Pure Obstructive Sleep Apnea Syndrome and Erectile Dysfunction

Gürbüz, Cenk; Okur, Hacer Kuzu; Demir, Selamettin; Ordu, Salih; Çaşkurlu, Turhan

doi:10.5152/balkanmedj.2011.011

Cited by 5 publications

(11 citation statements)

References 34 publications

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“…Agreement between the reviewers was good (Kappa statistic = 0.68). All of them were found to be observational studies [22,[29][30][31][32][44][45][46][47].…”

Section: Literature Searchmentioning

confidence: 99%

“…Sample size of the studies ranged from 32 to 401 patients. There were five casecontrol studies [29,31,44,45,47], three cohort studies [22,30,32], and one cross-section study [46]. Three of the included studies were conducted in the United States [22,29,44]; four were in Europe (Germany, Sweden, Greece and Italy) [30][31][32]46]; and two were in Asia (Korea and Turkey) [45,47].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Of the nine studies, five [22,[44][45][46][47] reported incidence of ED, and the remaining four [26][27][28][29] reported incidence of FSD. The denominator was OSA and was diagnosed by the Epworth Sleepiness Scale (ESS) scores and polysomnography findings.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Sexual Dysfunction in Patients with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Liu

Kang²,

Zhao³

et al. 2015

The Journal of Sexual Medicine

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Introduction Sexual dysfunction is an under-recognized problem in men and women with obstructive sleep apnea (OSA). Epidemiologic findings were inconclusive regarding the risk for sexual dysfunction associated with OSA. Aim The aim of this study was to examine the association between OSA and sexual dysfunction. Methods The PubMed, Cochrane Library, and Embase databases were searched for observational studies on the OSA and the risk of sexual dysfunction. The methodologic quality of the case–control and cohort studies was assessed with Newcastle–Ottawa Scale (NOS). The cross-sectional study quality methodology checklist was used for cross-sectional study. Data were pooled for the random-effects model. Sensitivity analyses were conducted to assess potential bias. Main Outcome Measure The association between OSA and sexual dysfunction was summarized using relative risk (RR) with a 95% confidence interval (CI). Results This meta-analysis included 1,275 participants from nine studies. Five studies reported the incidence of erectile dysfunction (ED); the remaining four studies reported the incidence of female sexual dysfunction (FSD). Pooled results demonstrated that OSA was associated with increased risk of ED (pooled RR = 1.82, 95% CI: 1.12–2.97) as well as FSD (pooled RR = 2.00, 95% CI: 1.29–3.08). Estimates of the total effects were generally consistent in the sensitivity analysis. No evidence of publication bias was observed. Conclusions Evidence from the observational studies suggested that OSA individuals might have an increased incidence of sexual dysfunction despite significant heterogeneity. More researches are warranted to clarify the relationship between OSA and the increased risk of sexual dysfunction.

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“…Agreement between the reviewers was good (Kappa statistic = 0.68). All of them were found to be observational studies [22,[29][30][31][32][44][45][46][47].…”

Section: Literature Searchmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Sexual Dysfunction in Patients with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Liu

Kang²,

Zhao³

et al. 2015

The Journal of Sexual Medicine

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“…Indeed, patients with SDB may suffer disproportionately from ED when compared to the general population 8 . The high prevalence of ED among SDB patients may be due to this confluence of risk factors and co-morbidities rather than to SDB itself 9 . However, others suggest that SDB may independently lead to ED, through SDB-related hypoxia and sleep fragmentation that lead to occult pudendal nerve dysfunction and through psychogenic factors 10 .…”

Section: Introductionmentioning

confidence: 98%

“…Published work to date regarding an independent association between SDB and ED is conflicting and limited to studies in middle-aged adults, with only a few studies utilizing the gold standard measure of SDB, polysomnography (PSG) 9,11–13 . Therefore, we performed a cross-sectional analysis in older men to assess the independent association between SDB, as measured by PSG, and prevalent ED among community-dwelling older men participating in the Osteoporotic Fractures in Men (MrOS) Sleep Study.…”

