Pulmonary Pulse Transit Time: A Novel Echocardiographic Indicator of Hemodynamic and Vascular Alterations in Pulmonary Hypertension and Pulmonary Fibrosis

Abstract

The results of this study suggest that pPTT might be an interesting surrogate marker of pulmonary hemodynamic and vascular alterations in PH and PF. Further studies are warranted to evaluate the possible influence of other variables on pPTT.

Pulmonary arterial hemodynamic assessment by a novel index in systemic lupus erythematosus patients: pulmonary pulse transit time

“…Right heart catheterization is the gold-standard method that exactly establishes a hemodynamic diagnosis of PH ( 9 , 10 ). Ho-wever, it is susceptible to serious complications because of its invasive nature.…”

“…Current guidelines classify PH into 5 categories, namely pulmonary arterial hypertension, PH due to heart diseases, PH due to lung diseases, PH due to a thromboembolic etiology, and PH due to unclear/multifactorial mechanisms. Although these categories have very different pathophysiological pathways, vascular wall changes are considered to be a common patho -logy of PH ( 10 , 13 ). Recently, Wibmer et al ( 10 ) have suggested a new echocardiographic indicator of vascular alterations in PH: “pulmonary pulse transit time” (pPTT).…”

“…Although these categories have very different pathophysiological pathways, vascular wall changes are considered to be a common patho -logy of PH ( 10 , 13 ). Recently, Wibmer et al ( 10 ) have suggested a new echocardiographic indicator of vascular alterations in PH: “pulmonary pulse transit time” (pPTT). They showed that pPTT was shorter in PH patients than in controls and claimed that pPTT is associated with pulmonary hemodynamic and vascular changes.…”

Pulmonary Pulse Wave Transit Time is Associated with Right Ventricular–Pulmonary Artery Coupling in Pulmonary Arterial Hypertension

“…13 Both pulse wave velocity and pulse transit time have been identified as clinically important surrogates for assessing arterial compliance in the systemic circulation. 12 However, the relationship between pulse wave velocity and arterial compliance in the pulmonary circulation has not been examined in detail, probably due to the technical difficulties of measuring pulse wave velocity in the pulmonary circulation.14,15Recently, Wibmer et al 16 showed that pPTT, defined as the delay between onset of ventricular electrical activity (on electrocardiogram) and the arrival of the pulse wave in the pulmonary vein (as determined by Doppler echocardiography of the pulmonary vein), was reduced in 6 patients with World Health Organization (WHO) group 1 pulmonary hypertension and 6 patients with WHO group 3 pulmonary hypertension. Wibmer et al 16 postulated that pPTT was shortened because of decreased pulmonary artery…”

Carotid Arterial Stiffness in Patients with Congenital Heart Disease–Related Pulmonary Hypertension Assessed with Radio Frequency Data Technique

“…PH due to congenital heart disease (CHD) leads to reduced flexibility of the small pulmonary arteries, due to hemodynamic changes in the pulmonary circulation and alterations of the vasoactive profile . Recently, a new echocardiographic parameter, pulmonary pulse transit time, has been proposed that might be an interesting surrogate marker of pulmonary hemodynamic and vascular alterations in pulmonary hypertension . However, it is unknown whether CHD‐related PH affects the elasticity of the systemic arteries, such as the common carotid artery (CCA).…”