Puerarin plays a protective role in chondrocytes by activating Beclin1-dependent autophagy

Li, Guishuang; Rao, Hongming; Xu, Weili

doi:10.1093/bbb/zbaa078

Cited by 8 publications

(6 citation statements)

References 22 publications

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“…Moreover, Wang et al (2018) reported a study in rats with MIA‐induced OA, demonstrated that puerarin alleviates mechanical hyperalgesia in OA rats and prevents cartilage damage. At the level of cell phenotype, puerarin promotes OA mouse chondrocyte autophagy through Beclin1 activation (Li, Rao, & Xu, 2021). An early study also demonstrated that puerarin promotes new bone formation in vivo (Wong & Rabie, 2007).…”

Section: Methodsmentioning

confidence: 99%

Natural anti‐inflammatory products for osteoarthritis: From molecular mechanism to drug delivery systems and clinical trials

Su,

Yu,

Wang

et al. 2023

Phytotherapy Research

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Osteoarthritis (OA) is a degenerative joint disease that affects millions globally. The present nonsteroidal anti‐inflammatory drug treatments have different side effects, leading researchers to focus on natural anti‐inflammatory products (NAIPs). To review the effectiveness and mechanisms of NAIPs in the cellular microenvironment, examining their impact on OA cell phenotype and organelles levels. Additionally, we summarize relevant research on drug delivery systems and clinical randomized controlled trials (RCTs), to promote clinical studies and explore natural product delivery options. English‐language articles were searched on PubMed using the search terms “natural products,” “OA,” and so forth. We categorized search results based on PubChem and excluded “natural products” which are mix of ingredients or compounds without the structure message. Then further review was separately conducted for molecular mechanisms, drug delivery systems, and RCTs later. At present, it cannot be considered that NAIPs can thoroughly prevent or cure OA. Further high‐quality studies on the anti‐inflammatory mechanism and drug delivery systems of NAIPs are needed, to determine the appropriate drug types and regimens for clinical application, and to explore the combined effects of different NAIPs to prevent and treat OA.

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Section: Methodsmentioning

confidence: 99%

Natural anti‐inflammatory products for osteoarthritis: From molecular mechanism to drug delivery systems and clinical trials

Su,

Yu,

Wang

et al. 2023

Phytotherapy Research

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“…The possible mechanism might be associated with upregulation of the NRF2/ARE signaling and downregulation of the NF-κB pathway in C28/I2 chondrocytes ( Lee et al, 2020 ). Puerarin 8 ) also protects chondrocytes by promoting Beclin-1-dependent autophagy and maintaining homeostasis ( Li et al, 2021 ). Curcumin ( 20 ) maintains mitochondrial homeostasis, induces mitophagy, and protects chondrocytes by mediating the AMPK/PINK1/Parkin signaling pathway ( Jin et al, 2022 ).…”

Section: The Interaction Between Oxidative Stress and Oamentioning

confidence: 99%

Natural compounds protect against the pathogenesis of osteoarthritis by mediating the NRF2/ARE signaling

Yang

Liu

et al. 2023

Front. Pharmacol.

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Osteoarthritis (OA), a chronic joint cartilage disease, is characterized by the imbalanced homeostasis between anabolism and catabolism. Oxidative stress contributes to inflammatory responses, extracellular matrix (ECM) degradation, and chondrocyte apoptosis and promotes the pathogenesis of OA. Nuclear factor erythroid 2-related factor 2 (NRF2) is a central regulator of intracellular redox homeostasis. Activation of the NRF2/ARE signaling may effectively suppress oxidative stress, attenuate ECM degradation, and inhibit chondrocyte apoptosis. Increasing evidence suggests that the NRF2/ARE signaling has become a potential target for the therapeutic management of OA. Natural compounds, such as polyphenols and terpenoids, have been explored to protect against OA cartilage degeneration by activating the NRF2/ARE pathway. Specifically, flavonoids may function as NRF2 activators and exhibit chondroprotective activity. In conclusion, natural compounds provide rich resources to explore the therapeutic management of OA by activating NRF2/ARE signaling.

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“…Puerarin has antioxidant, anti-inflammatory, neuroprotective and anti-apoptotic activities, as well as lowering blood sugar and improving microcirculation. In OA, Puerarin has been shown to inhibit ECM degradation, relieve pain, and reduce cartilage destruction ( Peng et al, 2019 ; Chen et al, 2021b ; Li et al, 2021d ). In addition, Puerarin was found to inhibit the production of the inflammatory factors IL-1β, IL-6 and TNF-α and increase type II collagen content in a rat OA model established by anterior cruciate ligament transection ( Ma et al, 2020 ).…”

Section: Potential Drugs and Strategies To Treat Oa By Affecting The ...mentioning

confidence: 99%

PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action

Wang

et al. 2023

Front. Pharmacol.

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Osteoarthritis (OA) is one of the most common degenerative joint diseases, often involving the entire joint. The degeneration of articular cartilage is an important feature of OA, and there is growing evidence that the mitochondrial biogenesis master regulator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) exert a chondroprotective effect. PGC-1α delays the development and progression of OA by affecting mitochondrial biogenesis, oxidative stress, mitophagy and mitochondrial DNA (mtDNA) replication in chondrocytes. In addition, PGC-1α can regulate the metabolic abnormalities of OA chondrocytes and inhibit chondrocyte apoptosis. In this paper, we review the regulatory mechanisms of PGC-1α and its effects on OA chondrocytes, and introduce potential drugs and novel nanohybrid for the treatment of OA which act by affecting the activity of PGC-1α. This information will help to further elucidate the pathogenesis of OA and provide new ideas for the development of therapeutic strategies for OA.

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Puerarin plays a protective role in chondrocytes by activating Beclin1-dependent autophagy

Cited by 8 publications

References 22 publications

Natural anti‐inflammatory products for osteoarthritis: From molecular mechanism to drug delivery systems and clinical trials

Natural anti‐inflammatory products for osteoarthritis: From molecular mechanism to drug delivery systems and clinical trials

Natural compounds protect against the pathogenesis of osteoarthritis by mediating the NRF2/ARE signaling

PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action

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