Pulsed electromagnetic fields after intramedullary nailing of tibial fractures: a case control study

Buono, Angelo Del; Zampogna, Biagio; Osti, Leonardo; Fontanarosa, Alberto; Garofalo, Raffaele; Papalia, Rocco

doi:10.1007/s00264-021-05125-y

Cited by 11 publications

(4 citation statements)

References 32 publications

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“…Therefore, we suggest that important pathways and mechanisms for neutrophil activation and neutrophil defense mechanisms are not negatively affected by 16 Hz ELF-PEMF exposure. This supports the safety of ELF-PEMF usage in clinical settings [51,52], where diverse complications with different molecular mechanisms can occur.…”

Section: Discussionsupporting

confidence: 71%

NET Formation Was Reduced via Exposure to Extremely Low-Frequency Pulsed Electromagnetic Fields

Linnemann,

Sahin,

Chen

et al. 2023

IJMS

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Fracture-healing is a highly complex and timely orchestrated process. Non-healing fractures are still a major clinical problem and treatment remains difficult. A 16 Hz extremely low-frequency pulsed electromagnetic field (ELF-PEMF) was identified as non-invasive adjunct therapy supporting bone-healing by inducing reactive oxygen species (ROS) and Ca2+-influx. However, ROS and Ca2+-influx may stimulate neutrophils, the first cells arriving at the wounded site, to excessively form neutrophil extracellular traps (NETs), which negatively affects the healing process. Thus, this study aimed to evaluate the effect of this 16 Hz ELF-PEMF on NET formation. Neutrophils were isolated from healthy volunteers and exposed to different NET-stimuli and the 16 Hz ELF-PEMF. NETs were quantified using Sytox Green Assay and immunofluorescence, Ca2+-influx and ROS with fluorescence probes. In contrast to mesenchymal cells, ELF-PEMF exposure did not induce ROS and Ca2+-influx in neutrophils. ELF-PEMF exposure did not result in basal or enhanced PMA-induced NET formation but did reduce the amount of DNA released. Similarly, NET formation induced by LPS and H2O2 was reduced through exposure to ELF-PEMF. As ELF-PEMF exposure did not induce NET release or negatively affect neutrophils, the ELF-PEMF exposure can be started immediately after fracture treatment.

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Section: Discussionsupporting

confidence: 71%

NET Formation Was Reduced via Exposure to Extremely Low-Frequency Pulsed Electromagnetic Fields

Linnemann,

Sahin,

Chen

et al. 2023

IJMS

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“…Studies conducted on osteoporosis-induced rats or mice (ovariectomized) have demonstrated improvements in bone mass, bone mineral density, and bone microarchitecture [ 15 , 16 ]. Additionally, a wealth of research indicates accelerated fracture healing with PEMF therapy [ 12 – 14 ]. Potential mechanisms for these effects include increased osteoblast activity, enhanced osteoblast differentiation, inhibition of osteoclasts, and induction of angiogenesis [ 26 – 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…One specific type of electromagnetic wave therapy is PEMF (pulsed electromagnetic field) therapy, which gained approval from the Food and Drug Administration (FDA) in 1979. PEMF devices have been used as a modality for treating various osteogenic disorders, including fracture healing [ 12 – 14 ] or reducing bone loss associated with osteoporosis [ 15 , 16 ]. EMTT, on the other hand, is a newer device that falls within the category of electromagnetic treatment.…”

Section: Introductionmentioning

confidence: 99%

Clavicle fracture and triathlon performance: a case report

Gerdesmeyer,

Burgkart,

Saxena

2024

J Med Case Reports

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Background Collarbone fracture is a common injury, particularly among athletes involved in contact sports and participating in endurance activities. Conventional treatment requires surgery and postoperative immobilization, resulting in an average return-to-sport timeframe of approximately 13 weeks. This case challenges the established treatment protocols, aiming to expedite recovery and enable a quicker resumption of high-intensity athletic activities. Case presentation A 24-year-old Caucasian athlete completed a Half-Ironman Triathlon (70.3) merely three weeks post-collarbone fracture. Utilizing Extracorporeal Magneto-Transduction Therapy (EMTT) alongside surgical intervention, the patient achieved accelerated healing and remarkable performance outcomes without encountering any adverse effects. Conclusions The integration of EMTT into the treatment paradigm for bone fractures alters the traditional understanding of recovery timelines and rehabilitation strategies. This case highlights the potential benefits of electromagnetic wave therapy in expediting the healing process and enabling athletes to resume high-level sports activities at an earlier stage.

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“…PEMF treatment was widely used in healing of the bone and PEMF treatment (3.8 kHz, 2 mT, 3 h/day) accelerated the healing of bone trauma in adult male Sprague–Dawley (SD) rats with fibular osteotomies [Midura et al, 2005]. After intramedullary nailing of tibial fractures treated with PEMF (75 Hz, 1.5 mT，6–8 h/day), patients had a shorter time of fracture healing and better clinical and functional outcomes [Del Buono et al, 2021].…”

Section: Introductionmentioning

confidence: 99%

Effect of the Pulsed Electromagnetic Field Treatment in a Rat Model of Senile Osteoporosis In Vivo

Zhou

Wang

et al. 2022

Bioelectromagnetics

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This study assessed the effects of pulsed electromagnetic fields (PEMF) in a rat model of senile osteoporosis and the underlying molecular events. 24-month-old male Sprague-Dawley (SD) rats were randomly divided into control and PEMF groups (n = 8 per group) using a random digit table, while 3month-old male SD rats were set as the young-age control group. Rats in the PEMF group were treated by PEMF for 40 min/day for 5 days/week. Bone mineral density/microarchitecture, level of serum bonespecific alkaline phosphatase (BALP), tartrate-resistant acid phosphatase 5b (TRACP5b), and Wnt/βcatenin signaling genes in rat bone marrow cells were then analyzed. The 12-week PEMF intervention showed a significant effect on inhibition of age-induced bone density loss and deterioration of trabecular bone structures in the PEMF group rats versus control rats, that is, the treatment enhanced bone mineral density of the proximal femoral metaphysis and the fifth lumbar (L5) vertebral body and improved the proximal tibia and L4 vertebral body parameters using bone histomorphometry analysis. Furthermore, the BALP level in the bones was significantly increased, but the TRACP5b level was reduced in the PEMF group of rats versus control rats. PEMF also dramatically upregulated expression of Wnt3a, LRP5, β-catenin, and Runx2 but downregulated PPAR-γ expression in the aged rats. The results demonstrated that PEMF could prevent bone loss and architectural deterioration due to the improvement of bone marrow mesenchymal stromal cell differentiation and proliferation abilities and activating the Wnt signaling pathway. Future clinical studies are needed to validate these findings. Bioelectromagnetics. 43:438-447, 2022.

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Pulsed electromagnetic fields after intramedullary nailing of tibial fractures: a case control study

Cited by 11 publications

References 32 publications

NET Formation Was Reduced via Exposure to Extremely Low-Frequency Pulsed Electromagnetic Fields

NET Formation Was Reduced via Exposure to Extremely Low-Frequency Pulsed Electromagnetic Fields

Clavicle fracture and triathlon performance: a case report

Effect of the Pulsed Electromagnetic Field Treatment in a Rat Model of Senile Osteoporosis In Vivo

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