Publisher Correction: Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments

Fanucchi, Stephanie; Fok, Ezio T.; Dalla, Emiliano; Shibayama, Youtaro; Börner, Kathleen; Chang, Erin Y.; Stoychev, Stoyan; Imakaev, Maxim; Grimm, Dirk; Wang, Kevin C.; Li, Guoliang; Sung, Wing-Kin; Mhlanga, Musa M.

doi:10.1038/s41588-018-0341-3

Cited by 5 publications

(6 citation statements)

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“…During trained immunity, lncRNA-dependent regulation has a significant impact on the epigenetic reprogramming of immune genes (Fanucchi et al, 2021). Several lncRNAs known as immune-gene priming lncRNAs (IPLs) were found by the application of a bioinformatic pipeline that comprised 3D nuclear architecture, lncRNA and enhancer expression data, and the epigenetic status of immune genes at the genome scale (Fanucchi et al, 2019). The WD repeat-containing protein 5 (WDR5)-mixed lineage leukemia protein 1 complex is directed across the chemokine promoters by UMLILO (upstream master lncRNA of the inflammatory chemokine locus), allowing H3K4me3 epigenetic priming, according to careful analysis of a prototypical IPL known as UMLILO (Fanucchi et al, 2019).…”

Section: Lncrnasmentioning

confidence: 99%

“…The Cxcl genes are not trained, and the murine chemokine topologically associating domain is devoid of an IPL. Cxcl genes are trained as a result of the insertion of UMLILO into the chemokine topologically associating domain in murine macrophages (Fanucchi et al, 2019). This offers compelling evidence that the development of trained immunity depends on lncRNA-mediated control.…”

Section: Lncrnasmentioning

confidence: 99%

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Trained immunity in monocyte/macrophage: Novel mechanism of phytochemicals in the treatment of atherosclerotic cardiovascular disease

Wang

Liu²,

Hu³

et al. 2023

Front. Pharmacol.

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Atherosclerosis (AS) is the pathology of atherosclerotic cardiovascular diseases (ASCVD), characterized by persistent chronic inflammation in the vessel wall, in which monocytes/macrophages play a key role. It has been reported that innate immune system cells can assume a persistent proinflammatory state after short stimulation with endogenous atherogenic stimuli. The pathogenesis of AS can be influenced by this persistent hyperactivation of the innate immune system, which is termed trained immunity. Trained immunity has also been implicated as a key pathological mechanism, leading to persistent chronic inflammation in AS. Trained immunity is mediated via epigenetic and metabolic reprogramming and occurs in mature innate immune cells and their bone marrow progenitors. Natural products are promising candidates for novel pharmacological agents that can be used to prevent or treat cardiovascular diseases (CVD). A variety of natural products and agents exhibiting antiatherosclerotic abilities have been reported to potentially interfere with the pharmacological targets of trained immunity. This review describes in as much detail as possible the mechanisms involved in trained immunity and how phytochemicals of this process inhibit AS by affecting trained monocytes/macrophages.

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Section: Lncrnasmentioning

confidence: 99%

Section: Lncrnasmentioning

confidence: 99%

Trained immunity in monocyte/macrophage: Novel mechanism of phytochemicals in the treatment of atherosclerotic cardiovascular disease

Wang

Liu²,

Hu³

et al. 2023

Front. Pharmacol.

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“…As perfectly detailed in the review by Bindu et al (2022), the innate immune reprogramming happening after priming is given via epigenetic and metabolic modifications of trained cells which can lead either to an increase or a decrease in immunity (Boraschi and Italiani, 2018). The mechanisms of this reprogramming are not completely understood yet, though some evidence supports the existence of multiple regulators (Ghisletti et al, 2010;Smale et al, 2014;Fanucchi et al, 2019;Natoli and Ostuni, 2019). In addition, new studies have also suggested changes in DNA methylation patterns and changes in cellular metabolism as a mediator of trained immunity (Donohoe and Bultman, 2012;Cheng et al, 2014;Arts et al, 2016;Verma et al, 2017;Das et al, 2019;Penkov et al, 2019).…”

