Pulmonary aspergilloma: from classification to management

Harmouchi, H.; Sani, R.; Issoufou, I.; Lakranbi, M.; Ouadnouni, Y.; Smahi, M.

doi:10.1177/0218492319895113

Cited by 15 publications

(19 citation statements)

References 31 publications

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“…It has been reported that the most common symptom associated with PA is hemoptysis in the published series,[ 3 - 5 , 15 ] which occurred in 69.3% of patients in the present study. The rate of hemoptysis decreased by approximately 16% over time, although the difference was not significant.…”

Section: Discussionsupporting

confidence: 52%

“…Similar to the present study, another study indicated that the prevalence of CA significantly decreased over the years (from 80 to 41%). [10] It has been reported that the most common symptom associated with PA is hemoptysis in the published series, [3][4][5]15] which occurred in 69.3% of patients in the present study. The rate of hemoptysis decreased by approximately 16% over time, although the difference was not significant.…”

Section: Discussionmentioning

confidence: 51%

“…The mortality rate ranges from 1 to 4.4% in previous studies. [7][8][9][10][11][12][13][14][15][16][17][18][19][20] The rate of surgical mortality is slightly higher than that reported in the recent literature (5.6%). However, there was a downward trend in the second period compared to that in the first period (4.5% vs. 6.8%).…”

Section: Discussionmentioning

confidence: 99%

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Is there any change in disease presentation and surgical outcomes in patients with pulmonary aspergilloma? An evaluation of the time trend

Pekçolaklar¹,

Çıtak²,

Aksoy³

et al. 2022

Turk Gogus Kalp Dama

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Background: This study aims to investigate the changes in the clinical and radiological presentations of pulmonary aspergilloma in patients undergoing surgery and to evaluate changes in the surgical outcomes over time. Methods: Between January 2000 and January 2020, a total of 88 patients (69 males, 19 females; mean age: 45.4±11.2 years; range, 17 to 70 years) who underwent surgery for pulmonary aspergilloma were retrospectively analyzed. Surgeries performed were divided into two groups based on their chronological order: first period (from 2000 to 2010, n=44) and second period (from 2010 to 2020, n=44). Results: The most frequent underlying disorder was tuberculosis (72.7%), whereas 10 patients did not have any predisposing conditions for pulmonary aspergilloma. Regarding the aspects of radiological imaging and operative findings, 22 patients had simple aspergilloma and 66 patients had complex aspergilloma. Complications and mortality rates were 33.0% and 5.7%, respectively. A statistical downward was observed in the second period compared to that in the first period regarding the rate of patients with tuberculosis history (61.4% vs. 84.1%, p=0.01). There were more patients who did not have any predisposing conditions for pulmonary aspergilloma in the second period and in the simple aspergilloma group (p=0.04 and p<0.001, respectively). Simple aspergilloma was often observed in the second period than that in the first period (31.8% vs. 18.2%). There was no significant difference between the periods regarding the type of surgical resection (p=0.506), whereas in the simple aspergilloma group, more patients underwent wedge resection (p<0.001). There were no significant differences between the periods and radiological groups in terms of complications and mortality. Patients who underwent pneumonectomy had significantly higher rates of complications and mortality (p=0.01 and p=0.03, respectively). Conclusion: Although pulmonary aspergilloma patients who underwent surgery in the last 10 years had a lower history of tuberculosis than those who were operated in the previous 10 years, there was no change in postoperative complications and mortality rates. An increase in simple aspergilloma prevalence may reduce the rate of surgical morbidity.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 51%

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Is there any change in disease presentation and surgical outcomes in patients with pulmonary aspergilloma? An evaluation of the time trend

Pekçolaklar¹,

Çıtak²,

Aksoy³

et al. 2022

Turk Gogus Kalp Dama

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show abstract

“…Aspergilloma is a mass-like fungus ball and represents a non-invasive form of pulmonary aspergillosis. It occurs primarily in patients with underlying structural lung disease, especially in those with previous conditions causing lung cavities such as tuberculosis [2]. Endobronchial aspergilloma is less well described in the literature.…”

Section: Introductionmentioning

confidence: 99%

A Case of Endobronchial Aspergilloma Coexisting With Lung Adenocarcinoma

Hage¹,

Fagel²

2020

Cureus

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Aspergillus species can cause a variety of lung diseases. Endobronchial aspergilloma is a rare clinical entity rarely encountered and often not included in the classification of Aspergillus lung diseases. An 82-year-old woman presented to the outpatient setting with wheezing, shortness of breath, and productive cough. CT of the chest showed the presence of airway enlargement in a finger in glove pattern in the right upper lobe suggestive of allergic bronchopulmonary aspergillosis. Despite adequate treatment the abnormality persisted on repeat imaging. Bronchoscopy with biopsies eventually revealed the presence of hyphal elements suggestive of Aspergillus and poorly differentiated adenocarcinoma. Endobronchial aspergilloma is rare and not included in the classification of Aspergillus lung diseases. It is thought to result from airway colonization by Aspergillus species. Occasionally it can obscure an underlying lung carcinoma and thus delay the diagnosis. Diagnosis is made by pathological examination of biopsy specimens. Optimal treatment is not well established.

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“…They are not transmitted from person to person. Aspergillosis, which is an infection caused by Aspergillus spp., often affects the respiratory system [ 2 ]. Most cases of aspergillosis occur in immunocompromised patients, but its signs and severity vary greatly [ 3 ].…”

Section: Introductionmentioning

confidence: 99%