2009
DOI: 10.1093/toxsci/kfp072
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Pulmonary Evaluation of Permissible Exposure Limit of Syntroleum S-8 Synthetic Jet Fuel in Mice

Abstract: No current studies have systematically examined pulmonary health effects associated with Syntroleum S-8 synthetic jet fuel (S-8). In order to gain an understanding about the threshold concentration in which lung injury is observed, C57BL/6 male mice were nose-only exposed to S-8 for 1 h/day for 7 days at average concentrations of 0 (control), 93, 352, and 616 mg/m(3). Evaluation of pulmonary function, airway epithelial barrier integrity, and pathohistology was performed 24 h after the final exposures. Signific… Show more

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Cited by 9 publications
(5 citation statements)
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“…At 352 mg/m 3 , the expiratory lung resistance and lung compliance were reduced, but not in a concentration-dependent manner. At 352 mg/m 3 and above, the vacuole volume density of lamellar bodies was increased and blebs were observed in Clara cells (Wong et al 2009). …”
Section: Studies With Aerosolmentioning
confidence: 98%
“…At 352 mg/m 3 , the expiratory lung resistance and lung compliance were reduced, but not in a concentration-dependent manner. At 352 mg/m 3 and above, the vacuole volume density of lamellar bodies was increased and blebs were observed in Clara cells (Wong et al 2009). …”
Section: Studies With Aerosolmentioning
confidence: 98%
“…Bei 352 mg/m 3 waren der exspiratorische Lungenwiderstand und die Lungencompliance verringert, jedoch ohne Konzentrationsabhängigkeit. Ab 352 mg/m 3 war die Volumendichte der Vakuolen der Lamellarkörper erhöht, und an den Clara-Zellen waren Bläschen zu beobachten (Wong et al 2009).…”
Section: Studien Mit Aerosolunclassified
“…The hydrocarbon composition of non-fossil fuels is different from fossil fuels (Tremblay et al, 2010b). Limited toxicity studies exist for the new alternative fuels (Wong et al, 2009;Wong et al, 2008).…”
Section: Research Articlementioning
confidence: 99%
“…Occupational exposures to jet fuels have been reported to range from 1 to 1000 mg/m 3 (Dossing et al, 1985;Pfaff et al, 1995), while laboratory inhalation toxicity studies in rats have been conducted with jet fuels in the range of 50-4400 mg/m 3 (Baldwin, 2001;Harris et al, 1997b;Hays et al, 1995;Mattie et al, 1991;Wolfe et al, 1996;Wong et al, 2009;Wong et al, 2008). From a regulatory perspective, the Air Force Office of Safety and Health occupational exposure limit is 200 mg/m 3 as a time weighted average, while the short-term exposure limit is 1800 mg/m 3 .…”
Section: Research Articlementioning
confidence: 99%
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