Pulmonary conductance and elastic recoil relationships in asthma and emphysema.

Colebatch, H. J. H.; Finucane, Kevin E.; Smith, Margaret M.

doi:10.1152/jappl.1973.34.2.143

Cited by 112 publications

(71 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…DDA) have long been recognised including: atopic and nonatopic asthma; childhood-onset and adult-onset asthma; reversible and irreversible asthma (as in asthma with COPD); neutrophilic and eosinophilic (and paucigranulocytic) asthma [8]; and steroid-responsive and steroid-nonresponsive asthma indicating an acceptance that bronchial asthma itself is a heterogeneous disease. Similarly, COPD and its synonyms are terms of clinical convenience because the causes and management of the different pathophysiological varieties are similar despite the knowledge that emphysema with primary loss of pulmonary elastic recoil is a different entity from irreversible intrinsic airway narrowing, as demonstrated by COLEBATCH et al [29] .40 yrs ago. The process of phenotypic reclassification needs to be extended, possibly with improved use of better/novel biomarkers [30], to further redefine the processes of airflow obstruction.…”

Section: Resultsmentioning

confidence: 99%

Patterns of airway disease and the clinical diagnosis of asthma in the Busselton population

Musk¹,

Knuiman²,

Hunter³

et al. 2011

Eur Respir J

View full text Add to dashboard Cite

The aim of this study was to examine how objective measures related to lung function cluster in the general population and how the patterns relate to asthma and bronchitis as diagnosed by a doctor (DDA and DDB, respectively).A cross-sectional survey of an age-stratified random general population sample of 1,969 adults from the electoral register of Busselton (Australia) was performed in [2005][2006][2007]. Respiratory symptoms, DDA ever, DDB ever, recent wheezing and smoking history, together with anthropometric measurements, forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), methacholine challenge or bronchodilator response, exhaled nitric oxide (eNO), skin-prick tests to common allergens, and blood eosinophil and neutrophil counts were studied. Cluster analysis (variables sex, age, atopy, FEV1 % predicted, FEV1/FVC, airway hyperresponsiveness, eNO, log eosinphil count, log neutrophil count and body mass index) was used to identify phenotypic patterns.Seven clusters (subjects with DDA and DDB, respectively) were identified: normal males (n5467; 7 and 13%), normal females (n5477; 12 and 18%), obese females (n5250; 16 and 28%), atopic younger adults (n5330; 21 and 17%), atopic adults with high eNO (n5130; 30 and 25%), atopic males with reduced FEV1 (n5103; 33 and 32%) and atopic adults with bronchial hyperreactivity (n5212; 40 and 26%).The clinical diagnosis of asthma (ever) and bronchitis (ever) is not specific for any of the clustering patterns of airway abnormality.

show abstract

Section: Resultsmentioning

confidence: 99%

Patterns of airway disease and the clinical diagnosis of asthma in the Busselton population

Musk¹,

Knuiman²,

Hunter³

et al. 2011

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…The most relevant is the study of COLEBATCH et al [284] which showed that some patients with COPD and ''primary narrowing of airways'' had reduced airway conductance relative to elastic recoil of the lung, suggesting reduced airway distensibility. Whether this equates to a reduced tendency to collapse was not examined.…”

Section: Is Remodelling Only Deleterious or Can It Be Protective?mentioning

confidence: 99%

Clinical relevance of airway remodelling in airway diseases

James¹,

Wenzel²

2007

Eur Respir J

306

214

View full text Add to dashboard Cite

Asthma and chronic obstructive pulmonary disease (COPD) are characterised by airflow obstruction, airway remodelling (measurable structural change) and inflammation. The present review will examine the relationship between airway remodelling in these two conditions with respect to symptoms, abnormal lung function, airway hyperresponsiveness and decline in lung function. The potential for remodelling to be a protective response will also be discussed.Asthma is associated with variable symptoms and changes in lung function and also fixed abnormalities of lung function and an increased rate of decline in lung function with age. There is a relative preservation of the relaxed airway lumen dimensions, prominent thickening of the smooth muscle layer and reduced airway distensibility. The severity of asthma is related to the degree of airway remodelling, which is most marked in cases of fatal asthma.In COPD, symptoms are persistent and predictable but also progressive and are related to fixed abnormalities of lung function. Remodelling is associated with narrowing of the airway lumen and an increased thickness of the airway wall, although not usually to the extent seen in asthma. COPD is most often due to smoking where there is also remodelling of the parenchyma that may contribute to symptoms.

show abstract

“…It was demonstrated several years ago that only the P s l~-G~ slope represents adequately the flow-resistive behavior of the lungs (5,25). In contrast to the static recoil airway conductance (PA,,-G,,) relationship investigated by several authors (16,25), the static recoil lung conductance plot includes lung tissue resistance (2,3).…”

Section: Discussionmentioning

confidence: 99%

“…1). Conversely, if lung conductance is increased by increasing static recoil pressure (as in normal subjects), 0 is high, demonstrating good airway distensibility (5).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Lung Distensibility and Airway Function in Asthmatic Children

Kraemer¹,

Geubelle²

1984

Pediatr Res

View full text Add to dashboard Cite

ABSTRACT. Lung distensibility and airway mechanics were evaluated in 24 asthmatic children and adolescents, ages between 7 and 21 years, by quasi-static pressurevolume curves and by the static recoil-lung conductance relationship. The measurements were obtained by the stepwise inflation technique and the pressure-volume curves were analyzed by a new sigmoid exponential curve-fitting model of the form: VL = Vm + [VM/(l + be-K.P*~)], where

show abstract

Pulmonary conductance and elastic recoil relationships in asthma and emphysema.

Cited by 112 publications

References 0 publications

Patterns of airway disease and the clinical diagnosis of asthma in the Busselton population

Patterns of airway disease and the clinical diagnosis of asthma in the Busselton population

Clinical relevance of airway remodelling in airway diseases

Lung Distensibility and Airway Function in Asthmatic Children

Contact Info

Product

Resources

About