Pulmonary and thymic lymphoid hyperplasia in primary Sjögren’s syndrome

Kobayashi, Hideo; Ozeki, Yuichi; Aida, Shinsuke

doi:10.1007/s11604-008-0298-8

Cited by 12 publications

(9 citation statements)

References 10 publications

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“…In the present case, both follicular lymphoid hyperplasia in the thymus and prominent atypical lymphoid hyperplasia in multiple lymph nodes were noted. Reactive lymphoid hyperplasia is a benign nodular lesion, histopathologically characterized by marked proliferation of nonneoplastic, polyclonal lymphocytes forming follicles with an active germinal center [ 18 , 19 ]. Follicular hyperplasia or atypical lymphoid hyperplasia is not uncommon in SS [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

T Cell/Histiocyte-Rich Large B Cell Lymphoma of the Thymus: A Diagnostic Pitfall

Reddy

2016

Case Reports in Hematology

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T cell/histiocyte-rich large B cell lymphoma (THRLBCL) is predominantly a nodal disease, with extranodal involvement, such as bone marrow, spleen, and liver. However, primary THRLBCL has never been reported in the thymus in the English literature. Here we report a case of THRLBCL presenting as mediastinal mass and lymphadenopathy. Based on the frozen section diagnosis of “thymoma,” a 12 cm mass was excised. A year later she developed multiple enlarged lymph nodes and pulmonary nodules. Consultant review of the excised mediastinal mass showed scattered large atypical cells that were CD20+ and PAX-5+ and negative for pan-cytokeratin, AE1, and AE3, compatible with THRLBCL and excluding thymoma. The excised lymph nodes were replaced by diffuse infiltrate of small CD3+ lymphocytes and histiocytes with intermingled large CD20+ B lymphoma cells scattered throughout the section. A diagnosis of THRLBCL was made in lymph node, similar to previous thymic lesion. A clonal rearrangement of immunoglobulin heavy chain (IGH) gene was detected, further supporting the diagnosis. This is the first reported case of THRLBCL in thymus. Correct recognition of this entity is critical, because of the difference in therapeutic impact on these patients.

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Section: Discussionmentioning

confidence: 99%

T Cell/Histiocyte-Rich Large B Cell Lymphoma of the Thymus: A Diagnostic Pitfall

Reddy

2016

Case Reports in Hematology

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“…While the case who suffered from thymic hyperplasia combined with primary Sjogren's syndrome have rarely been reported (1,2). In our study, we will report a case of thymic hyperplasia associated with pSS cured by thymectomy.…”

Section: Introductionmentioning

confidence: 88%

Thymic hyperplasia associated with primary Sjogren’s syndrome cured by thymectomy

Cai

et al. 2017

J. Thorac. Dis.

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Thymus hyperplasia associated with Sjogren's syndrome is a rare morbid state. The present study described a 55-year-old woman who presented with a dryness of the oral cavity, and itchy eyes. Chest computed tomography identified a mass, measuring 4×2.5×2.5 cm, located at the anterior mediastinum. The mass was suspected as thymoma, thymic cyst, or teratoma, and resected by thymectomy. The postoperative pathological diagnosis was thymic lymphoid hyperplasia. After 1-year follow-up period, her sicca syndrome has been resolved. The present study records a successful case for thymectomy to treat the patients with thymic hyperplasia associated with primary Sjogren's syndrome (pSS).

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“…opacities were observed in 3 of these 8 cases (38%) (6,9,10). Nodular shadows with air-bronchograms were also seen in 2 cases (25%) (6,10).…”

Section: F I G U R E 2 A) Hi S T O P a T H O L O G I C A L F I N D mentioning

confidence: 94%

“…Nodular shadows with air-bronchograms were also seen in 2 cases (25%) (6,10). A cavitary mass lesion was reported in only 1 patient (11).…”

Section: F I G U R E 2 A) Hi S T O P a T H O L O G I C A L F I N D mentioning

confidence: 96%

A Case of Pulmonary Nodular Lymphoid Hyperplasia with a Resected Cavity, followed by Spontaneous Regression of the Remaining Lesions

et al. 2010

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A 50-year-old man was admitted to our hospital for examination of an abnormal shadow on chest radiography. Computed tomography revealed multiple small nodular shadows in bilateral lung fields, with cavitation in a right S3 lesion that was resected by video-assisted thoracoscopic surgery. Histopathological examination revealed marked proliferation of lymphoid tissue, including many plasma cells that were polyclonal in nature. This case was considered to be pulmonary nodular lymphoid hyperplasia (PNLH). Several residual nodules spontaneously disappeared during the 6 years of follow-up. This was a rare case of PNLH with a resected cavity, followed by spontaneous regression of the remaining lesions.

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Pulmonary and thymic lymphoid hyperplasia in primary Sjögren’s syndrome

Cited by 12 publications

References 10 publications

T Cell/Histiocyte-Rich Large B Cell Lymphoma of the Thymus: A Diagnostic Pitfall

T Cell/Histiocyte-Rich Large B Cell Lymphoma of the Thymus: A Diagnostic Pitfall

Thymic hyperplasia associated with primary Sjogren’s syndrome cured by thymectomy

A Case of Pulmonary Nodular Lymphoid Hyperplasia with a Resected Cavity, followed by Spontaneous Regression of the Remaining Lesions

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