Puberty-related influences on brain development

Giedd, Jay N.; Clasen, Liv S.; Lenroot, Rhoshel; Greenstein, Dede; Wallace, Gregory L.; Ordaz, Sarah J.; Molloy, Elizabeth; Blumenthal, Jonathan D.; Tossell, Julia W.; Stayer, Catherine; Samango‐Sprouse, Carole; Shen, Dinggang; Davatzikos, Christos; Merke, Deborah P.; Chrousos, George P.

doi:10.1016/j.mce.2006.04.016

Cited by 267 publications

(197 citation statements)

References 41 publications

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“…In support of this, previous studies have identified gender differences in the neurocognitive impact of marijuana use among humans (Skosnik et al, 2006) and rodents (O'Shea et al, 2004(O'Shea et al, , 2006. Gender differences in the rate and timing of neurodevelopment (Giedd et al, 1999(Giedd et al, , 2006 may also contribute to gender differences in sensitivity to marijuana in adolescence. Although the current study had limited power to detect gender differences, this is an important line for future research.…”

Section: Discussionmentioning

confidence: 54%

Abstinent adolescent marijuana users show altered fMRI response during spatial working memory

Schweinsburg¹,

Nagel²,

Schweinsburg³

et al. 2008

Psychiatry Research: Neuroimaging

172

168

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Marijuana is the most widely used illicit substance among teenagers, yet little is known about the possible neural influence of heavy marijuana use during adolescence. We previously demonstrated an altered functional magnetic resonance imaging (fMRI) activity related to spatial working memory (SWM) among adolescents who were heavy users of after an average of 8 days of abstinence, but the persisting neural effects remain unclear. To characterize the potentially persisting neurocognitive effects of heavy marijuana use in adolescence, we examined fMRI response during SWM among abstinent marijuana-using teens. Participants were 15 MJ teens and 17 demographically similar nonusing controls, ages 16-18. Teens underwent biweekly urine toxicology screens to ensure abstinence for 28 days before fMRI acquisition. Groups performed similarly on the SWM task, but MJ teens demonstrated lower activity in right dorsolateral prefrontal and occipital cortices, yet significantly more activation in right posterior parietal cortex. MJ teens showed abnormalities in brain response during a SWM task compared with controls, even after 1 month of abstinence. The activation pattern among MJ teens may reflect different patterns of utilization of spatial rehearsal and attention strategies, and could indicate altered neurodevelopment or persisting abnormalities associated with heavy marijuana use in adolescence.

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Section: Discussionmentioning

confidence: 54%

Abstinent adolescent marijuana users show altered fMRI response during spatial working memory

Schweinsburg¹,

Nagel²,

Schweinsburg³

et al. 2008

Psychiatry Research: Neuroimaging

172

168

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“…192,193 The impact of puberty upon the development of neural systems of emotion regulation remains to be fully examined. 181,182,194 For example, recent studies indicate puberty-specific changes in brain structure 195 and function, 181,196 particularly in neural regions implicated in emotion processing and regulation (for example, amygdala, hippocampus).…”

Section: Adult Bipolar Disordermentioning

confidence: 99%

A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder

2008

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The ability to regulate emotions is an important part of adaptive functioning in society. Advances in cognitive and affective neuroscience and biological psychiatry have facilitated examination of neural systems that may be important for emotion regulation. In this critical review we first develop a neural model of emotion regulation that includes neural systems implicated in different voluntary and automatic emotion regulatory subprocesses. We then use this model as a theoretical framework to examine functional neural abnormalities in these neural systems that may predispose to the development of a major psychiatric disorder characterized by severe emotion dysregulation, bipolar disorder.

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“…Neurodevelopment continues through adolescence, with ongoing frontal, parietal, and perihippocampal myelination and reductions in cortical synaptic density (Benes et al, 1994;Giedd et al, 2006;Huttenlocher, 1979;Lenroot and Giedd, 2006;Yakovlev and Lecours, 1967). Work in rodents has provided evidence that nicotine is also disruptive to adolescent brain development, resulting in changes in cholinergic neurotransmission, cell membrane complexity, cell signaling, and serotonin receptor density that are similar to but smaller in magnitude than those observed following prenatal nicotine exposure (Abreu-Villaca et al, 2003a, b;Slotkin et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Gender-Specific Effects of Prenatal and Adolescent Exposure to Tobacco Smoke on Auditory and Visual Attention

Jacobsen

Slotkin

Mencl

et al. 2007

Neuropsychopharmacol

136

143

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Prenatal exposure to active maternal tobacco smoking elevates risk of cognitive and auditory processing deficits, and of smoking in offspring. Recent preclinical work has demonstrated a sex-specific pattern of reduction in cortical cholinergic markers following prenatal, adolescent, or combined prenatal and adolescent exposure to nicotine, the primary psychoactive component of tobacco smoke. Given the importance of cortical cholinergic neurotransmission to attentional function, we examined auditory and visual selective and divided attention in 181 male and female adolescent smokers and nonsmokers with and without prenatal exposure to maternal smoking. Groups did not differ in age, educational attainment, symptoms of inattention, or years of parent education. A subset of 63 subjects also underwent functional magnetic resonance imaging while performing an auditory and visual selective and divided attention task. Among females, exposure to tobacco smoke during prenatal or adolescent development was associated with reductions in auditory and visual attention performance accuracy that were greatest in female smokers with prenatal exposure (combined exposure). Among males, combined exposure was associated with marked deficits in auditory attention, suggesting greater vulnerability of neurocircuitry supporting auditory attention to insult stemming from developmental exposure to tobacco smoke in males. Activation of brain regions that support auditory attention was greater in adolescents with prenatal or adolescent exposure to tobacco smoke relative to adolescents with neither prenatal nor adolescent exposure to tobacco smoke. These findings extend earlier preclinical work and suggest that, in humans, prenatal and adolescent exposure to nicotine exerts gender-specific deleterious effects on auditory and visual attention, with concomitant alterations in the efficiency of neurocircuitry supporting auditory attention.

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Puberty-related influences on brain development

Cited by 267 publications

References 41 publications

Abstinent adolescent marijuana users show altered fMRI response during spatial working memory

Abstinent adolescent marijuana users show altered fMRI response during spatial working memory

A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder

Gender-Specific Effects of Prenatal and Adolescent Exposure to Tobacco Smoke on Auditory and Visual Attention

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