Pulsatile drug delivery systems

Lalwani, Anita; Santani, DD

doi:10.4103/0250-474x.36932

Cited by 13 publications

(8 citation statements)

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“…These hydrogels may respond rapidly to small changes in pH and temperature and recently have been shown to also respond to a change in light intensity, ionic strength, magnetism, inflammation, ultrasound, electric fields and even certain biochemicals (e.g. glucose, urea) [2,[7][8][9]. These 'smart' hydrogels may be synthesized in the conventional manner to result in hydrogels with small pore sizes or they may be synthesized by various other approaches to result in macroporous hydrogels for different applications [10,11].…”

Section: Covalently Cross-linked Reversible and Physical Gelsmentioning

confidence: 99%

Stimuli-responsive polymers and their applications in drug delivery

Bawa

Pillay

Choonara³

et al. 2009

Biomed. Mater.

574

363

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Interest in stimuli-responsive polymers is steadily gaining increasing momentum especially in the fields of controlled and self-regulated drug delivery. Delivery systems based on these polymers are developed to closely resemble the normal physiological process of the diseased state ensuring optimum drug release according to the physiological need. Also termed 'environmental-sensitive' or 'smart', these polymers experience rapid changes in their microstructure from a hydrophilic to a hydrophobic state triggered by small changes in the environment. The changes are reversible; therefore, the polymer is capable of returning to its initial state as soon as the trigger is removed. Stimuli may occur internally (e.g. a change in pH in certain organs or diseased states, a change in temperature or the presence of specific enzymes or antigens). External stimuli include magnetic or electric fields, light, ultrasound, etc. This review will delve into the various internally and externally stimuli-responsive polymers and the drug delivery systems that exploit them.

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Section: Covalently Cross-linked Reversible and Physical Gelsmentioning

confidence: 99%

Stimuli-responsive polymers and their applications in drug delivery

Bawa

Pillay

Choonara³

et al. 2009

Biomed. Mater.

574

363

View full text Add to dashboard Cite

show abstract

“…These include asthma, arthritis, duodenal ulcer, cancer, cardiovascular diseases, diabetes, neurological disorders, etc. The use of temperature as a stimulus has been justified by the fact that the body temperature often deviates from the physiological temperature in the presence of pathogens or pyrogens [3]. Thermosensitive pulsatile drug delivery has been developed based on this view.…”

Section: Introductionmentioning

confidence: 99%

Photopolymerised thermo-responsive poly(N,N-diethylacrylamide)-based copolymer hydrogels for potential drug delivery applications

et al. 2012

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Novel thermo-sensitive N,N-diethylacrylamide (DEAAm) based copolymer hydrogels were prepared via UV-induced free radical bulk polymerisation. UV polymerisation was employed to avoid the use of potentially toxic solvents; solution polymerisation has been the most common means for the preparation of PDEAAm-based hydrogels in the literature to date. The resultant hydrogels were analysed using nuclear magnetic resonance, Fourier transform infrared spectroscopy and modulated differential scanning calorimetry. Parameters such as the crosslinking degree and the nature of the incorporated hydrophilic component, N-vinyl-2-pyrrolidone (NVP) or N,N-dimethylacrylamide (DMAAm) were found to impact hydrogel structure, mechanical properties and swelling kinetics. Pulsatile swelling studies indicated that the hydrogels had thermo-reversible properties which were greatly affected by test temperature, nature of hydrophilic monomer used and crosslinker content. Aminophylline was selected as a model solute for drug loading and release studies by thermal deswelling in HCl buffer (pH 1.4) and phosphate buffer media (pH 6.8). The observed lag time prior to significant drug release from the more crosslinked P(DEAAm-NVP) hydrogels could make them suitable for delayed specific release in the intestine and potential alternatives to layers or membranes in timespecific and site-specific swelling-controlled drug delivery systems.

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“…Hence, there is a time lag before the drug can be released corresponding to the time required for critical molecular weight to be reached. A number of research groups have investigated purposed formulation by using this system 12 , 13 …”

Section: Classification Of Pulsatile Drug Delivery Systemsmentioning

confidence: 99%

Recent technologies in pulsatile drug delivery systems

et al. 2011

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Pulsatile drug delivery systems (PDDS) have attracted attraction because of their multiple benefits over conventional dosage forms. They deliver the drug at the right time, at the right site of action and in the right amount, which provides more benefit than conventional dosages and increased patient compliance. These systems are designed according to the circadian rhythm of the body, and the drug is released rapidly and completely as a pulse after a lag time. These products follow the sigmoid release profile characterized by a time period. These systems are beneficial for drugs with chronopharmacological behavior, where nocturnal dosing is required, and for drugs that show the first-pass effect. This review covers methods and marketed technologies that have been developed to achieve pulsatile delivery. Marketed technologies, such as PulsincapTM, Diffucaps®, CODAS®, OROS® and PULSYSTM, follow the above mechanism to render a sigmoidal drug release profile. Diseases wherein PDDS are promising include asthma, peptic ulcers, cardiovascular ailments, arthritis and attention deficit syndrome in children and hypercholesterolemia. Pulsatile drug delivery systems have the potential to bring new developments in the therapy of many diseases.

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Pulsatile drug delivery systems

Cited by 13 publications

References 0 publications

Stimuli-responsive polymers and their applications in drug delivery

Stimuli-responsive polymers and their applications in drug delivery

Photopolymerised thermo-responsive poly(N,N-diethylacrylamide)-based copolymer hydrogels for potential drug delivery applications

Recent technologies in pulsatile drug delivery systems

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