Puerarin offsets the anticoagulation effect of warfarin in rats by inducing rCyps, upregulating vitamin K epoxide reductase and inhibiting thrombomodulin

Ge, Beikang; Zhang, Zhen; Lam, Tai Ning; Zuo, Zhong

doi:10.1002/bdd.2054

Cited by 9 publications

(4 citation statements)

References 31 publications

(41 reference statements)

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“…Huangqi invigorating qi and enriching the blood vasodilation [20], promoting heart contraction [21], lowering blood pressure [22] Gualouren clearing heat and phlegm, dispelling lumps, moistening the intestines and bowels none Yanhusuo promoting the circulation of blood, invigorating qi, relieving pain protecting against myocardial ischemia injury [23], antiatherosclerosis [24] Chuanxiong invigorating the circulation of blood vasodilation [25], anticoagulant [25], antiatherosclerosis [25], cardioprotective effect [25] Gegen relieving muscular spasm increasing coronary blood flow [26], antiatherosclerosis [27], anticoagulant [28] Danzhuye clearing heat, diuresis none…”

Section: Single Tcm Traditional Use Ihd-related Evidence-based Indica...mentioning

confidence: 99%

Clinical Patterns of Traditional Chinese Medicine for Ischemic Heart Disease Treatment: A Population-Based Cohort Study

et al. 2022

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Background and objectives: Traditional Chinese medicines (TCMs) are widely prescribed to relieve ischemic heart disease (IHD); however, no cohort studies have been conducted on the use of TCMs for patients with IHD. The aim of the study was to analyze TCM prescription patterns for patients with IHD. Materials and Methods: The retrospective population-based study employed a randomly sampled cohort of 4317 subjects who visited TCM clinics. Data were obtained from the National Health Insurance Research Database (NHIRD) of Taiwan for the period covering 2000 to 2017. Data analysis focused on the top ten most commonly prescribed formulae and single TCMs. We also examined the most common two- and three-drug combinations of TCM in single prescriptions. Demographic characteristics included age and sex distributions. Analysis was performed on 22,441 prescriptions. Results: The majority of TCM patients were male (53.6%) and over 50 years of age (65.1%). Zhi-Gan-Cao-Tang (24.76%) was the most frequently prescribed formulae, and Danshen (28.89%) was the most frequently prescribed single TCM for the treatment of IHD. The most common two- and three-drug TCM combinations were Xue-Fu-Zhu-Yu-Tang and Danshen” (7.51%) and “Zhi-Gan-Cao-Tang, Yang-Xin-Tang, and Gua-Lou-Xie-Bai-Ban-Xia-Tang” (2.79%). Conclusions: Our results suggest that most of the frequently prescribed TCMs for IHD were Qi toning agents that deal with cardiovascular disease through the promotion of blood circulation. The widespread use of these drugs warrants large-scale, randomized clinical trials to investigate their effectiveness and safety.

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Section: Single Tcm Traditional Use Ihd-related Evidence-based Indica...mentioning

confidence: 99%

Clinical Patterns of Traditional Chinese Medicine for Ischemic Heart Disease Treatment: A Population-Based Cohort Study

et al. 2022

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“…The CYPs involved in warfarin metabolism include CYP1A1, 2C9, 2C19 and 2B1 in humans. The induction of rCyp2b1, 2c6 and 1a1 after administration of puerarin altered the metabolism of warfarin, intravenously administered puerarin altered the pharmacokinetics of warfarin significantly by shortening t 1/2 , decreasing AUC 0–96h and increasing the clearance of warfarin (Ge et al., 2017).…”

Section: Pharmacokinetics Of Puerarinmentioning

confidence: 99%

Pharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine

Zhang

2019

Drug Delivery

113

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Pueraria lobata (Willd.) Ohwi is a medicinal and edible homologous plant with a long history in China. Puerarin, the main component isolated from the root of Pueraria lobata, possesses a wide range of pharmacological properties. Daidzein and glucuronides are the main metabolites of puerarin and are excreted in the urine and feces. As active substrates of P-gp, multidrug resistance-associated protein and multiple metabolic enzymes, the pharmacokinetics of puerarin can be influenced by different pathological conditions and drug-drug interactions. Due to the poor water-solubility and liposolubility, the applications of puerarin are limited. So far, only puerarin injections and eye drops are on the market. Recent years, researches on improving the bioavailability of puerarin are developing rapidly, various nanotechnologies and preparation technologies including microemulsions and SMEDDS, dendrimers, nanoparticles and nanocrystals have been researched to improve the bioavailability of puerarin. In order to achieve biocompatibility and desired activity, more effective quality evaluations of nanocarriers are required. In this review, we summarize the pharmacokinetics and drug delivery systems of puerarin up to date.

