored their profound heterogeneity and extensive genetic and epigenetic reprogramming. Epigenetic reprogramming pertains to dynamic and hereditable alterations in epigenetic patterns, devoid of concurrent modifications in the underlying DNA sequence. Common epigenetic modifications encompass DNA methylation, histone modifications, noncoding RNA, RNA modifications, and chromatin remodeling. These modifications possess the potential to invoke or suppress a multitude of genes associated with cancer, thereby governing the establishment of chromatin configurations characterized by diverse levels of accessibility. This intricate interplay assumes a pivotal and indispensable role in governing the commencement and advancement of gastrointestinal cancer. This article focuses on the impact of epigenetic reprogramming in the initiation and progression of gastric cancer, esophageal cancer, and colorectal cancer, as well as other uncommon gastrointestinal tumors. We elucidate the epigenetic landscape of gastrointestinal tumors, encompassing DNA methylation, histone modifications, chromatin remodeling, and their interrelationships. Besides, this review summarizes the potential diagnostic, therapeutic, and prognostic targets in epigenetic reprogramming, with the aim of assisting clinical treatment strategies.

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Identification of a DNA-methylome-based signature for prognosis prediction in driver gene-negative lung adenocarcinoma

Shu,

Huang,

Chen

et al. 2024

Cancer Letters

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PTPRO suppresses lymph node metastasis of esophageal carcinoma by dephosphorylating MET

Cited by 6 publications

References 45 publications

Role of Protein Phosphatases in Tumor Angiogenesis: Assessing PP1, PP2A, PP2B and PTPs Activity

Role of Protein Phosphatases in Tumor Angiogenesis: Assessing PP1, PP2A, PP2B and PTPs Activity

Epigenetic reprogramming in gastrointestinal cancer: biology and translational perspectives

Identification of a DNA-methylome-based signature for prognosis prediction in driver gene-negative lung adenocarcinoma

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