Publisher Correction: A functional variant in the OAS1 gene is associated with Sjögren’s syndrome complicated with HBV infection

Liu, Xianjun; Xing, Hongcun; Gao, Wenjing; Yu, Di; Zhao, Yuming; Shi, Xiaorui; Kun, Zhang; Li, Pingya; Yu, Jun; Xu, Wei; Shan, Hongli; Zhang, Kaiyu; Bao, Wanguo; Fu, Xueqi; Yang, Sen; Wang, Shaofeng

doi:10.1038/s41598-018-35438-9

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“…Previous studies have confirmed that OAS1 levels alteration affects antiviral activity, cell growth, cell cycle, apoptosis and immune response ( 7 ). Furthermore, OAS1 SNPs are associated with the occurrence of several diseases, including diabetes ( 10 ), tuberculosis infection ( 30 ), Sjogren’s syndrome ( 31 ), central nervous system (CNS) involvement of enterovirus 71 infection ( 32 ) and multiple sclerosis ( 33 , 34 ). In current study, we found that OAS1 may be involved in multiple biological processes and signaling pathways, such as biological metabolism, DNA replication, proteasome, cytokine receptor interaction, NK cell-mediated cytotoxic effects, graft versus host disease, processing and presentation of antigen and chemokine receptors binding chemokines, and others using GSEA and KEGG annotation analyses.…”

Section: Discussionmentioning

confidence: 99%

Pan-cancer analysis identified OAS1 as a potential prognostic biomarker for multiple tumor types

Jiang,

Deng,

Luo

et al. 2023

Front. Oncol.

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Background2’,5’-oligoadenylate synthetase 1 (OAS1), has been reported as a tumor driver gene in breast carcinoma and pancreatic carcinoma. However, the role of OAS1 in most tumors has not been reported.MethodsThe original data of 35 tumor types were down load from the TCGA (The Cancer Genome Atlas) database and Human Protein Atlas (HPA) database. TIMER2, Kmplot, UALCAN, and TISIDB tools were used to investigate the expression and function of OAS1, and the role of OAS1 in prognosis, diagnostic value, and immune characteristics of pan-cancer. LUAD and PRAD cell lines, A549, H1975, PC-3 and C4-2 were utilized to perform cell function tests.ResultsOAS1 expression was up-regulated in 12 tumor types and down-regulated in 2 tumor types. High OAS1 expression was correlated with poor prognosis in 6 tumor types, while high OAS1 expression was correlated with good prognosis in 2 tumor types. OAS1 was correlated with molecular subtypes in 8 tumor types and immune subtypes in 12 tumor types. OAS1 was positively associated with the expression of numerous immune checkpoint genes and tumor mutational burden (TMB). OAS1 had potential diagnostic value in 15 tumor types. Silence of OAS1 significantly inhibited the cell proliferation ability, and promoted G2/M cell cycle arrest of LUAD and PRAD cells. Meanwhile, silence of OAS1 enhanced cisplatin-induced apoptosis of LUAD and PRAD cells, but weakened cell migration.ConclusionThis pan-cancer study suggests that OAS1can be used as a molecular biomarker for prognosis in pan-cancer and may play an important role in tumor immune response.

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Section: Discussionmentioning

confidence: 99%

Pan-cancer analysis identified OAS1 as a potential prognostic biomarker for multiple tumor types

Jiang,

Deng,

Luo

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

show abstract

Publisher Correction: A functional variant in the OAS1 gene is associated with Sjögren’s syndrome complicated with HBV infection

Abstract: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

Cited by 1 publication

References 0 publications

Pan-cancer analysis identified OAS1 as a potential prognostic biomarker for multiple tumor types

Pan-cancer analysis identified OAS1 as a potential prognostic biomarker for multiple tumor types

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