Puberty installation and adrenergic response of seminal vesicle from rats exposed prenatally to hydrocortisone

Pereira, Olga; Piffer, Renata C.

doi:10.1016/j.lfs.2005.04.001

Cited by 15 publications

(13 citation statements)

References 32 publications

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“…These data showed an accumulation of secretion in the seminal vesicles of this group by cigarette smoke exposure, probably due to deficiency of seminal vesicle's contraction. This contraction deficiency could be related to low testosterone level in cigarette smoke exposed rats (Garcia et al 2012), since seminal vesicle´s contraction depend on appropriated testosterone level (Pereira et al 2003;Pereira and Piffer 2005). It is well documented that cigarette smoking can decrease weight and some people, mainly adolescents, smoke and try to lose weight with this habit (Johnson et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Semen and reproductive parameters during some abstinence periods after cigarette smoke exposure in male rats

Sankako

Garcia

Piffer

et al. 2013

Braz. arch. biol. technol.

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Section: Discussionmentioning

confidence: 99%

Semen and reproductive parameters during some abstinence periods after cigarette smoke exposure in male rats

Sankako

Garcia

Piffer

et al. 2013

Braz. arch. biol. technol.

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“…Increased plasma testosterone levels have been found in adult male rats exposed to prenatal DEXA (Page et al 2001) or stress (Ward et al 1996). In contrast, reduced plasma testosterone levels have been found in adult male rats prenatally exposed to hydrocortisone (Pereira & Piffer 2005), betamethasone (Piffer et al 2009) or stress (Gerardin et al 1989;Kinsley et al 1992). On the other hand, no changes in plasma testosterone levels were observed in males prenatally exposed to DEXA (Drake et al 2009).…”

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

“…). In contrast, reduced plasma testosterone levels have been found in adult male rats prenatally exposed to hydrocortisone (Pereira & Piffer ), betamethasone (Piffer et al . ) or stress (Gerardin et al .…”

Section: Discussionmentioning

confidence: 99%

“…This treatment also reduced the weight of the testis and prostate in adult life. Reduced testicular weight has been observed in adult male rats exposed to prenatal betamethasone or hydrocortisone (Pereira & Piffer 2005;Piffer et al 2009). On the other hand, no change in testicular or prostate weight was found in a study using a similar dose of DEXA in the same gestational period (Page et al 2001;Drake et al 2009).…”

Section: Discussionmentioning

confidence: 99%

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Foetal exposure to Panax ginseng extract reverts the effects of prenatal dexamethasone in the synthesis of testosterone by Leydig cells of the adult rat

Wanderley

Saraiva

Vieira

et al. 2013

Int J Experimental Path

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The aim of this study was to examine the effect of maternal exposure to Panax ginseng extract (GE) on the prenatal dexamethasone (DEXA)-induced increase in testosterone production by isolated Leydig cells in adult rats. Pregnant rats were treated with (i) GE (200 mg/kg) or vehicle on days 10-21; (ii) DEXA (100 μg/kg) or vehicle on days 14-21; or (iii) a combination of GE plus DEXA at the same doses and with the same regimen. Testosterone production was induced either by the activator of protein kinase A (dbcAMP) or substrates of steroidogenesis [22(R)-hydroxycholesterol (22(R)-OH-C)] and pregnenolone. The capacity of rat Leydig cells exposed to DEXA to synthesize testosterone induced by dbcAMP, 22(R)-OH-C or pregnenolone was increased in comparison with the control group. Combined exposure to DEXA + GE prevented the effect of DEXA on the responsiveness of Leydig cells to all inductors of testosterone synthesis, whereas GE alone did not modify the response to inductors. No modifications in testosterone production were observed under basal conditions. StAR immunoexpression in Leydig cells was not modified by prenatal exposure to DEXA, GE or DEXA + GE. P450scc and glucocorticoid receptor immunoexpression was higher in offspring exposed to DEXA in comparison with the control group. This increased expression was prevented by combined treatment with DEXA + GE. The present findings demonstrate that GE is capable of reversing the effect of DEXA on testosterone synthesis by rat Leydig cells.

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Reproductive disorders in female rats after prenatal exposure to betamethasone

Borges

Pacheco

Guerra

et al. 2017

J of Applied Toxicology

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Betamethasone is the drug of choice for antenatal treatment, promoting fetal lung maturation and decreasing mortality. Previous studies in rats reported male programming and alteration in sperm parameters and sexual behavior following intrauterine betamethasone exposure. The impact on the female reproductive development is not known. In this study, rat female offspring was assessed for sexual development, morphophysiology of the reproductive tract and fertility after maternal exposure to 0.1 mg kg of betamethasone or vehicle on gestational days 12, 13, 18 and 19. The treatment promoted reduction of litter weight on postnatal day 1, morphological masculinization in females, delay in the age of puberty onset, reduction in estrus number, increase in estrous cycle length and increase in luteinizing hormone serum levels and uterus weight. The females from the betamethasone group showed an increase of myometrial uterine area and decrease in endometrial uterine area. These animals also performed less lordosis during the sexual behavior test and showed impaired reproductive performance. The uterus showed higher contraction in the treated group as shown by a pharmacological assay. In conclusion, prenatal betamethasone exposure in rats promoted female masculinization, altered sexual development and reproductive parameters. Copyright © 2017 John Wiley & Sons, Ltd.

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Puberty installation and adrenergic response of seminal vesicle from rats exposed prenatally to hydrocortisone

Cited by 15 publications

References 32 publications

Semen and reproductive parameters during some abstinence periods after cigarette smoke exposure in male rats

Semen and reproductive parameters during some abstinence periods after cigarette smoke exposure in male rats

Foetal exposure to Panax ginseng extract reverts the effects of prenatal dexamethasone in the synthesis of testosterone by Leydig cells of the adult rat

Reproductive disorders in female rats after prenatal exposure to betamethasone

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