Pulmonary Fibrosis in Generalized Scleroderma: Review of the Literature and Report of Four Further Cases

Lloyd, W. E.; Tonkin, Richard

doi:10.1136/thx.3.4.241

Cited by 20 publications

(3 citation statements)

References 9 publications

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“…21 Heart involvement was carefully documented by Goetz 22 in 1951 in generalised scleroderma. Lloyd and Tonkin 23 enriched the literature on pulmonary fibrosis. Given these obser vations on visceral lesions, a shift in the controversy on scleroderma clustering emerged; if visceral involvement tends to be similar in acrosclerosis and generalised scleroderma, should these conditions be reunited under the same name?…”

Section: Acrosclerosis Scleroderma and Systemic Sclerosis: Nosological Shifts Around A Rare Autoimmune Disordermentioning

confidence: 99%

The nosology of systemic sclerosis: how lessons from the past offer new challenges in reframing an idiopathic rheumatological disorder

Lescoat

Cavalin

Ehrlich

et al. 2019

The Lancet Rheumatology

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Systemic sclerosis is a rare connective tissue disease characterised by a wide range of clinical manifestations. Compared with previous sets of criteria, the 2013 American College of Rheumatology and European League Against Rheumatism (ACR/EULAR) classification of systemic sclerosis encompasses a broader and more relevant spectrum of the condition. Nonetheless, clinical and prognostic heterogeneity persists among patients fulfilling these criteria. The next task in the classification of systemic sclerosis is the development of new subset criteria that can successfully identify subgroups of patients with distinct prognostic or pathophysiological features. In this Viewpoint we describe the history of systemic sclerosis over the past century with the objective of highlighting the effect of previous nosological debates on efforts to understand and manage this disorder. Rather than seeking to present a systematic review of possible subgrouping for systemic sclerosis in relation to prognosis, we aim to clarify how nosological considerations have influenced our understanding of the cause and prognosis of this so-called idiopathic rheumatological disorder and how aetiological, prognostic, and pathophysiological hypotheses have helped to describe clusters within the disease. By reflecting on past nosological debates and endeavours, we identify challenges for the current initiative to develop a new subgrouping of systemic sclerosis.

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Section: Acrosclerosis Scleroderma and Systemic Sclerosis: Nosological Shifts Around A Rare Autoimmune Disordermentioning

confidence: 99%

The nosology of systemic sclerosis: how lessons from the past offer new challenges in reframing an idiopathic rheumatological disorder

Lescoat

Cavalin

Ehrlich

et al. 2019

The Lancet Rheumatology

View full text Add to dashboard Cite

show abstract

“…Pagel, Woolf, and Asher (1949) did not think that the lung pathology was specific. Lloyd and Tonkin (1948) described the clinical sequence in scleroderma lung disease as exertional dyspnoea, dry cough, and reduction in vital capacity. Radiologically this was associated with diffuse fibrosis.…”

Section: Discussionmentioning

confidence: 99%

“…Pulmonary manifestations in diffuse collagen disorders are not uncommon and changes varying from pleural effusions, partial consolidation, widespread reticulation, miliary mottling to chronic fibrosis and sclero-cystic lung disease have been described in the rheumatic diseases (Cheadle, 1888;von Glahn and Pappenheimer, 1926;Masson, Riopelle, and Martin, 1937;Hadfield, 1938;Gouley, 1938;Harkavy, 1941Harkavy, , 1943Rakov and Taylor, 1942;Baggenstoss and Rosenberg, 1943;Gregory and Rich, 1946;Jensen, 1946;Klemperer, 1948;Ellman, 1947;Ellman and Ball, 1948; van Wijk, 1948;and Lees, 1952); in polyarteritis nodosa (Weir, 1939;Elkeles, 1944;Miller and Daley, 1946;and Bergstrand, 1946); in disseminated lupus erythematosus (Tumulty and Harvey, 1949); and in scleroderma (Finlay, 1891;Kraus, 1924;Matsui, 1924;Murphy, Krainin, and Gerson, 1941 ;Linenthal and Talkov, 1941 ;Weiss, Stead, Warren, and Bailey, 1943;Jackman, 1943;Bevans, 1945;Getzowa, 1945;Goetz, 1945;Dostrovsky, 1947;Baehr and Pollack, 1947;Lloyd and Tonkin, 1948;McMichael, 1948 ;Wigley, Edmunds, and Bradley, 1949;Church and Ellis, 1950;…”

mentioning

confidence: 99%