Pulmonary Embolism Severity Index and Simplified Pulmonary Embolism Severity Index Risk Scores Are Useful to Predict Mortality in Japanese Patients With Pulmonary Embolism

Mizuno, Atsushi; Yamamoto, Takeshi; Tanabe, Yuji; Obayashi, Toru; Takayama, Morimasa; Nagao, Ken

doi:10.1253/circj.cj-14-1433

Cited by 13 publications

(12 citation statements)

References 12 publications

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“…Also, higher sPESI score, high and intermediate-high estimated risk are confirmed as predictors of the 30-day mortality and NACO, which is consistent with the literature data [23][24][25] .…”

Section: Discussionsupporting

confidence: 91%

The significance of C-reactive protein for the prediction of net-adverse clinical outcome in patients with acute pulmonary embolism

et al. 2020

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Background/Aim. Acute pulmonary embolism (APE) may have different clinical manifestations. Also, its outcome can range from complete recovery to early death. Major bleeding (MB) as a due of the therapy also contributes to the overall adverse outcome. So far, it is unknown what the best predictors are for short-term mortality and MB among the several commonly used biomarkers. The aim of this study was to evaluate the significance of Creactive protein (CRP) and other biomarkers for the prediction of adverse clinical outcomes. Methods. This clinical, observational, retrospective-prospective study included 219 consecutive adult patients treated for APE. Results. Among 219 patients, 22 (10%) died within the first month after diagnosis. Twenty seven patients (12.3%) had at least one episode of MB. Composite end-point [netadverse clinical outcome (NACO)] was estimated in 47 (21.5%) of patients. The average values of all biomarkers were higher in the group of patient who died, and differences were statistically significant. Similar results were obtained for composite end-point. In terms of MB, none of biomarkers did not have significance, but CRP had a slight tendency toward significance. Results from univariate logistic regression model showed that troponin was statistically significant predictor of 30-day mortality. However, after adjusting for other variables, in multivariate logistic regression model troponin failed to be significant independent predictor of 30-day mortality. Unlike troponin, CRP and brain natriuretic peptide (BNP) were significant in all models-uni and multivariate (they were independent predictors of 30-day mortality). Conclusion. CRP has a good predictive value for 30-day mortality and NACO, and potential for MB in patients treated for APE.

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Section: Discussionsupporting

confidence: 91%

The significance of C-reactive protein for the prediction of net-adverse clinical outcome in patients with acute pulmonary embolism

et al. 2020

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“…10) These beneficial impacts are particularly important in Japan, which has a relatively long length of hospitalization. 11) In this study, edoxaban was used only in patients with proximal DVT and uncomplicated PE, as in the indications of the global Hokusai-VTE trial. 6) However, edoxaban was also used in patients with distal DVT, after thrombolysis therapy, or concomitantly with an inferior vena cava filter.…”

Section: Discussionmentioning

confidence: 99%

Impact of edoxaban approval for venous thromboembolism on length of hospitalization

Suzuki

Yamamoto

Takagi

et al. 2017

Nihon Kessen Shiketsu Gakkaishi

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Background: The direct anti-Xa agent edoxaban was approved in September 2014 as an alternative to warfarin for treatment of venous thromboembolism (VTE). Methods and Results: The advantages of edoxaban for VTE treatment were assessed by comparing the in-hospital clinical courses of 79 consecutive patients before and after edoxaban approval. Edoxaban was frequently used soon after its approval for VTE. The median length of hospitalization was significantly shorter after than before edoxaban approval (12.0 vs 17.0 days, respectively; p<0.01). Conclusion: Treatment with edoxaban may significantly shorten the length of hospitalization in patients with VTE compared with standard care with warfarin.

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“…These two models successfully can predict short and long term mortality. [17][18][19] PESI is having 11 variables and can be stratified into low, moderate, high and very high risk while sPESI is having 6 variables and grouped as low and high risk. In clinical practice there is no significant difference between PESI and sPESI.…”

Section: Diagnosis Of Acute Pulmonary Embolismmentioning

confidence: 99%

“…In clinical practice there is no significant difference between PESI and sPESI. 17,19) sPESI has shown low efficiency in prediction of mortality in elderly patients. 20) Patients may present some of these signs and symptoms when they develop pulmonary embolism.…”

Section: Diagnosis Of Acute Pulmonary Embolismmentioning

confidence: 99%

Postoperative Acute Pulmonary Embolism Following Pulmonary Resections

Shonyela

Shuang-qiang

Liu

et al. 2015

ATCS

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Postoperative acute pulmonary embolism after pulmonary resections is highly fatal complication. Many literatures have documented cancer to be the highest risk factor for acute pulmonary embolism after pulmonary resections. Early diagnosis of acute pulmonary embolism is highly recommended and computed tomographic pulmonary angiography is the gold standard in diagnosis of acute pulmonary embolism. Anticoagulants and thrombolytic therapy have shown a great success in treatment of acute pulmonary embolism. Surgical therapies (embolectomy and inferior vena cava filter replacement) proved to be lifesaving but many literatures favored medical therapy as the first choice. Prophylaxis pre and post operation is highly recommended, because there were statistical significant results in different studies which supported the use of prophylaxis in prevention of acute pulmonary embolism. Having reviewed satisfactory number of literatures, it is suggested that thoroughly preoperative assessment of patient conditions, determining their risk factors complicating to pulmonary embolism and the use of appropriate prophylaxis measures are the key options to the successful minimization or eradication of acute pulmonary embolism after lung resections.

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Pulmonary Embolism Severity Index and Simplified Pulmonary Embolism Severity Index Risk Scores Are Useful to Predict Mortality in Japanese Patients With Pulmonary Embolism

Cited by 13 publications

References 12 publications

The significance of C-reactive protein for the prediction of net-adverse clinical outcome in patients with acute pulmonary embolism

The significance of C-reactive protein for the prediction of net-adverse clinical outcome in patients with acute pulmonary embolism

Impact of edoxaban approval for venous thromboembolism on length of hospitalization

Postoperative Acute Pulmonary Embolism Following Pulmonary Resections

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