Section: Introductionmentioning

confidence: 99%

Association of Sleep Disordered Breathing with Erectile Dysfunction in Community Dwelling Older Men

et al. 2017

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Purpose To investigate the association between sleep-disordered breathing (SDB) and erectile dysfunction (ED) in older men. Methods We performed a cross-sectional analysis of community-dwelling men aged ≥67 years enrolled in the MrOS Sleep Study. Participants underwent overnight polysomnography (2003–2005) and completed sexual health questionnaires (2005–2006). We defined SDB using the apnea-hypopnea-index (AHI) or nocturnal hypoxemia. ED was defined using the Massachusetts Male Aging Study (MMAS) scale and, in sexually active men, the International Index of Erectile Function (IIEF-5). We used logistic regression to examine the association between SDB and ED. Results Mean age was 76±5 years. Of 2,676 men completing the MMAS, 70% had moderate-to-complete ED. Among 1,099 sexually active men completing the IIEF-5, 26% had moderate-to-severe ED. Higher AHI was associated with greater odds of MMAS-defined moderate-to-complete ED after adjusting for age and study site (OR=1.39; 95%CI: 1.00–1.92 for severe SDB vs none; p-trend=0.008), but not after further adjustment for BMI, socioeconomic status, and co-morbidities (OR=1.05; 95%CI: 0.75–1.49; p trend=0.452). Greater nocturnal hypoxemia was associated with increased odds of MMAS-defined moderate-to-complete ED (unadjusted OR=1.36; 95%Cl: 1.04–1.80 vs none), but this was attenuated after adjustment for age and study site (OR=1.24; 95%CI: 0.92–1.66). SDB was not associated with ED by IIEF-5. Conclusions In this cross-sectional analysis in older men, SDB was associated with higher odds of ED in unadjusted analyses that was largely explained by higher BMI and increased comorbidity among men with SDB. Prospective studies accounting for obesity and multimorbidity would further clarify the association of SDB and ED.

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Prevalence and Characteristics of Erectile Dysfunction in Obstructive Sleep Apnea Patients

et al. 2022

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BackgroundObstructive sleep apnea (OSA) is a common and severe social problem. Erectile dysfunction (ED) is an important health concern. The prevalence of OSA with ED is increasing, which significantly affects the quality of life and work efficiency of patients. However, the mechanism underlying the comorbidity of these two diseases remains unclear.Objectives(1) Investigate the prevalence of OSA with ED; (2) analyze the correlation between OSA and ED; and (3) explore the treatment response to and possible mechanism of uvulapalatopharyngoplasty (UPPP) in patients with OSA and ED. This study aims to provide a theoretical basis for the clinical diagnosis and comprehensive treatment of OSA with ED and improve prevention and treatment strategies.Materials and MethodsIn total, 135 subjects were enrolled in the study. Clinical data, polysomnography, the ESS score, Beck anxiety score, Beck depression score, IIEF-5 score and ASEX score were recorded before UPPP and 6 months after UPPP. Sex hormones were measured for all subjects using a Roche electrochemiluminescence analyzer.ResultThe prevalence of OSA with ED was 64.52%, and the prevalence of severe OSA with ED was 73.02%. The prevalence of OSA with ED increased with age, BMI and apnea-hypopnea index (AHI) value. Among polysomnography indicators, minimum oxygen saturation and average oxygen saturation may predict the occurrence of OSA with ED. Improving the patient’s anxiety and depression is very important for treating OSA with ED. Sex hormone levels were not significantly correlated with the occurrence of OSA with ED.ConclusionED is a common symptom of OSA patients. This study showed that sex hormone levels in OSA patients with ED were not significantly correlated with the condition, but further investigation of this relationship is worthwhile. It is recommended that the free and combined types of sex hormones be further distinguished during testing because the free type is the active form. UPPP surgical treatment is effective for OSA with ED, and its possible mechanism is protection of the peripheral nerves of the sex organs by improving nighttime hypoxia and arousal.

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Pure Obstructive Sleep Apnea Syndrome and Erectile Dysfunction

Cited by 5 publications

References 34 publications

Sexual Dysfunction in Patients with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Sexual Dysfunction in Patients with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis

Association of Sleep Disordered Breathing with Erectile Dysfunction in Community Dwelling Older Men

Prevalence and Characteristics of Erectile Dysfunction in Obstructive Sleep Apnea Patients

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