Pulmonary Issues in Patients with Chronic Neuromuscular Disease

Benditt, Joshua O.; Boitano, Louis J

doi:10.1164/rccm.201210-1804ci

Cited by 124 publications

(101 citation statements)

References 85 publications

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“…It decreases the incidence of shallow breathing, decreasing the carbon dioxide and increasing the oxygen in the blood. [13,14,16]. Even though there are studies which shows its effectiveness, there are many other studies which shows that NIV cannot be used for patients who have acute neuromuscular disorders like Guillain-Barre syndrome (GBS).…”

Section: Review Of Literaturementioning

confidence: 99%

The effectiveness of non-invasive ventilation in neuromuscular patients in KAMC

et al. 2018

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Introduction:The impact of non-invasive ventilation on neuromuscular disease (NMD) has become evident over the past two decades due to frequent use of this technique. It allows some patients with non-progressive pathology to almost live a normal life. The purpose of this study is to indicate the impact of NIV and its results in NMD patients. Objectives: The primary objectives for the study were to find the incidence and outcome of NMD patient on NIV, to determine whether NIV can avoid intubation and Mechanical ventilation and to compare vital signs and arterial blood gas parameters before and after NIV. Methodology: This retrospective study was conducted during a period from January 2010 to October 2017 in King Abdul-Aziz Medical city (KAMC). The data was collected from Medical Record Department. The collected data got statistically analyzed and results obtained by using SPSS software. A total number of 21 patients admitted in KAMC in adult ICUs, wards, and Emergency room for both males and females with neuromuscular diseases with an age above 18 years old were included. Parameters related to patients and NIV were collected and recorded in an excel sheet and there by SPSS software. Results: A total of 21 patients enrolled in this study. There were 14 males and 7 females. The minimum age 19 years old and the maximum 81 years old with a mean age of 45. Arterial Blood Gas done Pre and Post NIV and compared using paired't' test. The pre and post pH on NIV was significant with a P value (p: 0.029). The pre and post PaCO2 on NIV with a P value (P: 0.034) and oxygenation in pre and post NIV with a P value (P: 0.008) was also significant. Conclusion: In this study, since most of the results indicates poor prognosis, it is difficult to say that NIV improve the quality of life. This can be due to the limitations and bias in the study like the heterogeneity of the diseases and bias can be due to the hospital and its policies.

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Section: Review Of Literaturementioning

confidence: 99%

The effectiveness of non-invasive ventilation in neuromuscular patients in KAMC

et al. 2018

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“…Seule une ventilation mécanique peut être proposée pour aider ou suppléer les muscles respiratoires affaiblis [1]. Par ailleurs, des outils d'aide à la toux peuvent aider à l'expectoration des sécrétions afin d'éviter toute surinfection (kinésithérapie manuelle, CoughAssist ® , air-stacking…) [2][3][4]. Ces différents outils thérapeutiques conjugués à une prise en charge cardiaque adaptée (médicamenteuse, électromécanique [pacemaker]…) permettent, pour certaines pathologies, une survie prolongée avec une qualité de vie jugée comme satisfaisante [5][6][7].…”

Section: Ventilation Par Pipette Buccale (Aspects Cliniques Et Techniunclassified

La prise en charge respiratoire chez le patient neuromusculaire

2016

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Une journée consacrée à la prise en charge respiratoire du patient neuromusculaire a été organisée le 16 septembre 2016 par l’AFM-Téléthon, en collaboration avec la SPLF (Société de Pneumologie de Langue Française) et l’Université de Versailles-Saint-Quentin-en-Yvelines (HandiMedex). Cliniciens, scientifiques et industriels ont échangé sur les conséquences engendrées par une ventilation mécanique au quotidien, en mettant l’accent sur L’existant et Le souhaitable.

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“…23 Pulmonary complications are a well known cause of morbidity and mortality in these patients. 24 Inspiratory muscle weakness decreases the ability to breathe deeply, and expiratory muscle weakness decreases the ability to generate the sufficient intrathoracic pressure during exhalation to cough effectively. While mucus production may be normal, some patients with bulbar muscle involvement may aspirate, leading to airway obstruction and infection.…”

Section: Adult and Pediatric Patients With Neuromuscularmentioning

confidence: 99%

AARC Clinical Practice Guideline: Effectiveness of Nonpharmacologic Airway Clearance Therapies in Hospitalized Patients

et al. 2013

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Airway clearance therapy (ACT) is used in a variety of settings for a variety of ailments. These guidelines were developed from a systematic review with the purpose of determining whether the use of nonpharmacologic ACT improves oxygenation, reduces length of time on the ventilator, reduces stay in the ICU, resolves atelectasis/consolidation, and/or improves respiratory mechanics, versus usual care in 3 populations. For hospitalized, adult and pediatric patients without cystic fibrosis, 1) chest physiotherapy (CPT) is not recommended for the routine treatment of uncomplicated pneumonia; 2) ACT is not recommended for routine use in patients with COPD; 3) ACT may be considered in patients with COPD with symptomatic secretion retention, guided by patient preference, toleration, and effectiveness of therapy; 4) ACT is not recommended if the patient is able to mobilize secretions with cough, but instruction in effective cough technique may be useful. For adult and pediatric patients with neuromuscular disease, respiratory muscle weakness, or impaired cough, 1) cough assist techniques should be used in patients with neuromuscular disease, particularly when peak cough flow is < 270 L/min; CPT, positive expiratory pressure, intrapulmonary percussive ventilation, and high-frequency chest wall compression cannot be recommended, due to insufficient evidence. For postoperative adult and pediatric patients, 1) incentive spirometry is not recommended for routine, prophylactic use in postoperative patients, 2) early mobility and ambulation is recommended to reduce postoperative complications and promote airway clearance, 3) ACT is not recommended for routine postoperative care. The lack of available high-level evidence related to ACT should prompt the design and completion of properly designed studies to determine the appropriate role for these therapies.

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Pulmonary Issues in Patients with Chronic Neuromuscular Disease

Cited by 124 publications

References 85 publications

The effectiveness of non-invasive ventilation in neuromuscular patients in KAMC

The effectiveness of non-invasive ventilation in neuromuscular patients in KAMC

La prise en charge respiratoire chez le patient neuromusculaire

AARC Clinical Practice Guideline: Effectiveness of Nonpharmacologic Airway Clearance Therapies in Hospitalized Patients

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