Puerarin Accelerates Peripheral Nerve Regeneration

Hsiang, Shih Wei; Lee, Han Chung; Tsai, Fuu Jen; Tsai, Chin Chuan; Yao, Chun Hsu; Chen, Yueh Sheng

doi:10.1142/s0192415x11009500

Cited by 15 publications

(9 citation statements)

References 22 publications

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“…Puerarin had an antagonistic action on LPS-activated N9 microglia cells and might be beneficial to the treatment of neurodegenerative disorders (Bai et al, 2010). Puerarin evidently enhanced cultured Schwann cell viability, increased the density of myelinated axons, action potential area, and nerve conductive velocity, and consequently promoted nerve growth, which might be a potential medication for recovery of regenerating peripheral nerves (Hsiang et al, 2011).…”

Section: Other Activitiesmentioning

confidence: 98%

Puerarin: A Review of Pharmacological Effects

Zhou

Zhang

Peng

2013

Phytotherapy Research

531

323

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Puerarin is the major bioactive ingredient isolated from the root of the Pueraria lobata (Willd.) Ohwi, which is well known as Gegen (Chinese name) in traditional Chinese medicine. As the most abundant secondary metabolite, puerarin was isolated from Gegen in the late 1950s. Since then, its pharmacological properties have been extensively investigated. It is available in common foods and is used in alternative medicine. It has been widely used in the treatment of cardiovascular and cerebrovascular diseases, diabetes and diabetic complications, osteonecrosis, Parkinson's disease, Alzheimer's disease, endometriosis, and cancer. The beneficial effects of puerarin on the various medicinal purposes may be due to its wide spectrum of pharmacological properties such as vasodilation, cardioprotection, neuroprotection, antioxidant, anticancer, antiinflammation, alleviating pain, promoting bone formation, inhibiting alcohol intake, and attenuating insulin resistance. However, the direct molecular mechanisms and targets remain unclear. This review provides a comprehensive summary of the pharmacological effects of puerarin.

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Section: Other Activitiesmentioning

confidence: 98%

Puerarin: A Review of Pharmacological Effects

Zhou

Zhang

Peng

2013

Phytotherapy Research

531

323

View full text Add to dashboard Cite

show abstract

“…The PR drug used in previous studies was referenced in this study. 39,40 In the PR-treated groups, PR was administered at a concentration of 50 mg/kg. The dose of PR is based on previous study in the experimental spinal cord injury.…”

Section: Experimental Animalsmentioning

confidence: 99%

Therapeutic Effects of Puerarin Against Anterior Ischemic Optic Neuropathy Through Antiapoptotic and Anti-Inflammatory Actions

Wen²,

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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“…Indeed, besides the anti-hyperglycemia and b-cell protection effects, puerarin was shown to have beneficial actions in ameliorating diabetic complications, including diabetic retinopathy (Teng et al 2009, Hao et al 2012, nephropathy (Shen et al 2009), vascular endothelial cell damage induced by high-glucose , and diabetic osteoporosis . In addition, puerarin is also prescribed for cardiovascular disease in China, and could accelerate peripheral nerve regeneration, and thus might be beneficial to diabetic neuropathy (Hsiang et al 2011) as well. With those pleiotropic benefits on insulin-producing b-cell and its target tissues concomitantly, puerarin may serve as a therapeutic option for diabetes and its complications.…”

Section: Discussionmentioning

confidence: 99%

Puerarin protects pancreatic β-cell survival via PI3K/Akt signaling pathway

Li¹,

Shangguan²,

Liu³

et al. 2014

Journal of Molecular Endocrinology

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Pancreatic b-cell loss because of apoptosis is the major cause of type 1 diabetes (T1D) and late stage T2D. Puerarin possesses anti-diabetic properties; whether it acts directly on pancreatic b-cell is not clear. This study was designed to investigate the effects of puerarin on pancreatic b-cell survival and function. Diabetes was induced in male C57BL/6 mice by a single peritoneal injection of streptozotocin (STZ). Pancreatic b-cell survival and function were assessed in diabetic mice by measuring b-cell apoptosis, b-cell mass, pancreatic insulin content, and glucose tolerance, and in cultured islets and clonial MIN6 b-cells by measuring b-cell viability and apoptosis and glucose-stimulated insulin secretion. We found that pre-treatment with puerarin decreased the incidence of STZ-induced diabetes. Puerarin increased pancreatic b-cell mass via b-cell apoptosis inhibition in diabetic mice, and increased serum insulin, whereas it decreased blood glucose levels and improved glucose tolerance. In cultured islets and MIN6 cells, puerarin protected b-cell from cobalt chloride (CoCl 2 )-induced apoptosis and restored the impaired capacity of glucose-stimulated insulin secretion. Puerarin protection of b-cell survival involved the phosphoinositide 3-kinase (PI3K) /Akt signaling pathway. In conclusion, puerarin protects pancreatic b-cell function and survival via direct effects on b-cells, and its protection of b-cell survival is mediated by the PI3K/Akt pathway. As a safe natural plant extraction, puerarin might serve as a preventive and/or therapeutic approach for diabetes.

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Puerarin Accelerates Peripheral Nerve Regeneration

Cited by 15 publications

References 22 publications

Puerarin: A Review of Pharmacological Effects

Puerarin: A Review of Pharmacological Effects

Therapeutic Effects of Puerarin Against Anterior Ischemic Optic Neuropathy Through Antiapoptotic and Anti-Inflammatory Actions

Puerarin protects pancreatic β-cell survival via PI3K/Akt signaling pathway

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