Pure clear cell papillary thyroid carcinoma with chronic thyroiditis: Report of a case

Asanuma, Kazuhiko; Sugenoya, Akira; Ohashi, Toujirou; Nagai, Noriyoshi; Itoh, Nobuo; Kobayashi, Shinya; Amano, Jun

doi:10.1007/s005950050166

Cited by 9 publications

(3 citation statements)

References 6 publications

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“…Clear cell PTC can demonstrate papillary, follicular, or insular growth patterns. The cytoplasmic clearing may be the result of accumulation of glycogen or mitochondrial dilatation . However, glycogen accumulation accounts for most cases of clear cell cytoplasmic change in PTC .…”

Section: Discussionmentioning

confidence: 99%

“…The cytoplasmic clearing may be the result of accumulation of glycogen or mitochondrial dilatation. 24 However, glycogen accumulation accounts for most cases of clear cell cytoplasmic change in PTC. 17,25 The biological behavior depends on the aggressiveness of the nonclear portion of the tumor.…”

Section: Discussionmentioning

confidence: 99%

“…In other areas of the tumor, the hobnail cells demonstrated both clear and nonclear cytoplasm, a finding that has been reported in other cases of clear cell thyroid tumors. Previously published cases of clear cell PTC have been of the classic type, 17,23 follicular variant, 24 and oncocytic variant. 25 This case represents another variant of PTC in which clear cells can be observed.…”

Section: Discussionmentioning

confidence: 99%

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Cytological features of clear cell thyroid tumors, including a papillary thyroid carcinoma with prominent hobnail features

Yang

Fried

Scognamiglio

2012

Diagnostic Cytopathology

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Primary thyroid tumors with extensive clear cell changes are extremely rare. More than 10,000 ultrasound-guided thyroid fine needle aspirations examined over a period of 17 years by the first author, only one of the 530 (<0.2%) papillary thyroid carcinomas (PTCs) and three of the 42 (7.1%) follicular thyroid carcinomas (FTCs) had extensive cytoplasmic clearing. Thyroidectomies were performed for these cases at four different hospitals in New York City. Final pathology was available for review in each of the four cases. Histology showed a 1.5-cm PTC with prominent hobnail features and clear cell change in a 31-year-old woman, a 4.3-cm FTC without angioinvasion in a 31-year-old woman, a 4.5-cm angioinvasive FTC in a 45-year-old man, and a 2-cm FTC with extensive angioinvasion in a 41-year-old woman with McCune-Albright syndrome (previously published). On ultrasound, the FTCs were solid circumscribed nodules and the PTC had an irregular margin. In these cases, the etiology for the cytoplasmic clearing included accumulation of glycogen in the PTC, accumulation of vesicles in two of the FTCs, and accumulation of lipid droplets in a FTC with extensive angioinvasion. Review of the cytologic literature showed 17 cases of follicular-derived thyroid tumors with extensive clear cell change. To the best of our knowledge, this is the first cytologic report of PTC with hobnail features and extensive clear cell change.

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Section: Discussionmentioning

confidence: 99%