Pulmonary embolism complicating the course of COVID-19 –
an underestimated condition?

Pabjan, Paweł; Błoniarczyk, Piotr; Stępień, Piotr; Garbat, Anna; Włosek, Maciej; Zarębska-Michaluk, Dorota

doi:10.5114/ms.2020.99542

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…In December 2019, the first cases of pneumonia caused by the newly identified β-coronavirus were noted in Wuhan, China [1]. The WHO officially announced this disease to be induced by the coronavirus 2019 (COVID-19 -Coronavirus disease 2019).…”

Section: Prefacementioning

confidence: 99%

Otolaryngological procedures during the COVID-19 pandemic

Lichota¹,

Wilczyński²,

Zieliński³

2021

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The purpose of this paper was to present a review of the scientific literature on carrying out typical otolaryngological procedures during the COVID-19 pandemic and periods of increased numbers of SARS-CoV-2 infections. The recommendations on reducing the risk of SARS-CoV-2 infection of ENT (ear, nose, and throat) professionals during typical otolaryngology procedures published by numerous authors are of great importance. The presented recommendations limit the use of unverified advice from the media, in particular, those published on the Internet by the otolaryngological environment not only during the first wave of increase in incidence but also during anticipated recurrent periods of increased numbers of infections caused also by mutated SARS-CoV-2. StreszczenieCelem pracy było przedstawienie przeglądu piśmiennictwa dotyczącego wykonywania typowych procedur otolaryngologicznych w czasie trwania pandemii COVID-19 i w okresach zwiększonej liczby infekcji SARS-CoV-2. Zalecenia dotyczące postępowania z chorymi z infekcją oraz podejrzanymi o infekcję SARS-CoV-2 opublikowane przez wielu autorów mają istotne znaczenie dla zmniejszenia ryzyka zakażenia personelu podczas wykonywania procedur otolaryngologicznych. Przedstawione rekomendacje ograniczają korzystanie z niezweryfikowanych porad publikowanych w mediach, w szczególności w mediach elektronicznych, nie tylko w czasie pierwszej fali wzrostu zachorowań, lecz także w przewidywanych okresach nawrotów zwiększonej liczby zakażeń powodowanych także przez mutacje SARS-CoV-2.

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Section: Prefacementioning

confidence: 99%

Otolaryngological procedures during the COVID-19 pandemic

Lichota¹,

Wilczyński²,

Zieliński³

2021

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The RdRp genotyping of SARS-CoV-2 isolated from patients with different clinical spectrum of COVID-19

Majchrzak,

Madej,

Łysek-Gładysińska

et al. 2024

BMC Infect Dis

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Background The evolution of SARS-CoV-2 has been observed from the very beginning of the fight against COVID-19, some mutations are indicators of potentially dangerous variants of the virus. However, there is no clear association between the genetic variants of SARS-CoV-2 and the severity of COVID-19. We aimed to analyze the genetic variability of RdRp in correlation with different courses of COVID-19. Results The prospective study included 77 samples of SARS-CoV-2 isolated from outpatients (1st degree of severity) and hospitalized patients (2nd, 3rd and 4th degree of severity). The retrospective analyses included 15,898,266 cases of SARS-CoV-2 genome sequences deposited in the GISAID repository. Single-nucleotide variants were identified based on the four sequenced amplified fragments of SARS-CoV-2. The analysis of the results was performed using appropriate statistical methods, with p < 0.05, considered statistically significant. Additionally, logistic regression analysis was performed to predict the strongest determinants of the observed relationships. The number of mutations was positively correlated with the severity of the COVID-19, and older male patients. We detected four mutations that significantly increased the risk of hospitalization of COVID-19 patients (14676C > T, 14697C > T, 15096 T > C, and 15279C > T), while the 15240C > T mutation was common among strains isolated from outpatients. The selected mutations were searched worldwide in the GISAID database, their presence was correlated with the severity of COVID-19. Conclusion Identified mutations have the potential to be used to assess the increased risk of hospitalization in COVID-19 positive patients. Experimental studies and extensive epidemiological data are needed to investigate the association between individual mutations and the severity of COVID-19.

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The Levels of Anti-SARS-CoV-2 Spike Protein IgG Antibodies Before and After the Third Dose of Vaccination Against COVID-19

Łysek-Gładysińska¹,

Starz²,

Borowiec-Sęk³

et al. 2023

JIR

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Purpose The COVID-19 pandemic has been going on for almost three years, and so far, many preventive and therapeutic strategies have been developed. The issue of subsequent booster vaccinations is currently being discussed. We aimed to analyze how the third dose of vaccination against COVID-19 correlates with the dynamics of IgG anti-SARS-CoV-2 spike protein antibody levels in a group of healthy people. Patients and Methods The prospective study included 93 participants before and after a second booster of COVID-19 vaccination, from whom 4 blood samples were collected at intervals. The levels of IgG anti-SARS-CoV-2 in serum were identified using the chemiluminescent immunoassay specific for the receptor-binding domain (RBD) of the S1 protein. The analysis of the results was performed using appropriate statistical methods, considering p <0.05 as a statistically significant value. Results The IgG levels were significantly higher and less diverse after the same follow-up time from the second booster vaccination compared to the first booster. The antibody levels were positively correlated with female, healthcare workers, the elderly and participants with a negative COVID-19 history. Furthermore, the increase in IgG antibodies after the second booster vaccination correlated inversely with the baseline level of antibodies before the vaccination. The latest results showed that antibody levels dropped 1.5-fold after approx. 10 months from the second booster vaccination but still remained at a protective level. Conclusion Booster vaccinations seem to better stimulate immune memory, and in the case of borderline IgG level induces the greatest increase in antibodies. It is worth considering the individual parameters of patients and measuring antibodies before vaccination.

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Pulmonary embolism complicating the course of COVID-19 – an underestimated condition?

Cited by 3 publications

References 15 publications

Otolaryngological procedures during the COVID-19 pandemic

Otolaryngological procedures during the COVID-19 pandemic

The RdRp genotyping of SARS-CoV-2 isolated from patients with different clinical spectrum of COVID-19

The Levels of Anti-SARS-CoV-2 Spike Protein IgG Antibodies Before and After the Third Dose of Vaccination Against COVID-19

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