Pulmonary and meningeal tuberculosis patterns in children at King Abdul-Aziz university hospital in Jeddah, Saudi Arabia: A retrospective study

Fida, Nadia; Farouq, Mohammed; Daghistani, Razan; Alnajar, Abeer; Alamawi, Duha

doi:10.17352/2455-5363.000032

Glob J Infect Dis Clin Res

2020

DOI: 10.17352/2455-5363.000032

|View full text |Cite

Pulmonary and meningeal tuberculosis patterns in children at King Abdul-Aziz university hospital in Jeddah, Saudi Arabia: A retrospective study

Nadia Fida¹,

Mohammed Farouq²,

Razan Daghistani³

et al.

Abstract: Background: Paediatric Tuberculosis (TB) is a signifi cant health problem worldwide, with the World Health Organization (WHO) reporting almost 550,000 children infected with TB yearly. Several factors have affected the TB infection rate in Saudi Arabia, including Hajj and Umrah (Islamic pilgrimages to Mecca), travel, global migration, indigence, inaccessible healthcare services and drug resistance. Objectives: This retrospective study aimed to describe the patterns of pulmonary TB (PTB) and tuberculous meningi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Mycobacterium Tuberculosis Complex in Children Clinical, Radiological Features, Management, Outcome and Susceptibility Pattern

AlHarthi,

Abdullahi,

Bagaber

et al. 2023

International Journal of Pediatrics and Adolescent Medicine

View full text Add to dashboard Cite

Introduction Mycobacterium tuberculosis complex MTC is a major cause of morbidity and mortality globally. The Bacille Calmette-Guérin (BCG) vaccine is most commonly used worldwide. Disseminated BCG disease is one of the vaccine complications that may occur in immunocompromised children. Methods Retrospective study from January 2009 to December 2022. Results We evaluated 66 patients with microbiologically documented M. tuberculosis complex. Immunocompetent were 28 while 38 were immunocompromised. Our data include 46 patients with BCG-related infections. The majority of 26 patients were diagnosed with disseminated BCGiosis, and local BCGitis was found in 20 out of 46. Remaining 20 patients constitute non-BCG-related infections. Chest radiography done in 58 patients and 10.6% had abnormal findings specific for TB. Other image was mainly done for disseminated BCGiosis. The overall acid-fast bacillus AFB smear was positive in 42.4%, polymerase chain reaction (PCR) positive in 75.8% and positive cultures in 97%. Susceptibility of all samples showed high resistance of pyrazinamide 78.2%, and INH 57.8%, while low resistance to RIF and ethambutol. A further subanalysis of the non-BCG group only showed a drop of resistance to 30% for the related group; all strains were pyrazinamide resistant in the same line with the fact that BCG strain is intrinsically resistant to pyrazinamide, all our patients were 100% resistant. We observed four medications showed some advantage over three-drug regimens with respect to mortality in immunocompromised group. The overall outcome in all patients showed 10.6% mortality. Majority were in disseminated BCGiosis, in which 19.2% died. Conclusion: Our center is the main referral hospital in the kingdom with a large number of patients that will help in understanding local data more. Performance of smear and PCR showed variation in relation to different TB diagnoses and sensitivity patterns, giving us insight into different MTB complex strain characteristics that would help in treatment. Sensitivity pattern data will help in keeping updated treatment protocol locally. We recommend managing disseminated BCGiosis with at least four antimycobacterial agents.

show abstract

Mycobacterium Tuberculosis Complex in Children Clinical, Radiological Features, Management, Outcome and Susceptibility Pattern

AlHarthi,

Abdullahi,

Bagaber

et al. 2023

International Journal of Pediatrics and Adolescent Medicine

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Pulmonary and meningeal tuberculosis patterns in children at King Abdul-Aziz university hospital in Jeddah, Saudi Arabia: A retrospective study

Cited by 1 publication

References 28 publications

Mycobacterium Tuberculosis Complex in Children Clinical, Radiological Features, Management, Outcome and Susceptibility Pattern

Mycobacterium Tuberculosis Complex in Children Clinical, Radiological Features, Management, Outcome and Susceptibility Pattern

Contact Info

Product

Resources

About