Pulmonary cystic echinococcosis

Santivañez, Saul J.; Garcı́a, Héctor H.

doi:10.1097/mcp.0b013e3283386282

Cited by 100 publications

(146 citation statements)

References 23 publications

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“…CHD mainly involves the liver or lungs, with a liver/lung ratio of 6:1 in asymptomatic subjects and 3:1 in symptomatic subjects (1,11). The increased proportion of lung cases in symptomatic subjects is determined by the higher morbidity of lung cysts, particularly in the presence of complications (rupture or infection) (2,17).…”

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confidence: 99%

“…Serological tools are used only to confirm the diagnosis because of low sensitivity and incomplete specificity (17). Assay performance is mainly dependent on the test format and the nature of the antigen used but also varies according to disease characteristics such as the organs involved, the number of cysts, and the presence of any cyst complications (25,26).…”

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Serological Diagnosis of Lung Cystic Hydatid Disease Using the Synthetic p176 Peptide

Santivañez

Arias

Portocarrero

et al. 2012

Clin Vaccine Immunol

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ABSTRACTCystic hydatid disease (CHD) is a worldwide zoonosis caused by the larval stage of the dog tapewormEchinococcus granulosus. Diagnosis is based on imagenological tools (abdominal ultrasound, chest X-rays, or computed tomography [CT] scan). Serological antibody-detecting assays, using diverse native antigens, have been used as a supportive diagnostic tool, but their sensitivities and specificities differ greatly. The use of synthetic peptides as antigens should provide more reliability and allow better assessment and comparison of test formats and case series. The synthetic peptide p176, corresponding to the N-terminal extreme of the subunit of antigen B (AgB8/1), has shown promising performances for diagnosis of CHD. We evaluated the performance of the synthetic peptide p176 for the diagnosis of pulmonary hydatid disease in an enzyme-linked immunosorbent assay (ELISA) format. Sixty-one serum samples from patients with a diagnosis of pulmonary hydatidosis confirmed by surgery and 128 from healthy volunteers were tested. The overall sensitivity and specificity of the p176 ELISA for lung CHD were 78.69% and 96.88%, respectively. On bivariate analysis, positive serum antibody reactions were associated with the presence of complications and with the number of cysts (single/multiple). Only the presence of persistent complications significantly associated with seropositivity on multivariate logistic regression analysis (odds ratio [OR], 9.58; 95% confidence interval [CI], 2.15 to 42.6;P= 0.003). The p176 ELISA performs well for the diagnosis of lung CHD and adds an easily reproducible diagnostic assay to the existing diagnostic tools.

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confidence: 99%

Serological Diagnosis of Lung Cystic Hydatid Disease Using the Synthetic p176 Peptide

Santivañez

Arias

Portocarrero

et al. 2012

Clin Vaccine Immunol

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“…El objetivo del tratamiento quirúrgico es eliminar de manera segura el parasito y tratar las lesiones pulmonares causadas por el parasito. 1,5,6,7 El tratamiento quirúrgico puede implicar la extirpación del quiste únicamente o la resección del quiste con el parénquima circundante. En la actualidad muchos centros optan por el mantenimiento del parénquima pulmonar tanto como sea posible, recurriendo a la cistostomía, enucleación del quiste intacto o eliminación después de la aspiración con aguja.…”

Section: Discussionunclassified

Pulmonary Hydatid Cyst

Rodríguez¹,

Legal²,

Varela³

et al. 2015

Rev. Cir. Parag

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PULMONARY HYDATID CYST RESUMENLa hidatidosis se define como una zoonosis, de gran extensión mundial, que afecta frecuentemente a adultos jóvenes, endémica de América del Sur, en relación estrecha con animales de granja y estructura sanitaria deficiente. Es una patología ocasionada por Echinococcus Granulosus, con predominio de afectación en hígado y pulmón, siendo menos frecuente en bazo. Se relata el caso de una paciente adulta, que ingresa por síntomas respiratorios de larga evolución. Tras estudios imagenológicos tomográficos se constató colección única tabicada en seno costo frénico izquierdo. Tras sospecha de hidatidosis se realiza esquema de albendazol con posterior intervención quirúrgica. El estudio de anatomía-patológica revela calcificación de tejido compatible por Echinococcus Granulosus. La paciente evoluciona favorablemente y es dada de alta en su quinto día post operatorio.Palabras clave: Equinococosis, Equinococosis pulmonar, Echinococcus Granulosus. ABSTRACTHydatid disease is defined as a zoonosis of worldwide expansion, which often affects young adults, endemic to South America, working closely with farm animals and poor health infrastructure. It is a disease caused by Echinococcus granulosus, predominantly in the liver and lung involvement, being less frequent in the spleen. For an adult patient was admitted for respiratory symptoms longstanding recounted. After tomographic imaging studies partitioned unique collection was found in breast left phrenic cost. After suspicion of hydatid albendazole scheme is performed with subsequent surgery. The study reveals anatomy -pathological tissue calcification compatible with Echinococcus granulosus. The patient is progressing well and is discharged on the fifth postoperative day.

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“…Some symptoms such as weakness, nausea, vomiting and chest deformities are rare (3). Because of immature immunity and increased lung elasticity, larger cysts may be seen in children when compared to adults (3,4). Pulmonary hydatid cyst involves the right lobein 60% of cases, and liver cysts are seen in 20% of cases.…”

Section: Dear Editormentioning

confidence: 99%