Pulmonary sequestration—differences in diagnosis and treatment in a single institution

Lin, Chih-Hung; Chuang, Chun‐Yi; Hsia, Jiun-Yi; Lee, Ming-Ching; Shai, Sen‐Ei; Yang, Shih-Chieh; Hsu, Chung-Ping

doi:10.1016/j.jcma.2013.04.002

Cited by 28 publications

(45 citation statements)

References 21 publications

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“…However, in intralobar sequestration, it is thought that this lesion might be acquired, along with the development of a systemic arterial supply, as a result of a lung infection. [4][5][6] In addition, an association between bronchopulmonary sequestration and abnormal expression of the homeobox gene Hoxb-5 was also described. 4 Diagnosis of intralobar sequestration usually occurs during late adolescence but may remain unrecognized after the age of 20, and it is equally distributed between genders.…”

Section: Discussionmentioning

confidence: 98%

“…1,4,7 It is a relatively rare entity, comprising 0.15-6.45% of all pulmonary malformations. 1,4,6,8 Bronchopulmonary sequestration is diagnosed in the first 2 decades of life in ϳ60% of cases. [4][5][6] Bronchopulmonary sequestration can be classified as intralobar or extralobar sequestration.…”

Section: Discussionmentioning

confidence: 99%

“…1,4,6,8 Bronchopulmonary sequestration is diagnosed in the first 2 decades of life in ϳ60% of cases. [4][5][6] Bronchopulmonary sequestration can be classified as intralobar or extralobar sequestration. Intralobar sequestration is the most common form (ϳ75% of cases) and develops in normal lung tissue without its own visceral pleura.…”

Section: Discussionmentioning

confidence: 99%

“…Extralobar sequestration is a true accessory lung, with its own pleural envelope. [4][5][6] Several theories about bronchopulmonary sequestration etiology have been proposed, [4][5][6]9 and as with any other congenital malformation of the lower respiratory tract, there is an embryological explanation for its origin. This is true for extralobar sequestration, with the widely accepted Pryce's traction theory, where the persistence of systemic arteries causes traction of the lung such that a portion separates from the main lung mass during embryogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6] It usually manifests at younger ages and is rare in adults. Its clinical presentation varies in adulthood.…”

Section: Introductionmentioning

confidence: 99%

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Bronchopulmonary Sequestration Presenting as a Spontaneous Pneumothorax

et al. 2014

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6] It usually manifests at younger ages and is rare in adults. Its clinical presentation varies in adulthood.…”

Section: Introductionmentioning

confidence: 99%

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Bronchopulmonary Sequestration Presenting as a Spontaneous Pneumothorax

et al. 2014

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Extralobar pulmonary sequestration in neonates: The natural course and predictive factors associated with spontaneous regression

et al. 2016

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Retrospective study of prenatal diagnosed pulmonary sequestration

et al. 2013

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Purpose To describe the prenatal findings, treatments and outcomes of fetuses with pulmonary sequestrations (PS), which were retrospectively studied. Methods From May 2010 to January 2013, 292 women were referred to the Guangdong Women and Children Hospital, Guangzhou because obstetric ultrasound had demonstrated fetal lung lesions. In 68 fetuses, the echogenic lung masses were pulmonary sequestrations deriving arterial blood supply from clearly identifiable systemic arteries rather than the pulmonary artery. We examined records of the 68 fetuses and measured the lesions and congenital cystic adenomatoid malformation volume ratio (CVR), provided prenatal counseling and treatment, documented the CVR, location of lesion, gestational age at diagnosis, need for fetal intervention, perinatal clinical course (including the development of hydrops, effusions, and neonatal respiratory distress), gestational age at delivery, postnatal ultrasound and CT, operation treatment, survival and pathology. Results There were 68 PS in our study. All of 56 cases with CVR ≤1.6, survived without prenatal hydrops or postnatal respiratory symptoms. In 12 cases with CVR >1.6, 7 cases (58.3 %, 7/12) had hydrops, 10 cases (83.3 %, 10/12) survived, 2 cases (16.7 %, 2/12) of induced abortion, 8 cases (66 %, 8/12) were postnatal symptomatic. There was statistical significant difference in the incidence rate of hydrops and postnatal respiratory symptoms between the PS with CVR ≤1.6 and that with CVR >1.6. 66 cases postnatal survived, two cases of induced abortion. 64 cases had no prenatal treatment, two cases underwent thoracoamniotic shunt. The mean gestational age at birth was 38 weeks (range 34–40 weeks). 21 asymptomatic cases had no surgery. 45 cases (8 symptomatic and 37 asymptomatic) underwent surgical resections, 43 cases without postoperative complications, two cases of postoperative pneumothorax, no wound infection. Postoperative follow-up showed good growth in all surgery cases. Conclusion PS specific absence of hydrop was a congenital disorder with an excellent prognosis. CVR >1.6 was associated with fetal hydrops and postnatal symptoms. However, absolute CVR value cannot be used to select fetuses for fetal treatment before the development of hydrops. Surgery of PS in neonates or infants presented a good outcome.

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Pulmonary sequestration—differences in diagnosis and treatment in a single institution

Cited by 28 publications

References 21 publications

Bronchopulmonary Sequestration Presenting as a Spontaneous Pneumothorax

Bronchopulmonary Sequestration Presenting as a Spontaneous Pneumothorax

Extralobar pulmonary sequestration in neonates: The natural course and predictive factors associated with spontaneous regression

Retrospective study of prenatal diagnosed pulmonary sequestration

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