Section: Innate Immune Memory Definition and Mechanisms Of Innate Imm...mentioning

confidence: 99%

Drosophila melanogaster as a model to study innate immune memory

et al. 2022

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Over the last decades, research regarding innate immune responses has gained increasing importance. A growing body of evidence supports the notion that the innate arm of the immune system could show memory traits. Such traits are thought to be conserved throughout evolution and provide a survival advantage. Several models are available to study these mechanisms. Among them, we find the fruit fly, Drosophila melanogaster. This non-mammalian model has been widely used for innate immune research since it naturally lacks an adaptive response. Here, we aim to review the latest advances in the study of the memory mechanisms of the innate immune response using this animal model.

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“…Currently, accumulated studies have found that non-coding RNAs, including lncRNAs, microRNAs, and circular RNAs (circRNAs), play a regulating role in the development, progression, and prognosis of ARDS (Juan et al, 2018;Fanucchi et al, 2019;Xiao et al, 2020;He et al, 2021). CircRNA is a closed long-chain non-coding RNA with reverse splicing sites.…”

Section: Introductionmentioning

confidence: 99%

CircRNAs in BALF exosomes and plasma as diagnostic biomarkers in patients with acute respiratory distress syndrome caused by severe pneumonia

Sun,

Gao,

Chen

et al. 2023

Front. Cell. Infect. Microbiol.

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BackgroundThe transcriptomic studies targeting circular RNAs (circRNAs) in bronchoalveolar lavage fluid (BALF) exosomes of acute respiratory distress syndrome (ARDS) patients caused by severe pneumonia have rarely been reported. This study aimed to screen and validate abnormally expressed circRNAs in exosomes from BALF of patients with ARDS caused by severe pneumonia and then evaluate the diagnostic values of these circRNAs for ARDS.MethodBALF was collected from four patients with ARDS caused by severe pneumonia and four healthy subjects. CircRNA expression profile was obtained by microarray analysis in BALF exosomes of the discovery cohort. The differentially expressed circRNAs in BALF exosomes were verified by real-time quantitative PCR (RT-qPCR) and underwent competitive endogenous RNA (ceRNA) network construction and functional enrichment analysis.ResultsA total of 629 circRNAs were differentially expressed in BALF exosomes between ARDS patients and healthy subjects. Nine differentially expressed circRNAs were validated by RT-qPCR, and seven were consistent with the results of microarray analysis. CeRNA network analysis was performed for hsa_circRNA_002809, hsa_circRNA_042882, and hsa_circRNA_104034. Functional enrichment analysis showed that the target genes were mainly associated with hypoxia-induced damage, inflammatory response, and the HIF-1 signaling pathway. Hsa_circRNA_042882 and hsa_circRNA_104034 can be regarded as promising diagnostic biomarkers for patients with ARDS caused by severe pneumonia, with remarkable sensitivity and specificity of the area under the curve of 0.8050 and 1 or 0.835 and 0.799, respectively.ConclusionThis study obtained circRNA expression profiles of ARDS patients, and hsa_circRNA_042882 and hsa_circRNA_104034 were regarded as promising diagnostic biomarkers for patients with ARDS caused by severe pneumonia.

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Publisher Correction: Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments

Abstract: In the version of this article originally published, the name of author Serafim Batzoglou was misspelled. The error has been corrected in the HTML and PDF versions of the article.

Cited by 5 publications

References 0 publications

Trained immunity in monocyte/macrophage: Novel mechanism of phytochemicals in the treatment of atherosclerotic cardiovascular disease

Trained immunity in monocyte/macrophage: Novel mechanism of phytochemicals in the treatment of atherosclerotic cardiovascular disease

Drosophila melanogaster as a model to study innate immune memory

CircRNAs in BALF exosomes and plasma as diagnostic biomarkers in patients with acute respiratory distress syndrome caused by severe pneumonia

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