Pullulan: A novel molecule for biomedical applications

Singh, Ram Sarup; Kaur, Navpreet; Rana, Vikas; Kennedy, John F.

doi:10.1016/j.carbpol.2017.04.089

Cited by 263 publications

(87 citation statements)

References 242 publications

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“…26 Pullulan has a prolonged circulation time in blood due to its electric neutrality and a specific affinity for ASGPR that is often overexpressed by hepatocyte and HCC cells. 18,27 In this study, pullulan was coated on the surfaces of DF nanocores by incubation method to prepare PDF nanoparticles, thus hoping to improve HCCtargeted delivery and/or accumulation of encapsulated cargoes.…”

Section: Results and Discussion Preparation And Characterization Of Pmentioning

confidence: 99%

Pullulan-coated phospholipid and Pluronic F68 complex nanoparticles for carrying IR780 and paclitaxel to treat hepatocellular carcinoma by combining photothermal therapy/photodynamic therapy and chemotherapy

Wang

Zhang

et al. 2017

IJN

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IR780, a near-infrared dye, can also be used as a photosensitizer both for photothermal therapy (PTT) and photodynamic therapy (PDT). In this study, we designed a simple but effective nanoparticle system for carrying IR780 and paclitaxel, thus hoping to combine PTT/PDT and chemotherapy to treat hepatocellular carcinoma (HCC). This nanosystem, named PDF nanoparticles, consisted of phospholipid/Pluronic F68 complex nanocores and pullulan shells. IR780 and paclitaxel were loaded separately into PDF nanoparticles to form PDFI and PDFP nanoparticles, which had regular sphere shapes and relatively small sizes. Upon near-infrared laser irradiation at 808 nm, PDFI nanoparticles showed strong PTT/PDT efficacy both in vitro and in vivo. In MHCC-97H cells, the combined treatment of PDFI nanoparticles/laser irradiation and PDFP nanoparticles exhibited significant synergistic effects on inhibiting cell proliferation and inducing cell apoptosis and cell cycle arrest at G2/M phase. In MHCC-97H tumor-bearing mice, PDFI nanoparticles exhibited excellent HCC-targeting and accumulating capability after intravenous injection. Furthermore, the combined treatment of PDFI nanoparticles/laser irradiation and PDFP nanoparticles also effectively inhibited the tumor growth and the tumor angiogenesis in MHCC-97H tumor-bearing mice. In summary, we put forward a therapeutic strategy for HCC treatment by combining PTT/PDT and chemotherapy.

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Section: Results and Discussion Preparation And Characterization Of Pmentioning

confidence: 99%

Pullulan-coated phospholipid and Pluronic F68 complex nanoparticles for carrying IR780 and paclitaxel to treat hepatocellular carcinoma by combining photothermal therapy/photodynamic therapy and chemotherapy

Wang

Zhang

et al. 2017

IJN

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“…[79] Among the different amphiphilic polymeric materials in which PLGA is involved, this type of copolymers could be a promising option, mainly due to the nontoxic, nonimmunogenic, noncarcinogenic, and naturally nonmutagenic properties of PUL. [80] The copolymer of PLGA and HA, PLGA-HA, is another example of PLGA amphiphilic derivatives. To synthesize this type of copolymers, the aldehyde-terminated HA should be first aminated.…”

Section: Amphiphilic Copolymersmentioning

confidence: 99%

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Martins

Sousa

Araújo

et al. 2017

Adv Healthcare Materials

215

133

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Poly(lactic‐co‐glycolic) acid (PLGA) is one of the most versatile biomedical polymers, already approved by regulatory authorities to be used in human research and clinics. Due to its valuable characteristics, PLGA can be tailored to acquire desirable features for control bioactive payload or scaffold matrix. Moreover, its chemical modification with other polymers or bioconjugation with molecules may render PLGA with functional properties that make it the Holy Grail among the synthetic polymers to be applied in the biomedical field. In this review, the physical–chemical properties of PLGA, its synthesis, degradation, and conjugation with other polymers or molecules are revised in detail, as well as its applications in drug delivery and regeneration fields. A particular focus is given to successful examples of products already on the market or at the late stages of trials, reinforcing the potential of this polymer in the biomedical field.

