Pulmonary Metastasis of a Postradiation Breast Epithelioid Angiosarcoma Mimicking Adenocarcinoma

Nicolas, Marlo; Nayar, Ritu; Yeldandi, Anjana V.; Frias, Denise V.S. De

doi:10.1159/000326039

Cited by 15 publications

(11 citation statements)

References 30 publications

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“…EAS is a rare subtype of AS that histologically manifests itself quite differently from the classic AS and may mimic a carcinoma, adenocarcinoma or malignant melanoma. [26][27][28][29][30][31] Electron microscopic examination has revealed that the neoplastic cells possess a prominent cytoskeleton of intermediate filaments, numerous pinocytic vesicles, small intercellular lumina with microvilli on their surfaces and characteristic intracytoplasmic vacuoles. 32 In this case series, none of our patients presented with a lesion that was suggestive of a vascular origin clinically.…”

Section: Discussionmentioning

confidence: 99%

“…There is a male predominance and the prognosis is very poor. This variant serves as a high‐grade, diagnostically challenging neoplasm, as it may be difficult to be distinguished from the more common malignant melanoma or poorly differentiated carcinoma/metastatic carcinoma and adenocarcinoma 26–31 …”

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confidence: 99%

“…This variant serves as a high-grade, diagnostically challenging neoplasm, as it may be difficult to be distinguished from the more common malignant melanoma or poorly differentiated carcinoma/metastatic carcinoma and adenocarcinoma. [26][27][28][29][30][31] Materials and methods In all the patients who are presented below, the biopsy or excision specimens were fixed in 10% buffered formalin and processed routinely. The immunohistochemical testing was performed utilizing a standard streptavidin-biotin complex with peroxidase, done entirely in the BenchMark XT autostainer; Ventana Medical Systems Inc., Tucson, AZ, USA.…”

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confidence: 99%

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Cutaneous epithelioid angiosarcoma: a neoplasm with potential pitfalls in diagnosis

Mobini

2009

J Cutan Pathol

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Angiosarcoma (AS) is a rare neoplasm. Cutaneous AS is the most common form of AS. The epithelioid variant of the disease, however, is a rare entity. This subset can histologically mimic non-vascular neoplasms and impose serious challenges in reaching the correct diagnosis. We present five patients with cutaneous epithelioid angiosarcoma (EAS); in none, the clinical diagnosis included a vascular lesion. Three patients had history of breast conservation surgery with/without radiation therapy. Other patients had no previous radiation, and there was no lymphedema in any of the cases. The histopathological examination of the biopsy specimens by hematoxylin and eosin method was not suggestive of a malignant vascular neoplasm initially and the differential diagnoses included carcinoma, malignant melanoma and atypical lymphoid infiltrate. Only after performing immunohistochemical studies that included vascular markers, a definitive diagnosis was possible. Some cases showed unusual histopathological features. Cutaneous EAS is a rare variant of cutaneous AS that can mimic a variety of more common, non-vascular neoplasms, creating a major pitfall in the diagnosis. A careful and thorough histopathological examination and a high index of suspicion, along with appropriate immunohistochemical evaluation, can help reach a correct diagnosis and provide optimal patient care.

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Section: Discussionmentioning

confidence: 99%

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Cutaneous epithelioid angiosarcoma: a neoplasm with potential pitfalls in diagnosis

Mobini

2009

J Cutan Pathol

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“…Pulmonary metastasis is the most likely distant site (3,20); however, there are multiple case reports of irregular patterns of metastasis from mammary AS including metastasis to the cecum presenting with GI bleeding (21), lesions developing in the tonsils (22), the buttock (23), the oropharynx (24), and the heart (25).…”

Section: Presentation and Diagnosismentioning

confidence: 99%

Primary and Secondary Angiosarcoma of the Breast

2016

Contemporary Diagnostic Radiology

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Angiosarcoma is a rare soft tissue tumor of the breast. It occurs in both a primary form without a known precursor, and a secondary form that has been associated to a history of irradiated breast tissue. These forms differ in many ways including median age, precipitating factors, and presentation. Both forms have a malignant behavior and a poor prognosis. The endeavor of this paper is to review what is known about the presentation, diagnostic and therapeutic modalities to date.

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“…Epithelioid angisarcoma (EAS) is a rare subtype of angiosarcoma, and only 18 reported cases exist in the literature describing the cytologic features of this tumor. [6][7][8][9][10][11][12][13][14][15][16] In this letter, such a rare case of EAS of the liver is described.…”

Section: To the Editorsmentioning

confidence: 99%