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“…Nilai pH dan pKa dari senyawa menentukan derajat ionisasi analit serta afinitasnya terhadap fase diam dan fase gerak. Pada uji bioanalisis warfarin, banyak fase gerak yang dibuat bersifat asam dengan penambahan buffer [3,8,11,16,20,[23][24][25][26][27][28] atau asam format [1,[5][6][7]10,14,15,17,[21][22][23]26,[29][30][31][32][33][34][35][36]. Hal ini menyebabkan warfarin akan terdapat dalam bentuk tak ter-ion sehingga bersifat non polar dan akan lebih terjerap pada fase diam, sehingga puncak yang dihasilkan dapat memiliki resolusi yang baik.…”

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“…Pada pemisahan warfarin ini, sering digunakan fase gerak asetonitril untuk pelarut bersifat non polar dan air untuk pelarut bersifat polar [1,2,5,7,8,13,18,[29][30][31]33,[37][38][39]. Asetonitril bersifat polar-aprotik, merupakan fase gerak yang umum digunakan dalam sistem HPLC karena berbagai kelebihan yang dimiliki sehingga dapat memenuhi persyaratan pemilihan fase gerak yang baik, diantaranya adalah absorbansi di daerah panjang gelombang sinar UV yang rendah sehingga tidak mengganggu absorbansi sampel, menghasilkan noise yang rendah, dan memberikan bentuk puncak yang baik pada kolom C18.…”

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Review Metode Analisis Warfarin dalam Plasma dengan Berbagai Instrumen

2021

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Warfarin merupakan obat antikoagulan oral yang digunakan untuk menangani penyakit terkait dengan tromboembolisme. Warfarin memiliki indeks terapi yang sempit serta memiliki kecenderungan berinteraksi dengan obat maupun herba sehingga membutuhkan pemantauan yang cermat pada efek farmakologi yang ditimbulkan. Penentuan pemberian dosis serta pengamatan efek dari interaksi warfarin dengan obat atau herba salah satunya dapat diketahui dengan menganalisis konsentrasi warfarin dalam plasma darah. Artikel ini merupakan kajian pustaka yang bertujuan untuk memberikan tinjauan mengenai metode yang digunakan untuk menganalisis konsentrasi warfarin dalam plasma darah serta teknik preparasi sampelnya. Metode yang digunakan dalam review artikel ini menggunakan penelusuran melalui basis data PubMed®. Hasil yang didapatkan bahwa metode yang umum digunakan untuk determinasi warfarin dalam plasma darah yakni high-performance liquid chromatography (HPLC) serta ultra-HPLC dengan detektor ultraviolet (UV), fluoresensi (FLD), diode array (DAD), maupun spektroskopi massa (MS). Metode lainnya yaitu spektrofotometri UV/Vis dan spektrofotometri fluoresensi serta elektroforesis. Dari metode tersebut, metode HPLC dengan detektor spektroskopi massa paling banyak digunakan untuk menganalisis warfarin serta teknik preparasi sampel yang umum digunakan yakni preparasi sampel yang umum digunakan yakni presipitasi protein menggunakan asetonitril sebagai protein presipitan serta penambahan asam untuk meningkatkan nilai recovery warfarin dari plasma darah

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Puerarin offsets the anticoagulation effect of warfarin in rats by inducing rCyps, upregulating vitamin K epoxide reductase and inhibiting thrombomodulin

Abstract: Puerarin increased warfarin metabolism and offset warfarin anticoagulation by inducing rCyps, upregulating VKOR and inhibiting thrombomodulin in rats. The clinical impact of such potential interactions warrants further verification. Copyright © 2016 John Wiley & Sons, Ltd.

Cited by 9 publications

References 31 publications

Clinical Patterns of Traditional Chinese Medicine for Ischemic Heart Disease Treatment: A Population-Based Cohort Study

Clinical Patterns of Traditional Chinese Medicine for Ischemic Heart Disease Treatment: A Population-Based Cohort Study

Pharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine

Review Metode Analisis Warfarin dalam Plasma dengan Berbagai Instrumen

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