Pulsatile ocular blood flow in diabetic retinopathy

Kau²,

et al. 2005

Eye

Purpose Our previous study has demonstrated an impairment of pulsatile ocular blood flow (POBF) in patients with Graves'ophthalmopathy (GO). Here we further evaluate the haemodynamic change in GO patients after systemic steroid. Methods In a prospective, interventional, consecutive clinical case series, all patients with active and moderately severe GO who underwent systemic steroid treatment were evaluated. The change of POBF and the clinical activity and severity of the disease were assessed. Results In total, 11 patients underwent intravenous methylprednisolone pulse therapy followed by 2-month oral prednisolone therapy. POBF improved from a mean value of 476.5 to 614.7 ll/min (Po0.001) after treatment. Likewise, the mean clinical activity score reduced from 4.8 to 1.6. However, systemic steroid had less effect on the severity of GO. It also revealed that there is a greater improvement of POBF in those with more clinical activity score (44) at the onset. Conclusions Following treatment with systemic steroid we have demonstrated a significant improvement in POBF in patients with GO.

Section: Discussionmentioning

confidence: 90%

Pulsatile ocular blood flow change after treatment with systemic steroid in patients with Graves' ophthalmopathy

Kau²,

et al. 2005

Eye

“…The pulsatile component of ocular blood flow is primarily choroidal. 5 It has been clinically applied to investigate in various ocular diseases including glaucoma, 6,7 age-related macular degeneration, 8,9 diabetic retinopathy, 10,11 choroidal melanoma, 12 and retinal pigmentosa. 13 Graves' disease (GD) is an autoimmune disorder characterized by hyperthyroidism, diffuse goitre, ophthalmopathy, and rarely, dermopathy.…”

Section: Introductionmentioning

confidence: 99%

Pulsatile ocular blood flow in patients with Graves' ophthalmopathy

Kau

Kao

et al. 2004

Eye

Purpose Graves' ophthalmopathy (GO) is a cosmetically disfiguring and visionthreatening complication of Graves' disease (GD). We investigated the clinical application of pulsatile ocular blood flow (POBF) measurement for detection of clinically active GO. Methods In this prospective study, the OBF tonometer (OBF Labs, Wiltshire, UK) was used to measure POBF in 83 eyes of 83 patients with GD in two groups and 42 normal control subjects. Group A comprised 35 GD patients without ophthalmopathy, and group B composed 48 GD patients with ophthalmopathy. Results were compared with controls. Results Pulse amplitude, pulse volume, and POBF were significantly lower in group B than that in group A and controls (Po0.001). After adjusting for age, sex, systolic blood pressure, diastolic blood pressure, heart rate, intraocular pressure, and axial length, multivariate linear regression analysis showed that POBF was still significantly lower in eyes with GO (772.4 (SD 279.3) ll/min) than group A (1177.3 (SD 326.3) ll/min) and controls (1255.4 (SD 295.1) ll/min) (Po0.001). Conclusions These data show that the pulsatile ocular blood flow differences between the groups are relevant to the presence of GO. POBF measurement is a clinically useful adjunct for assessing the haemodynamic change in GO patients.

“…POBF assessment may be of clinical importance in the detection and monitoring of several eye diseases. It has been found to be reduced A study comparing ocular pressure pulse and ocular fundus pulse in dependence of axial eye length and ocular volume in glaucoma (Perkins 1981a;Quaranta et al 1994;Stalmans et al 2008) and characteristically altered in other vascular-related ocular pathology, such as diabetic retinopathy (MacKinnon et al 1997;Geyer et al 1999) and exudative age-related maculopathy (Mori et al 2001a). In recent years there has been increased interest in the interpretation of the ocular pulse amplitude, because it is measured easily using dynamic contour tonometry (Punjabi et al 2006a(Punjabi et al , 2006b).…”

Section: Introductionmentioning

confidence: 99%

A study comparing ocular pressure pulse and ocular fundus pulse in dependence of axial eye length and ocular volume

Berisha

Findl

Lasta

et al. 2010

Acta Ophthalmologica

ABSTRACT.Purpose: There is a long-standing discussion about whether myopia is associated with decreased choroidal blood flow, as suggested by pneumotonometric measurements of pulsatile ocular blood flow (POBF). However, it has been noted previously that calculations of POBF depend on intraocular volume. Methods: In the present study we investigated this volume dependence through the comparison of ocular pressure pulse and ocular fundus pulse. Fifty-one healthy participants with different refractive errors participated in the study. Pulse amplitude (PA) and POBF were measured using pneumotonometry. Fundus pulsation amplitude (FPA) was measured with laser interferometry. Axial eye length (AEL) was measured with partial coherence interferometry. A mathematical model was used to calculate choroidal volume changes based on FPA. The ocular pressure pulse was converted into pulse volume (PV) according to the standard procedure used for pneumotonometry. Results: PA and POBF were found to decrease with increasing axial length (r = )0.55, p < 0.001 and r = )0.57, p < 0.001, respectively). A similar relationship existed for PV (r = )0.57, p < 0.001) and FPA (r = )0.46, p = 0.001). In addition, there was a significant association between PV and choroidal volume change during the cardiac cycle (r = 0.61, p < 0.001). Conclusion: The present study confirms experimentally that PA, FPA and POBF are dependent on ocular volume and indicates that the pulsatile component of ocular blood flow is not reduced in myopic patients. Accordingly, the relationship between AEL and POBF described previously appears to be a consequence of different ocular volumes. Our findings have important implications for studies using PA or POBF.