Puerarin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology

Maciejewska-Turska, Magdalena; Sieniawska, Elwira

doi:10.1007/978-3-030-94753-8_41-1

Cited by 2 publications

(1 citation statement)

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“…Providing the compound 4-coumaroyl-CoA will be achieved by using 4-coumarate-CoAligase (C4CoAL) [17,31,32]. Afterwards, 4-coumaroyl-CoA is converted to isoliquiritigenin by chalcone synthase and chalcone reductase [33][34][35][36][37][38]. Chalcone isomerase (CHI) then catalyzes the formation of liquiritigenin from isoliquiritigenin, which is further catalyzed by 2-hydroxyisoflavanone (IFS) to produce 2,7,4 ′ -trihydroxyisoflavonone [36,37,39].…”

Section: Biosynthesis Of Puerarinmentioning

confidence: 99%

Puerarin—A Promising Flavonoid: Biosynthesis, Extraction Methods, Analytical Techniques, and Biological Effects

Liga,

Paul

2024

IJMS

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Flavonoids, a variety of plant secondary metabolites, are known for their diverse biological activities. Isoflavones are a subgroup of flavonoids that have gained attention for their potential health benefits. Puerarin is one of the bioactive isoflavones found in the Kudzu root and Pueraria genus, which is widely used in alternative Chinese medicine, and has been found to be effective in treating chronic conditions like cardiovascular diseases, liver diseases, gastric diseases, respiratory diseases, diabetes, Alzheimer’s disease, and cancer. Puerarin has been extensively researched and used in both scientific and clinical studies over the past few years. The purpose of this review is to provide an up-to-date exploration of puerarin biosynthesis, the most common extraction methods, analytical techniques, and biological effects, which have the potential to provide a new perspective for medical and pharmaceutical research and development.

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