Pulmonary ventilation imaged by magnetic resonance: at the doorstep of clinical application

Abstract

Over the past few years, magnetic resonance imaging (MRI) has emerged as an important instrument for functional ventilation imaging. The aim of this review is to summarize established clinical methods and emerging techniques for research and clinical arenas.Before the advent of MRI, chest radiography and computed tomography (CT) dominated morphological lung imaging, while functional ventilation imaging was accomplished with scintigraphy. Initially, MRI was not used for morphological lung imaging often, due to technical and physical limitations. However, recent developments have considerably improved anatomical MRI, as well as advanced new techniques in functional ventilation imaging, such as inhaled contrast aerosols, oxygen, hyperpolarized noble gases (Helium-3, Xenon-129), and fluorinated gases (sulphur-hexafluoride). Straightforward images demonstrating homogeneity of ventilation and determining ventilated lung volumes can be obtained. Furthermore, new image-derived functional parameters are measurable, such as airspace size, regional oxygen partial pressure, and analysis of ventilation distribution and ventilation/perfusion ratios.There are several advantages to using MRI: lack of radiation, high spatial and temporal resolution and a broad range of functional information. The MRI technique applied in patients with chronic obstructive pulmonary disease, emphysema, cystic fibrosis, asthma, and bronchiolitis obliterans, may yield a higher sensitivity in the detection of ventilation defects than ventilation scintigraphy, CT or standard pulmonary function tests.The next step will be to define the threshold between physiological variation and pathological defects. Using complementary strategies, radiologists will have the tools to characterize the impairment of lung function and to improve specificity.

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

“…Gas detection does require special MR instrumentation, due to the exceedingly short T 1 and T 2 relaxation. 19 F MRI of lungs, has, to some extent, been superseded by inert gas approaches exploiting hyperpolarized gases, such as xenon and helium [270][271][272], though this requires expensive preparatory apparatus.…”

Progression of emphysema evaluated by MRI using hyperpolarized 3he (hp 3he) measurements in patients with alpha-1-antitrypsin (a1at) deficiency compared with CT and lung function tests

“…3) and CT-RA-910 increase ( Table 2) indicating emphysema progression, could be explained by suboptimal inspiration level at examination years 1 and 2. Fourth, in severe emphysema, the ADC is probably underestimated, Acta Radiol 2009 (9) because the 3 He gas only enters ventilated areas of the lung. As emphysema progresses, the destruction of the lung will be more pronounced, and areas in the lung without ventilation will arise.…”

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Breast Cancer Gene Therapy: Development of Novel Non-Invasive Magnetic Resonance Assay to Optimize Efficacy

“…19 F MRI of vasculature for a period of hours, and studies have validated lungs, has, to some extent, been superseded by inert gas signal based on traditional radioisotope labeled approaches approaches exploiting hyperpolarized gases, such as xenon and dyes [284,285]. Non-invasive measurements based on and helium [270][271][272], though this requires expensive long term vascular retention allows acute modulation of preparatory apparatus.…”