Pulmonary Nodules: Experimental and Clinical Studies at Low-Dose CT

Diederich, Stefan; Lenzen, H; Windmann, R.; Puskas, Z.; Yelbuz, T. Mesud; Henneken, Stefan; Klaiber, Thomas; Eameri, M.; Roos, N.; Peters, P. E.

doi:10.1148/radiology.213.1.r99oc29289

Cited by 142 publications

(69 citation statements)

References 29 publications

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“…cause of the high intrinsic contrast within the chest and low attenuation of radiation [12][13][14]. However, radiation reduction from lowdose CT could limit its utility for evaluation of mediastinal structures because of inherent narrower range of attenuation densities and noise from photon starvation.…”

Section: Gastrointestinal Imaging Original Researchmentioning

confidence: 99%

Usefulness of Ultralow-Dose (Submillisievert) Chest CT Using Iterative Reconstruction for Initial Evaluation of Sharp Fish Bone Esophageal Foreign Body

Kim

Min

Bista

et al. 2015

American Journal of Roentgenology

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Section: Gastrointestinal Imaging Original Researchmentioning

confidence: 99%

Usefulness of Ultralow-Dose (Submillisievert) Chest CT Using Iterative Reconstruction for Initial Evaluation of Sharp Fish Bone Esophageal Foreign Body

Kim

Min

Bista

et al. 2015

American Journal of Roentgenology

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“…The performance of LDCT was compared to standard-dose CT in a number of studies [13][14][15][16]. They concordantly found that LDCT is equivalent to standarddose CT at least in the detection of lesions larger than 5 mm.…”

Section: Introductionmentioning

confidence: 99%

Detection of pulmonary nodules at multirow-detector CT: effectiveness of double reading to improve sensitivity at standard-dose and low-dose chest CT

et al. 2004

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The purpose of this study was to assess the effectiveness of double reading to increase the sensitivity of lung nodule detection at standard-dose (SDCT) and low-dose multirow-detector CT (LDCT). SDCT (100 mAs effective tube current) and LDCT (20 mAs) of nine patients with pulmonary metastases were obtained within 5 min using four-row detector CT. Softcopy images reconstructed with 5-mm slice thickness were read by three radiologists independently. Images with 1.25-mm slice thickness served as the gold standard. Sensitivity was assessed for single readers and combinations. The effectiveness of double reading was expressed as the increase of sensitivity. Average sensitivity for detection of 390 nodules (size 3.9+/-3.2 mm) for single readers was 0.63 (SDCT) and 0.64 (LDCT). Double reading significantly increased sensitivity to 0.74 and 0.79, respectively. No significant difference between sensitivity at SDCT and LDCT was observed. The percentage of nodules detected by all three readers concordantly was 52% for SDCT and 47% for LDCT. Although double reading increased the detection rate of pulmonary nodules from 63% to 74-79%, a considerable proportion of nodules remained undetected. No difference between sensitivities at LDCT and SDCT for detection of small nodules was observed.

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“…To better characterize tumors and evaluate the mediastinal/hilar structures, intravenous contrast is typically administered for chest CT scans of primary thoracic tumors for initial staging, therapy response assessment, and relapse surveillance. However, chest CT scans performed to detect and follow-up lung metastases from extrathoracic nonlymphomatous tumors can be performed without intravenous contrast (Kuhns and Roubal 1995) at relatively low tube current (Diederich et al 1999) without loss of sensitivity because of the high inherent contrast of aerated lung parenchyma. Use of maximum intensity projection (MIP) images can improve sensitivity for small pulmonary nodules (Coakley et al 1998;Kawel et al 2009).…”

Section: Imagingmentioning

confidence: 99%