Publishing clinical prActice GuidelinEs (PAGE): Recommendations from editors and reviewers

Yang, Nan; Zhao, Wei; Qi, Wenan; Yao, Chen; Dong, Chongya; Zhai, Zhenguo; Chen, Tong; Liu, Enmei; Li, Guobao; Long, Youlin; Wang, Xinyi; Wang, Zijun; Lei, Ruobing; Zhou, Qi; Chen, Yaolong; Du, Liqing

doi:10.1111/jebm.12479

Cited by 2 publications

(7 citation statements)

References 34 publications

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“…This can be attributed to conflict-of-interest disclosure policies and whether they have been developed or challenges that come with implementation. Transparency is a key aspect in the development of CPGs 27. According to a study on reporting financial conflicts of interest in CPGs, conflict of interest is a threat because adequate literature is documented on the influence of uncontrolled conflict of interest on recommendations 30.…”

Section: Discussionmentioning

confidence: 99%

“…The influence of external activities such as grant funding and ownership of commercial entities have created a bias and affected the process of making recommendations 31. Efforts to balance guideline development groups (GDGs) have improved however included experts in the industry involved in commercial activities which makes it difficult to rule out a conflict of interest 27. Reporting is also an integral part of ensuring transparency, because when a conflict of interest was done but not reported it brings confusion and it will always be assumed that it was not done which may not be the reality 32…”

Section: Discussionmentioning

confidence: 99%

“…Transparency is a key aspect in the development of CPGs. 27 According to a study on reporting financial conflicts of interest in CPGs, conflict of interest is a threat because adequate literature is documented on the influence of uncontrolled conflict of interest on recommendations. 30 The influence of external activities such as grant funding and ownership of commercial entities have created a bias and affected the process of making recommendations.…”

Section: Discussionmentioning

confidence: 99%

“…[24][25][26] According to a study on publishing CPGs, external review plays a critical role in enhancing scientific validity, clarity and feasibility of the guidelines before formal publication. 27 External review is a critical step in enhancing accountability during guideline development. It provides an opportunity for additional inputs and a critical review of the guideline by a specialist before its publication.…”

Section: Discussionmentioning

confidence: 99%

“…31 Efforts to balance guideline development groups (GDGs) have improved however included experts in the industry involved in commercial activities which makes it difficult to rule out a conflict of interest. 27 Reporting is also an integral part of ensuring transparency, because when a conflict of interest was done but not reported it brings confusion and it will always be assumed that it was not done which may not be the reality. 32 Poor applicability threatens the usability of the guidelines at the facility level.…”

Section: Discussionmentioning

confidence: 99%

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Quality assessment of clinical practice guidelines in Kenya using the AGREE II tool: a methodological review

et al. 2023

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ObjectiveTo assess the quality of available and accessible national Clinical Practice Guidelines (CPGs) in Kenya using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool.MethodsWe searched the websites of the Kenyan Ministry of Health, professional associations and contacted experts in relevant organisations. Our scope was guidelines on maternal, neonatal, nutritional disorders, injuries, communicable and non-communicable diseases in Kenya published in the last 5 years until 30 June 2022. Study selection and data extraction were done by three independent reviewers with disagreements resolved via discussion or with a senior reviewer. We conducted a quality assessment using the online English version of AGREE II tool across six domains. Descriptive statistics were analysed using Stata software V.17. The primary outcome was the methodological quality of the included CPGs assessed by the AGREE II tool score.ResultsWe retrieved 95 CPGs and included 24 in the analysis after screening for eligibility. The CPGs scored best in clarity of presentation and least in the rigour of development. In descending order, the appraisal scores (mean and CI) per domain were as follows: Clarity of presentation 82.96% (95% CI 78.35% to 87.57%) with all guidelines scoring above 50%. Scope and purpose 61.75% (95% CI 54.19% to 69.31%) with seven guidelines scoring less than 50%. Stakeholder involvement 45.25% (95% CI 40.01% to 50.49%) with 16 CPGs scoring less than 50%. Applicability domain 19.88% (95% CI 13.32% to 26.43%) with only one CPG scoring above 50%. Editorial independence 6.92% (95% CI 3.47% to 10.37%) with no CPG scoring above 50% and rigour of development 3% (95% CI 0.61% to 5.39%) with no CPG scoring at least 50%.ConclusionOur findings suggest that the quality of CPGs in Kenya is limited mainly by the rigour of development, editorial independence, applicability and stakeholder involvement. Training initiatives on evidence-based methodology among guideline developers are needed to improve the overall quality of CPGs for better patient care.

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Section: Discussionmentioning

confidence: 99%