Pulmonary Blood Pressure and Flow during Atelectasis in the Dog

Glasser, Steven A.; Domino, Karen B.; Lindgren, L.; Parcella, Phyllis; Marshall, Carol Lynn; Marshall, Bryan E.

doi:10.1097/00000542-198303000-00004

Cited by 61 publications

(25 citation statements)

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“…Similar time courses were reported for mild to moderate regional hypoxia when HPV was quantified as diversion of blood flow from the atelectatic left lung of dogs (613) or right-to-left shunt in rabbits with an unventilated N 2 -filled left lung (1969). Mixed venous PO 2 , the main determinant of P s O 2 under these conditions, ranged between 45 and 55 mmHg.…”

Section: Temporal Characteristicssupporting

confidence: 74%

Hypoxic Pulmonary Vasoconstriction

Sylvester

Shimoda

Aaronson

et al. 2012

Physiological Reviews

607

621

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It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last 20 years, it has been clear that the essential sensor, transduction, and effector mechanisms responsible for hypoxic pulmonary vasoconstriction (HPV) reside in the pulmonary arterial smooth muscle cell. The main focus of this review is the cellular and molecular work performed to clarify these intrinsic mechanisms and to determine how they are facilitated and inhibited by the extrinsic influences of other cells. Because the interaction of intrinsic and extrinsic mechanisms is likely to shape expression of HPV in vivo, we relate results obtained in cells to HPV in more intact preparations, such as intact and isolated lungs and isolated pulmonary vessels. Finally, we evaluate evidence regarding the contribution of HPV to the physiological and pathophysiological processes involved in the transition from fetal to neonatal life, pulmonary gas exchange, high-altitude pulmonary edema, and pulmonary hypertension. Although understanding of HPV has advanced significantly, major areas of ignorance and uncertainty await resolution.

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Section: Temporal Characteristicssupporting

confidence: 74%

Hypoxic Pulmonary Vasoconstriction

Sylvester

Shimoda

Aaronson

et al. 2012

Physiological Reviews

607

621

View full text Add to dashboard Cite

show abstract

“…In a canine model of acute atelectasis, in which systemic hypoxemia HPV is evident on this nuclear medicine scan which shows a matched ventilation-perfusion defect, corresponding to a small area of atelectasis in the right lower lobe. was avoided, HPV increased PVR within 15 minutes, reaching a maximal PVR plateau at 1 hour [55].…”

Section: Clinical Relevance Of Hypoxic Pulmonary Vasoconstrictionmentioning

confidence: 99%

An anesthesiologist's guide to hypoxic pulmonary vasoconstriction: implications for managing single-lung anesthesia and atelectasis

Nagendran

Stewart

Hoskinson

et al. 2006

Current Opinion in Anaesthesiology

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“…20% of the response may be related to the venous circuit. HPV may be beneficial in focal hypoxia, such as in atelectasis (Glasser et al 1983), diverting blood from poorly to better ventilated areas of the lung. In such situations, impairment of HPV may consequently lead to insufficient oxygenation.…”

Section: Response To Hypoxiamentioning

confidence: 99%