Pulmonary comorbidities in psoriasis are associated with a high risk of respiratory failure

Abstract

Objectives To identify respiratory comorbidities associated with a high risk of developing respiratory failure in subjects with psoriasis. Methods This was a cross-sectional analysis of data from subjects enrolled in the UK Biobank cohort. All diagnoses were self-reported. The risk of each respiratory comorbidity was compared by logistic regression models adjusting for age, sex, weight, diabetes mellitus, and smoking history; the risk of comorbid respiratory failure for each pulmonary comorbidity was also compared. Results Of the 472,782 Caucasian subjects in the database, 3,285 self-reported a diagnosis of psoriasis. More men and smokers reported psoriasis and were older, had higher weight and body mass index, and lower pulmonary function than non-psoriatic subjects. Those with psoriasis were at significantly higher risk for multiple pulmonary comorbidities compared to those without psoriasis. Furthermore, those with psoriasis had a higher risk for respiratory failure accompanied by asthma and airflow limitation than non-psoriatic subjects. Conclusions Subjects with psoriasis and pulmonary comorbidities, such as asthma and airflow limitation, are at increased risk for respiratory failure. Common immunopathological links implicating a ‘skin-lung axis’ may underlie psoriasis and pulmonary comorbidities.

Association between psoriasis and asthma: a systematic review and bidirectional meta-analysis

“…By reading the titles and abstracts, according to our inclusion and exclusion criteria, we excluded 3354 irrelevant articles. After reading the remaining 92 articles, we concluded that 16 studies [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] were relevant and included in the analysis.…”

“…The 16 studies were conducted between 2011 and 2023, with a total of 16,657,369 subjects included. Two cohort studies [26,28] and ten cross-sectional studies [25,27,[29][30][31][32][33][34][35][36] looked at the prevalence of asthma in people with psoriasis, while the prevalence of psoriasis in asthma patients was studied in four cohort studies [37][38][39][40]. The main characteristics of the included studies are summarized in Table 1.…”

“…Two cohort studies [26][27][28] and ten cross-sectional studies [25,27,[29][30][31][32][33][34][35][36] explored the risk of asthma in patients with psoriasis. According to the meta-analysis, asthma was associated with an increased incidence of psoriasis (OR = 1.480, 95% CI: 1.282-1.678, I 2 = 95.8%, P < 0.001, Fig.…”