Pulsed electromagnetic fields attenuate glucocorticoid-induced bone loss by targeting senescent LepR+ bone marrow mesenchymal stromal cells

Wang, Tiantian; Yang, Lin; Liang, Zejun; Bai, Lin; Pei, Hongliang; Zhang, Tianxiao; Wu, Lei; Lin, Wei; Wang, Xiangxiu; You, Xuanhe; He, Chengqi

doi:10.1016/j.msec.2021.112635

Cited by 11 publications

(10 citation statements)

References 48 publications

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“…Qian Wang et al found that PEMFs promote osteogenesis by promoting the formation of H-type blood vessels which inhibits the occurrence of osteoporosis [ 44 ]. Tiantian Wang et al also found that, as a potential treatment for glucocorticoid-induced osteoporosis, PEMFs maintain H-type angiogenesis and osteogenesis [ 45 ].…”

Section: Pemfs For Osteoporosismentioning

confidence: 99%

The Possible Role of Electrical Stimulation in Osteoporosis: A Narrative Review

Zhang

Luo

et al. 2023

Medicina

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Osteoporosis is mainly a geriatric disease with a high incidence, and the resulting spinal fractures and hip fractures cause great harm to patients. Anti-osteoporosis drugs are the main treatment for osteoporosis currently, but these drugs have potential clinical limitations and side effects, so the development of new therapies is of great significance to patients with osteoporosis. Electrical stimulation therapy mainly includes pulsed electromagnetic fields (PEMF), direct current (DC), and capacitive coupling (CC). Meanwhile, electrical stimulation therapy is clinically convenient without side effects. In recent years, many researchers have explored the use of electrical stimulation therapy for osteoporosis. Based on this, the role of electrical stimulation therapy in osteoporosis was summarized. In the future, electrical stimulation might become a new treatment for osteoporosis.

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Section: Pemfs For Osteoporosismentioning

confidence: 99%

The Possible Role of Electrical Stimulation in Osteoporosis: A Narrative Review

Zhang

Luo

et al. 2023

Medicina

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“…Furthermore, Jun treatment can relieve osteoporosis in mice through activating the osteogenesis capacity of Thy + /6c3 − BMSCs [ 116 ]. Pulsed electromagnetic fields (PEMFs) attenuated the senescence of LepR + BMSCs to prevent bone loss in glucocorticoid-induced osteoporosis [ 117 ]. Mechanically, PEMFs trigger a high level of EZH2- H3K27me3 in LepR + BMSCs for an anti-senescence effect [ 117 ].…”

Section: Functional Heterogeneity Of Bmsc Subpopulations In Pathologymentioning

confidence: 99%

“…Pulsed electromagnetic fields (PEMFs) attenuated the senescence of LepR + BMSCs to prevent bone loss in glucocorticoid-induced osteoporosis [ 117 ]. Mechanically, PEMFs trigger a high level of EZH2- H3K27me3 in LepR + BMSCs for an anti-senescence effect [ 117 ].…”

Section: Functional Heterogeneity Of Bmsc Subpopulations In Pathologymentioning

confidence: 99%

Functional Heterogeneity of Bone Marrow Mesenchymal Stem Cell Subpopulations in Physiology and Pathology

Ning

Chen

et al. 2022

IJMS

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Bone marrow mesenchymal stem cells (BMSCs) are multi-potent cell populations and are capable of maintaining bone and body homeostasis. The stemness and potential therapeutic effect of BMSCs have been explored extensively in recent years. However, diverse cell surface antigens and complex gene expression of BMSCs have indicated that BMSCs represent heterogeneous populations, and the natural characteristics of BMSCs make it difficult to identify the specific subpopulations in pathological processes which are often obscured by bulk analysis of the total BMSCs. Meanwhile, the therapeutic effect of total BMSCs is often less effective partly due to their heterogeneity. Therefore, understanding the functional heterogeneity of the BMSC subpopulations under different physiological and pathological conditions could have major ramifications for global health. Here, we summarize the recent progress of functional heterogeneity of BMSC subpopulations in physiology and pathology. Targeting tissue-resident single BMSC subpopulation offers a potentially innovative therapeutic strategy and improves BMSC effectiveness in clinical application.

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“…Cellular senescence is a cell state implicated in various physiological processes and has been associated with a wide range of age‐related diseases, 9 with senescent cells and heterogeneous cellular states associated with senescence‐associated secretory phenotype (SASP) of particular interest. Targeting senescent bone cells and SASP has been shown to alleviate OP 10–13 . Although promising, the mechanistic relationships among cellular senescence, SASP and OP pathology are unclear 14–18 …”

Section: Introductionmentioning

confidence: 99%

“…Targeting senescent bone cells and SASP has been shown to alleviate OP. [10][11][12][13] Although promising, the mechanistic relationships among cellular senescence, SASP and OP pathology are unclear. [14][15][16][17][18] The purpose of this review is to summarize recent findings regarding the roles of bone cellular senescence and SASP in OP.…”

mentioning

confidence: 99%

Senescent cells: A therapeutic target for osteoporosis

Wang

Huang

2022

Cell Proliferation

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Background Osteoporosis (OP) is a prevalent disorder characterized by the loss of bone mass and the deterioration of bone microarchitecture. OP is attributed to various factors, including menopause (primary), ageing (primary) and the adverse effects of medications (secondary). Recently, cellular senescence has been shown to have a crucial role in the maintenance of cellular homeostasis and organ function. The purpose of this review is to summarize recent findings regarding the roles of bone cellular senescence and senescence‐associated secretory phenotype (SASP) in OP. Methods A comprehensive search of the PubMed database from inception to July 2022 was performed regarding the molecular mechanism of bone cell senescence in OP progression. Results We describe the pathophysiology of senescent bone cells and SASP, and how each contributes to OP. We also provide new options for treating OP by targeting cellular senescence pathways. Conclusion Cellular senescence plays an important role in bone homeostasis, with variations based on the different types of OP. These variations are associated with pathogenic factors, bone turnover rate and systemic metabolism. Understanding the molecular relationship between bone cells and senescence provides for the possible targeting of senescence as a means by which to treat OP.

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Pulsed electromagnetic fields attenuate glucocorticoid-induced bone loss by targeting senescent LepR+ bone marrow mesenchymal stromal cells

Cited by 11 publications

References 48 publications

The Possible Role of Electrical Stimulation in Osteoporosis: A Narrative Review

The Possible Role of Electrical Stimulation in Osteoporosis: A Narrative Review

Functional Heterogeneity of Bone Marrow Mesenchymal Stem Cell Subpopulations in Physiology and Pathology

Senescent cells: A therapeutic target for osteoporosis

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