Pulse Pressure Wave Analysis in the Diagnosis of Aorto-iliac Disease

Leveson, Stephen H.; Guillou, P. J.; Terry, H J; Glanville, J. N.; Kester, R. C.

doi:10.1097/00000658-197802000-00011

Cited by 16 publications

(7 citation statements)

References 5 publications

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“…These abnormalities will produce interfaces that can reflect propagating waves as shown with pulse wave measurements (19). With this in mind, we created focal circumferential narrowing within the thinwalled latex model vessel to assess the ability of the technique to predict the degree of stenosis.…”

Section: Resultsmentioning

confidence: 99%

“…The MRE method is able to image cyclic displacements with very small amplitude and to track these waves, especially within naturally occurring wave guides (18). Because the arteries serve as a natural wave guide, the technique is well suited for imaging the arterial system (19). Furthermore, early physiologic and pressure wave studies demonstrate a change in the conduction of this natural pulse wave with atherosclerotic disease (19).…”

mentioning

confidence: 99%

“…Because the arteries serve as a natural wave guide, the technique is well suited for imaging the arterial system (19). Furthermore, early physiologic and pressure wave studies demonstrate a change in the conduction of this natural pulse wave with atherosclerotic disease (19).…”

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confidence: 99%

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Vascular wall elasticity measurement by magnetic resonance imaging

Woodrum

Romano

Lerman

et al. 2006

Magnetic Resonance in Med

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The goal of this current study was to determine whether an MRI-based elastography (MRE) method can visualize and assess propagating mechanical waves within fluid-filled vessels and to investigate the feasibility of measuring the elastic properties of vessel walls and quantitatively assessing stenotic lesions by using MRE. The ability to measure the Young's modulus-wall thickness product was tested using a thin-walled latex vessel model. Also tested in vessel models was the ability to quantitate the degree of stenosis by measuring transmitted and reflected mechanical waves. This method was then applied to ex vivo porcine models and in vivo human arteries to further test its feasibility. The results provide preliminary evidence that MRE can be used to quantitatively assess the stiffness of blood vessels, and provide a non-morphologic method to measure stenosis. With further development, it is possible that the method can be implemented in vivo. Magn Reson Med 56: 593-600,

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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Vascular wall elasticity measurement by magnetic resonance imaging

Woodrum

Romano

Lerman

et al. 2006

Magnetic Resonance in Med

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“…The developed phase contrast MRI-based elastography technique can image micron-amplitude propagating waves induced in the walls of blood vessels by harmonic mechanical stimulation at acoustic frequencies and can be used to quantify vascular wall stiffness (10-12). Additionally, it is also able to determine very small changes in wall thickness and elasticity as determined in model systems (10).…”

mentioning

confidence: 99%

Phase‐contrast MRI‐based elastography technique detects early hypertensive changes in ex vivo porcine aortic wall

Woodrum¹,

Herrmann²,

Lerman³

et al. 2009

Magnetic Resonance Imaging

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Purpose: To measure the elastic properties of ex vivo porcine aortas in control and hypertensive groups using a phase contrast magnetic resonance imaging (MRI)-based elastography technique. Materials and Methods:Female domestic pigs were randomized to a normal control group (N; n ϭ 5) or a renovascular hypertension group (HT; n ϭ 5) for the duration of 3 months. Mean arterial pressure was significantly higher in the hypertension group than in the control group (173 Ϯ 12 vs. 115 Ϯ 11 mmHg, P Յ 0.05). The animals were euthanized after 3 months of hypertension and abdominal aortas harvested. The ex vivo aortic samples were then examined using a phase-contrast MRI-based elastography technique. Results:The Young's modulus-wall thickness product, a reflection of vascular stiffness, was significantly higher in the hypertension group than in the control group (0.571 Ϯ 0.080 vs. 0.419 Ϯ 0.026, P Ͻ 0.05). Histological analysis and staining confirmed increased intima-media thickness and collagen content in the hypertensive aorta, while elastin staining showed no difference. Conclusion:The current study shows that MR elastography offers a method to study the physiologic changes in the arterial wall secondary to early hypertension.

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“…The control group consisted of healthy age-, sex-, and weight-matched normal controls. Resting and exercise electrocardiograms, blood 26 and cardiac contractility. 49 Descending slope was defined by the elements KE/DE.…”

Section: Patientsmentioning

confidence: 99%

Resting and Exercise Hyperemic Pulsatile Arterial Blood Flow in Insulin-dependent Diabetic Subjects

et al. 1983

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Pulsatile arterial blood flow was studied in 20 normal (N), 20 short-term (STIDDM; mean: 5.17 yr), and 20 long-term insulin-dependent diabetic patients (LTIDDM; mean: 14.76 yr) between the ages of 18 and 30 yr with no clinically detectable peripheral vascular disease. Measurements were taken from waveforms obtained noninvasively using an electromagnetic flowmeter at rest and immediately after a 3-min isometric exercise challenge of the right leg. At rest, both groups of diabetics exhibited minute flow values similar to those in the normal group. This was achieved, however, by increased vasodilation in peripheral tissues as indicated by a difference in waveform configuration. Diabetic subjects showed a significantly smaller peak flow, a less steep ascending and descending slope, and a higher minute heart rate than normal controls. After 3 min of isometric exercise, the diabetic groups exhibited significantly less minute flow, flow/pulse, and a more vasodilated flow pattern similar to that recorded at rest. In addition, the LTIDDM group showed significantly less arterial elasticity than N or STIDDM groups as indicated by a shorter propagation time. These findings imply that apparent functional changes in pulsatile arterial blood flow occur early in the time course of diabetes and are independent of duration.

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Pulse Pressure Wave Analysis in the Diagnosis of Aorto-iliac Disease

Cited by 16 publications

References 5 publications

Vascular wall elasticity measurement by magnetic resonance imaging

Vascular wall elasticity measurement by magnetic resonance imaging

Phase‐contrast MRI‐based elastography technique detects early hypertensive changes in ex vivo porcine aortic wall

Resting and Exercise Hyperemic Pulsatile Arterial Blood Flow in Insulin-dependent Diabetic Subjects

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