Pulmonary Functions in Children With Thalassemia Major

Özyörük, Derya; Mısırlıoğlu, Emine Dibek

doi:10.1097/mph.0000000000000425

Cited by 12 publications

(14 citation statements)

References 16 publications

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“…In our study, we found that thalassemic children, when compared to control group, had significantly lower PFT parameters ( P < 0·05) for all except FEV1/FVC% and PEFR%. These results were in accordance with a previous study (Ozyoruk & Misirlioglu, ). However, other studies found all PFT parameters to be significantly lower in thalassemic children, including FEV1/FVC% and PEFR% (Bourli et al, ).…”

Section: Discussionsupporting

confidence: 94%

“…Furthermore, it was one of the restrictive impairment predictors. This is consistent with previous studies (Abu‐Ekteish et al, ; Ozyoruk & Misirlioglu, ). This may be attributed to exaggerated dysynaptic growth beyond the age of 12 years occurring in thalassemia, leading to a disproportionate increase in air spaces than the airway system (Carnelli et al, ).…”

Section: Discussionsupporting

confidence: 94%

“…In the present study, a restrictive ventilatory pattern was present in only 16 (32%) of the thalassemic children. Other published studies reported that restrictive abnormalities were the most frequently reported dysfunction (Azarkeivan et al, 2008;Rahim et al, 2008;Sohn et al, 2011;Ozyoruk & Misirlioglu, 2015). This predominance may be due to the fact that they did not measure lung diffusion capacities (Azarkeivan et al, 2008;Rahim et al, 2008;Ozyoruk & Misirlioglu, 2015) or they targeted adult thalassemic patients in their studies (Sohn et al, 2011).…”

Section: Discussionmentioning

confidence: 98%

“…Thirty-five (70%) thalassemic children had isolated or combined PFT abnormalities. Many studies addressed the pulmonary functions in children with -thalassemia major, reporting percentages of pulmonary dysfunction ranging between 36·1 and 95% (Arora et al, 2001;Abu-Ekteish et al, 2007;Parakh et al, 2007;Rahim et al, 2008;Eidani et al, 2009;Alyasin et al, 2011;Boddu et al, 2015;Ozyoruk & Misirlioglu, 2015). This wide range of percentages may be attributed to the measurement of lung volumes and diffusion capacities, beside spirometry, in some studies and the use of spirometry alone in others.…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary functions in Egyptian children with transfusion‐dependent β‐thalassemia

Hakeem

Mousa

AbdelFattah

et al. 2019

Transfusion Medicine

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SUMMARY Background In β‐thalassemia, there are varying degrees of ineffective haematopoiesis, intermittent haemolysis and iron overload. Excess iron is deposited in organs such as the heart, the liver, the endocrine glands and the lungs. Objectives To evaluate the pulmonary functions in asymptomatic beta thalassemic children on regular transfusion therapy and their relation to iron overload. Methods The study included 50 transfusion‐dependent β‐thalassemic children and 50 apparently healthy children as control. All children had undergone pulmonary function tests (spirometry, lung volumes and diffusion capacities). In addition, test to determine the mean serum ferritin of the last 2 years and pre‐transfusion haemoglobin and chest radiograph and echocardiography were performed for the thalassemic children only. Results A total of 70% of the thalassemic children had diffusion impairment, whereas 34% of them had associated restrictive abnormality. Thalassemic children with serum ferritin >2500 ng mL−1 had significantly lower values of forced vital capacity (FVC), forced expiratory volume at one second (FEV1), peak expiratory flow (PEFR), total lung capacity (TLC) and diffusing capacity of carbon monoxide (DLCO) (P < 0·05). Only diffusion impairment had a significant positive correlation with serum ferritin level. Restrictive impairment had significant positive correlations with age, duration of blood transfusion and serum ferritin level and a significant negative correlation with duration of chelation (P < 0·05). Having a serum ferritin >2500 ng mL−1 was the only predicting factor for diffusion impairment and the strongest predicting factor for restrictive dysfunction. Conclusion Despite being asymptomatic, the majority of thalassemic children in this study suffered from diffusion impairment either alone or in combination with restrictive dysfunction. These pulmonary dysfunctions correlated significantly with body iron stores measured by serum ferritin.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Pulmonary functions in Egyptian children with transfusion‐dependent β‐thalassemia

Hakeem

Mousa

AbdelFattah

et al. 2019

Transfusion Medicine

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“…In our study, FEV1 and FVC values significantly were better in patients with ferritin levels of <2500 ng/dl compared to patients with ferritin levels above 2500 ng/dl. In a study conducted by Ozyörük et al it was reported that there was a significant relation between ferritin levels and FEV1 and FVC values 13 .…”

Section: Discussionmentioning

confidence: 95%

Talasemi major hastalarında asemptomatik solunum fonksiyon bozukluğu

Kazgan

Yağcı-Küpeli

Özhan

2019

Cukurova Medical Journal

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ÖzPurpose: Regular transfusions cause progressive iron deposition in critical organs such as heart, liver and lungs in transfusion-dependent thalassemia (TDT). We aimed to evaluate respiratory dysfunction and factors affecting respiratory dysfunction in patients with TDT. Materials and Methods: Patients with TDT treated at department of Pediatric Hematology/Oncology of Sağlık Bilimleri University, Adana Education and Research Center were evaluated retrospectively.

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Race‐neutral equations for assessment of lung function in children with thalassemia

Moaaz

Badreldin

Chazli

et al. 2023

Pediatric Pulmonology

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The aim of this study was to assess pulmonary dysfunction in children with transfusion‐dependent thalassemia (TDT) using the Global Lung Function Initiative (GLI) 2022 race‐neutral spirometric reference equations and to determine the main predicting factors. The spirometric results of 68 children with TDT were compared to the results of 68 healthy control subjects using both GLI‐2012 reference equations for Caucasians and GLI‐2022 global equations. Associations between the spirometric data and various anthropometric, clinical, and laboratory parameters were analyzed to detect predictors of pulmonary dysfunction in this group of patients. Children with TDT showed significantly lower values of FVC and FEV1 with a predominance of the restrictive pattern (23.53%). Thalassemic children with the restrictive pattern were significantly older, had a longer duration of regular blood transfusion, lower height, weight, and BMI z‐scores, higher average serum ferritin, and higher frequency of having a serum ferritin level >2500 ng/mL. The strongest predictor for having a restrictive spirometric pattern was high serum ferritin. Our analysis shows that the transition from GLI‐2012 spirometric reference equations for Caucasians to the GLI‐2022 global equations has led to a reduction in the prevalence rate of restrictive pulmonary dysfunction in children with TDT, which should not affect the patient outcome in the long term. Asymptomatic children with TDT exhibited a restrictive spirometric pattern in a significant proportion. The most important predictor was high serum ferritin. We encourage the inclusion of pulmonary function testing in the routine monitoring of patients with TDT, especially in older patients and those with iron overload.

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Pulmonary Functions in Children With Thalassemia Major

Cited by 12 publications

References 16 publications

Pulmonary functions in Egyptian children with transfusion‐dependent β‐thalassemia

Pulmonary functions in Egyptian children with transfusion‐dependent β‐thalassemia

Talasemi major hastalarında asemptomatik solunum fonksiyon bozukluğu

Race‐neutral equations for assessment of lung function in children with thalassemia

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