Pulmonary Coccidioidomycosis

Catanzaro, Antonino; Drutz, David J.

doi:10.1007/978-1-4757-1712-9_10

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…Antibody production may have little effect on the course of the infection, since patients with hypoand agammaglobulinemia handle fungal infections as well as individuals with normal immunoglobulin levels do (44). However, antibody production has been exploited diagnostically since there are very few patients with significant infection who do not demonstrate antibodies against coccidioidin.…”

Section: Diagnosis Of Coccidioides Immitis Infectionmentioning

confidence: 97%

Coccidioidomycosis

Bronnimann

Galgiani

1989

Eur. J. Clin. Microbiol. Infect. Dis.

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Coccidioidomycosis is a largely self-limited fungal respiratory illness. However, the infrequent case of progressive or disseminated disease can be devastating. As international travel to and from endemic areas increases, physicians unfamiliar with the disease may be called upon to recognize and treat serious coccidioidal infections. The major risk factors for dissemination are race and immunosuppression. The most common sites of dissemination are the skin, lymph nodes, bone and meninges. Diagnosis is aided by investigation of the patient's clinical history, delayed-type hypersensitivity skin test reaction, serologic testing, and recovery of organisms from infected tissue or secretions for direct examination and culture. Fungicidal agents are not available, fortunately, fungistatic therapy allows many patients to recover. The availability of both intravenous/intrathecal and oral agents now allows more therapeutic flexibility in the treatment of this disease.

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Section: Diagnosis Of Coccidioides Immitis Infectionmentioning

confidence: 97%

Coccidioidomycosis

Bronnimann

Galgiani

1989

Eur. J. Clin. Microbiol. Infect. Dis.

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“…However, genotyping the causative agent would allow correlation of clinical presentations and outcomes associated with species. Severe disease and death typically occurs in high risk group patients; however, seemingly healthy individuals can succumb as well, without a known host immunologic or pathogen genotypic explanation [ 36 ]. Currently, the range of disease manifestations is suggested to be primarily due to host factors [ 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Differential Thermotolerance Adaptation between Species of Coccidioides

Mead

Hamm

Shaffer

et al. 2020

JoF

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Coccidioidomycosis, or Valley fever, is caused by two species of dimorphic fungi. Based on molecular phylogenetic evidence, the genus Coccidioides contains two reciprocally monophyletic species: C. immitis and C. posadasii. However, phenotypic variation between species has not been deeply investigated. We therefore explored differences in growth rate under various conditions. A collection of 39 C. posadasii and 46 C. immitis isolates, representing the full geographical range of the two species, was screened for mycelial growth rate at 37 °C and 28 °C on solid media. The radial growth rate was measured for 16 days on yeast extract agar. A linear mixed effect model was used to compare the growth rate of C. posadasii and C. immitis at 37 °C and 28 °C, respectively. C. posadasii grew significantly faster at 37 °C, when compared to C. immitis; whereas both species had similar growth rates at 28 °C. These results indicate thermotolerance differs between these two species. As the ecological niche has not been well-described for Coccidioides spp., and disease variability between species has not been shown, the evolutionary pressure underlying the adaptation is unclear. However, this research reveals the first significant phenotypic difference between the two species that directly applies to ecological research.

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Treatment of Coccidioidomycosis

Graybill¹

1988

Annals of the New York Academy of Sciences

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Pulmonary Coccidioidomycosis

Cited by 3 publications

References 17 publications

Coccidioidomycosis

Coccidioidomycosis

Differential Thermotolerance Adaptation between Species of Coccidioides

Treatment of Coccidioidomycosis

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