Pulp capping of dental pulp mechanically exposed to oral microflora: a 1–2 year observation of wound healing in the monkey

Cox, Charles F.; Bergenholtz, Gunnar; Heys, Donald R.; Syed, Salam A.; Fitzgerald, Mark; Heys, Ronald J.

doi:10.1111/j.1600-0714.1985.tb00479.x

Cited by 178 publications

(126 citation statements)

References 19 publications

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“…Calcium hydroxide-based products, which are widely used as liners underlying deep fillings, are also quite sensitive to humidity 36) . Calcium hydroxide material may dissolve and increase the risk of bacterial leakage, caries, and finally pulp complications 37) . In contrast to these materials, CSC as a calcium silicate cement with acceptable strength can get the benefit of the humid environment because of inherent hydrophilic nature.…”

Section: Resultsmentioning

confidence: 99%

Diametral tensile strength of novel fast-setting calcium silicate cement

et al. 2016

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Novel fast-setting calcium silicate cement with fluoride (CSC) has been developed for potential applications in tooth crown. The aim of this study was to test the diametral tensile strength (DTS) of different CSC compositions in humid condition on day1, 28, and 180. We tested 'bond CSC' with 3.5% fluoride and no radiocontrast, 'CSC' with 3.5% fluoride and 10% radiocontrast, 'ultrafast CSC' with 3.5% fluoride and 20% radiocontrast, 'high fluoride CSC' with 15% fluoride and 25% radiocontrast, Biodentine, and MTA. We filled the cements after mixing to cylindrical molds. Specimens were stored in >95% humidity. DTS was measured at each time point. CSC compositions had statistically higher DTS compared to MTA and Biodentine on day1. Bond CSC showed higher DTS versus all cements, except CSC, at all time points. DTS of all cements, except Biodentine, significantly increased in humid condition on day28 and day180 compared to day1.

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Section: Resultsmentioning

confidence: 99%

Diametral tensile strength of novel fast-setting calcium silicate cement

et al. 2016

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“…34,35 At 2 week time point there was inflammatory response and infiltration of PMNs; however, no evidence of collagen formation and absence of differentiated odontoblast. The observed sequence of events were as follows: first there was vascular and inflammatory cell migration and proliferation to control and eliminate the irritating agent, second the repair process occurs with migration and proliferation of mesenchymal pulp cells and deposition of collagen.…”

Section: Dentin Matrix Protein 1 Induces Cytodifferentiation a Almushmentioning

confidence: 99%

Dentin matrix protein 1 induces cytodifferentiation of dental pulp stem cells into odontoblasts

et al. 2005

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Odontoblasts are postmitotic cells that differentiate from the dental papilla. These cells are responsible for producing the calcified dentin matrix. The pulp-odontoblast interphase contains undifferentiated mesenchymal stem cells, which have the ability to cytodifferentiate into odontoblast-like cells in response to specific signaling molecules. Dentin matrix protein 1 (DMP1) is one of the dentin noncollagenous extracellular matrix proteins that has been implicated in regulation of mineralization. In this study, we have examined the potential role of DMP1 in inducing cytodifferentiation of dental pulp stem cells into odontoblast-like cells and formation of reparative dentin in a rat model. Cavities were drilled and pulps exposed in maxillary first molars. Collagen matrix impregnated with recombinant DMP1 was implanted directly in Group 1, while calcium hydroxide, a commonly used pulp-capping agent was implanted in group 2, collagen matrix that was not impregnated with rDMP1 was implanted directly in group 3, which served as control. Each of these three groups was subdivided into two subgroups, A for 2 weeks time duration and B for 4 weeks duration. At the end of the time period the maxillae were excised, tissues were processed for histological and immunohistochemical evaluations. The results showed that DMP1 could act as a morphogen on undifferentiated mesenchymal cells present in the dentin-pulp complex. These differentiated cells had the potential to regenerate dentin-like tissue, which was confirmed by the presence of collagenous matrix, odontoblast specific markers and calcified deposits. Gene Therapy (2006) 13, 611-620.

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“…But, the results did not change in a concentration-dependent manner. It has been reported that tertiary dentin was induced by direct pulp capping with conventional calcium hydroxide have the tunnel-shaped defects present in approximately 90% 12,13) , and about 40% of them cause pulpitis 37) . These results suggest quality of the tertiary dentin becomes necessary conditions may not cause degeneration of the pulp and pulp reinfection by leakage through the loss of tertiary dentin.…”

Section: Discussionmentioning

confidence: 99%

“…However, calcium hydroxide has highly alkaline (pH12), which can be formed below of pulp necrosis following cause chronic inflammation and formed internal absorption layer. To make matters worse, the tertiary dentin which is formed so as to cover the surface of exposed pulp as a protective response have such as defects and tunnel-like shaped, their presence will be caused for deterioration of pulp disease [12][13][14][15] . Therefore, development of highly secure direct pulp capping agent to induce the high quality tertiary dentin more effectively has been demanded.…”

Section: Introductionmentioning

confidence: 99%

The possibility of genistein as a new direct pulp capping agent

et al. 2013

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Genistein, kind of soy isoflavones, is well-known as natural ingredients and consumed as health foods and supplements. They are expected to improve renal function. They have high-affinity to estrogen receptor β expressed predominantly in bone tissue, they prevent osteoporosis specifically and safely. We examined whether genistein can be a new direct capping agent. In this study, we examined the effect of genistein for the proliferation and differentiation of rat dental pulp cells in vitro and the ability of tertiary dentin formation in vivo. As a result, rat dental pulp cells with genistein were increased activity of ALPase and showed alizarin red positive-staining. Calcification-related genes expression has been confirmed by the addition of genistein. From in vivo study, high quality of tertiary dentin formation and minor pulp reaction were observed. From these findings, it was suggested that genistein may be useful agent for direct pulp capping.

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Pulp capping of dental pulp mechanically exposed to oral microflora: a 1–2 year observation of wound healing in the monkey

Cited by 178 publications

References 19 publications

Diametral tensile strength of novel fast-setting calcium silicate cement

Diametral tensile strength of novel fast-setting calcium silicate cement

Dentin matrix protein 1 induces cytodifferentiation of dental pulp stem cells into odontoblasts

The possibility of genistein as a new direct pulp capping agent

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