“…Despite recent advances, the IE outcome remains poor. More research is needed, particularly in uncommon subgroups such as children [14,15], pulmonary IE [16], multivalvular IE [17], patients with solid organ transplantation [18,19], bicuspid aortic valves [20], and those treated with oral therapy [21]. In addition, better prognostic markers [22,23], more specific imaging techniques [24], and improved surgical scores [25] that aid in clinical decision-making are required.…”