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“…[31] Polar organic solvent (glycerol), inorganic salt (NaF), organic small molecule (trehalose), protein (bovine serum albumin (BSA)), and polysaccharide (carboxymethyl cellulose (CMC)) are selected to adjust the physical property and the electric performance of the pullulan-based films. The hydrogen bonds were formed during the evaporation of water due to the abundant OH and other functional groups (NH 2 , COOH) ( Figure S1, Supporting Information), [31,[38][39][40] which enabled the formation of pullulan-based films. The hydrogen bonds were formed during the evaporation of water due to the abundant OH and other functional groups (NH 2 , COOH) ( Figure S1, Supporting Information), [31,[38][39][40] which enabled the formation of pullulan-based films.…”

Section: Resultsmentioning

confidence: 99%

“…Generally, the natural biomaterials, prepared into bio-TENGs, are mainly divided into two strategies, including natural proteins and polysaccharides. [31] In the past several decades, pullulan and its derivatives have been widely applied in biomedical, [31] food, [32] pharmaceutical, [33] and petroleum industries [34,35] with the properties of nonmutagenicity, water solubility, editability, [36] nontoxicity, biodegradation, [37] biocompatibility, nonimmunogenicity, and noncarcinogenicity. [31] In the past several decades, pullulan and its derivatives have been widely applied in biomedical, [31] food, [32] pharmaceutical, [33] and petroleum industries [34,35] with the properties of nonmutagenicity, water solubility, editability, [36] nontoxicity, biodegradation, [37] biocompatibility, nonimmunogenicity, and noncarcinogenicity.…”

mentioning

confidence: 99%

A Flexible, Recyclable, and High‐Performance Pullulan‐Based Triboelectric Nanogenerator (TENG)

Ping

et al. 2019

Adv Materials Technologies

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interests on the material engineering, [10,11] structure modification, [12][13][14][15][16] and practical applications. [17][18][19][20][21] However, there are several limitations on biomedical and biowearable applications for TENGs due to the synthetic polymers and nonbiocompatibility of the majority ongoing TENGs. Thus, the natural biomaterialsbased TENGs [22] have immensely attracted the researcher's attentions with the merits of biocompatibility, low cost, and plentiful raw materials. [23][24][25] Wang et al. [24] reported a biodegradable and flexible chitosanbased TENG (chitosan was derived from chitin) and explored the feasibility of laser processing of constituent materials. Jiang et al. [25] developed various fully bioabsorbable natural-materials-based TENGs, which were used as an in vivo voltage source to accelerate the beating rates of dysfunctional cardiomyocyte clusters and improve the consistency of cell contractions. Generally, the natural biomaterials, prepared into bio-TENGs, are mainly divided into two strategies, including natural proteins and polysaccharides. [23] Therein, many other polysaccharides [26][27][28][29] with unique properties are supposed to be researched and optimized for the better electric performance and bioapplications of the bio-TENGs.Pullulan, produced by the yeast-like funguses, [30] is a linear and unbranched micro-organismal polysaccharide with maltotriose repeating units connected by α−(1 → 6) glycosidic bonds. [31] In the past several decades, pullulan and its derivatives have been widely applied in biomedical, [31] food, [32] pharmaceutical, [33] and petroleum industries [34,35] with the properties of nonmutagenicity, water solubility, editability, [36] nontoxicity, biodegradation, [37] biocompatibility, nonimmunogenicity, and noncarcinogenicity. To our knowledge, there is no research about TENGs or wearable devices fabricated with pullulan. Moreover, the excellent properties of pullulan make it possible to design and adjust the composite of the pullulan film, which is more suitable for TENGs and the biowearable devices. Here, we develop a flexible, recyclable, and highperformance pullulan-based TENG to harvest and transform mechanical energy into electric energy. The physical and chemical characterizations and output performance are investigated to optimize the composite and thickness of the pullulan-based TENGs. Then, the feasibility of the pullulan-based TENGs as the wearable device is explored. Finally, we investigate the recycling performance of the pullulan-based TENG, evaluated by the open-circuit voltage of the as-fabricated TENGs.The developments of natural biomaterials-based triboelectric nanogenerators (TENGs) have been emerged with the extensive and promising requirements in biomedical and biowearable fields due to the properties of renewability, cost-effectivity, biocompatibility, and biodegradability. In this work, a flexible, recyclable, and high-performance pullulan-based TENG, fabricated with pullulan and other additives, is developed. Based on the ope...

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Pullulan: A novel molecule for biomedical applications

Cited by 263 publications

References 242 publications

Pullulan-coated phospholipid and Pluronic F68 complex nanoparticles for carrying IR780 and paclitaxel to treat hepatocellular carcinoma by combining photothermal therapy/photodynamic therapy and chemotherapy

Pullulan-coated phospholipid and Pluronic F68 complex nanoparticles for carrying IR780 and paclitaxel to treat hepatocellular carcinoma by combining photothermal therapy/photodynamic therapy and chemotherapy

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

A Flexible, Recyclable, and High‐Performance Pullulan‐Based Triboelectric Nanogenerator (TENG)

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