Pulmonary Function Tests in Idiopathic Pulmonary Fibrosis

Bonella, Francesco; Marco, Fabiano Di; Spagnolo, Paolo

doi:10.1007/978-3-319-99975-3_5

Cited by 4 publications

(2 citation statements)

References 47 publications

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“…Pulmonary function tests (PFTs) indicate a restrictive pattern and an altered lung diffusion capacity for carbon monoxide (DLCO) in the vast majority of cases of patients who have recovered after severe forms of COVID-19 ( Table 4 ) [ 60 , 61 ]. In a recently published meta-analysis, which included 380 post-COVID-19 patients, the authors found impaired DLCO and restrictive and obstructive patterns in 39%, 15%, and 7% of subjects [ 61 ].…”

Section: Pulmonary Function Testsmentioning

confidence: 99%

Clinicopathological Outlines of Post-COVID-19 Pulmonary Fibrosis Compared with Idiopathic Pulmonary Fibrosis

et al. 2023

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This review brings together the current knowledge regarding the risk factors and the clinical, radiologic, and histological features of both post-COVID-19 pulmonary fibrosis (PCPF) and idiopathic pulmonary fibrosis (IPF), describing the similarities and the disparities between these two diseases, using numerous databases to identify relevant articles published in English through October 2022. This review would help clinicians, pathologists, and researchers make an accurate diagnosis, which can help identify the group of patients selected for anti-fibrotic therapies and future therapeutic perspectives.

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Section: Pulmonary Function Testsmentioning

confidence: 99%

Clinicopathological Outlines of Post-COVID-19 Pulmonary Fibrosis Compared with Idiopathic Pulmonary Fibrosis

et al. 2023

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“…Spirometry tests, radiologic examinations, and biomarkers have been used in the early detection of air pollution-related diseases. Spirometry tests can accurately predict the progression of the disease but are less sensitive and specific in detecting early pathological changes in respiratory disorders (8)(9). High-resolution computed tomography can detect respiratory disorders in the early stages, but the high costs of this procedure render it impractical for mass-screening purposes (10)(11).…”

Section: Introductionmentioning

confidence: 99%

Exploring the Association Between Air Pollutant Exposure and Krebs von den Lungen-6 (KL 6) Serum Levels in Outdoor and Indoor Workers in Banyumas District, Central Java

Istianah

Roestijawati

Mulyanto

2022

JKL

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Introduction: Indonesia ranks 8th globally in the air pollution index, with poor air quality causing premature deaths from lung ailments such as interstitial lung diseases. Krebs von den Lungen-6 (KL 6) can be used to detect lung disease caused by air pollution. However, the number of studies investigating the link between air pollutant exposure and KL-6 levels is inadequate. The present study explores the association between air pollutant exposure and KL-6 levels in workers in different settings. Methods: This cross-sectional study recruited 70 individuals who were divided into two groups. Dust levels were measured using a particle counter as a proxy for air pollutant levels. KL-6 levels were measured with ELISA. The Spearman correlation test, Mann-Whitney test, and generalized linear model were used in statistical analyses. Results and Discussion: Air pollutant exposure differed significantly between outdoor and indoor settings (p = 0.000). A significant difference was found in KL-6 serum levels between outdoor and indoor workers (p = 0.000). Air pollutant levels were inversely associated with KL-6 serum levels in outdoor (r = -0.557, p < 0.05) and indoor workers (r = -0.360, p < 0.05). Working duration did not significantly correlate with KL-6 serum levels in either group. A tendency of linear association among air pollutant exposure, overall working duration, and KL-6 serum levels was found in the multivariable model. Conclusion: Work settings were associated with varying exposures to air pollutants and KL-6 serum levels. Higher exposure to pollutants may be associated with an increase in KL-6 serum levels.

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A review on importance of bioactive compounds of medicinal plants in treating idiopathic pulmonary fibrosis (special emphasis on isoquinoline alkaloids)

et al. 2021

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Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown cause which disrupts the normal lung architecture and functions by deregulating immune responses and ultimately leads to the death of the individual. A number of factors can lead to its development and currently there is no cure for this disease. Main text There are synthetic drugs available to relieve the symptoms and decelerate its development by targeting pathways involved in the development of IPF, but there had also been various side effects detected by their usage. It is known since decades that medicinal plants and their compounds have been used all over the world in natural medicines to cure various diseases. This review article is focused on the effects of various natural bioactive compounds of 26 plant extracts that show prophylactic and therapeutic properties against the disease and so can be used in treating IPF replacing synthetic drugs and reducing the side effects. Short conclusion This review includes different mechanisms that cause pulmonary fibrosis along with compounds that can induce fibrosis, drugs used for the treatment of pulmonary fibrosis, diagnosis, the biochemical tests used for the experimental study to determine the pathogenesis of disease with a special note on Isoquinoline alkaloids and their role in reducing various factors leading to IPF thus providing promising therapeutic approach.

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Pulmonary Function Tests in Idiopathic Pulmonary Fibrosis

Cited by 4 publications

References 47 publications

Clinicopathological Outlines of Post-COVID-19 Pulmonary Fibrosis Compared with Idiopathic Pulmonary Fibrosis

Clinicopathological Outlines of Post-COVID-19 Pulmonary Fibrosis Compared with Idiopathic Pulmonary Fibrosis

Exploring the Association Between Air Pollutant Exposure and Krebs von den Lungen-6 (KL 6) Serum Levels in Outdoor and Indoor Workers in Banyumas District, Central Java

A review on importance of bioactive compounds of medicinal plants in treating idiopathic pulmonary fibrosis (special emphasis on isoquinoline alkaloids)

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