“pure” primary large cell neuroendocrine carcinoma of the urinary bladder

Pusiol, Teresa; Zorzi, Maria Grazia; Morichetti, Doriana; Sarı, Ayşegül

doi:10.5146/tjpath.2013.01189

Cited by 6 publications

(19 citation statements)

References 14 publications

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“…In clinical terms, lower urinary system symptoms such as hematuria (68.2%), dysuria and obstructive voiding symptoms are observed in small-cell neuroendocrine tumors [ 4 , 5 ]. In a review assessing patients with pure type LCNC, Pusiol et al reported that hematuria was present in 8 out of 11 patients with reported clinical symptoms [ 6 ]. Hematuria and lower urinary system symptoms did not develop in our patient.…”

Section: Discussionmentioning

confidence: 99%

Pure large cell neuroendocrine carcinoma of the bladder without urological symptoms

Akdeniz¹,

Bakırtaş²,

Bolat³

et al. 2018

Pan Afr Med J

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Neuroendocrine carcinoma is one of the uncommonly seen pathologies of the urinary bladder. Macroscopic hematuria is frequently encountered symptom in patients with neuroendocrine carcinoma. We report a 45-year-old man with left solitary kidney and oliguria for five days the development of acute renal failure (ARF) with the impaired general condition. The underlying cause being identified as pure type large-cell neuroendocrine carcinoma of the bladder. Large-cell neuroendocrine carcinoma of the bladder is an uncommon fatal tumor. No macroscopic hematuria or urological symptom was observed in our case. Advanced ectasia was not observed in the kidney, and the patient's clinical status was complicated with ARF. It must not be forgotten that in some bladder tumors, the patient's general condition may be impaired without urological symptoms.

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Section: Discussionmentioning

confidence: 99%

Pure large cell neuroendocrine carcinoma of the bladder without urological symptoms

Akdeniz¹,

Bakırtaş²,

Bolat³

et al. 2018

Pan Afr Med J

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“…The most common age of presentation is after the fifth and sixth decade, with nearly 80% of patients diagnosed after 50 years. Males are more commonly affected than females, with the male: female ratio of nearly 4:1 [ 3 ]. The typicalsymptom is hematuria, followed by lower urinary system symptoms [ 3 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Neuroendocrine carcinomas of the urinary bladder are rare tumors, estimated at less than 1% of urinary bladder malignancies [ 1 , 2 ]. They are mainly represented by small cell neuroendocrine carcinoma, while large cell neuroendocrine carcinoma (LCNEC) is rarely reported [ 1 , 3 ]. This manuscript, describes a large cell neuroendocrine carcinoma of the urinary bladder presenting with Paraplegia due to medullary compression caused by a metastasis.…”

Section: Introductionmentioning

confidence: 99%

Paraplegia due to medullary compression caused by a large cell neuroendocrine carcinoma of the urinary bladder: A case report

Tlili

Ammar

Majdoub

et al. 2021

Annals of Medicine &Amp; Surgery

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Background Neuroendocrine carcinomas of the urinary bladder are rare tumors, estimated at less than 1% of urinary bladder malignancies. They are mainly represented by small cell neuroendocrine carcinoma, while large cell neuroendocrine carcinoma (LCNEC) is rarely reported. Case presentation We report a case of a 49-year-old man presenting paraplegia caused by a metastatic urinary bladder LCNEC, which was managed with palliative external beam radiotherapy (EBRT) associated with MVAC chemotherapy, including methotrexate, vinblastine sulfate, doxorubicin hydrochloride (Adriamycin), and cisplatin. At the last follow-up of one year after his admission, there was a symptomatic improvement in the pain intensity. Conclusion LCNEC of the bladder was first described in 1986, and, until now, less than 40 cases have been published in the literature. To the best of our knowledge, this is the first case of primary LCNEC of the urinary bladder presenting with paraplegia.

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“…We believe that the present case is the 10th reported case of pure LCNEC of urinary bladder proven post-cystectomy [ 2 ]. The previous cases are summarized in Table 1 .…”

Section: Discussionmentioning

confidence: 99%

“…The majority of neuroendocrine carcinomas of the urinary bladder are small cell carcinomas. In recent years, a few cases of large cell neuroendocrine carcinomas (LCNEC) have also been reported [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

A case of large cell neuroendocrine carcinoma of the bladder with prolonged spontaneous remission

Chong

Zwi

Hanning

et al. 2017

Journal of Surgical Case Reports

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Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder are rare. We present a case of a 72-year-old man who presented with back pain and acute renal failure. Ultrasound showed a soft tissue mass in the base of the bladder causing bilateral ureteric obstruction. Subsequent biopsy of this mass demonstrated neuroendocrine carcinoma. He was commenced on neoadjuvant chemotherapy (carboplatin/etoposide) and proceeded to a radical cysto-prostatectomy. Histology revealed a LCNEC involving the bladder, T4a with invasion through to adipose tissue and posteriorly at perivesical resection margins. In addition, there was a Gleason score 9 prostatic adenocarcinoma, distinct from the neuroendocrine carcinoma. Following surgery, the patient developed gross local-regional recurrence and refused further systemic therapy. However, 1 year following referral to palliative care, a further CT-PET showed complete spontaneous remission of his disease. There are only few case reports of LCNEC of the urinary bladder therefore the pathogenesis and treatment protocol are still unclear. This case report highlights the unpredictable nature of this disease.

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“pure” primary large cell neuroendocrine carcinoma of the urinary bladder

Cited by 6 publications

References 14 publications

Pure large cell neuroendocrine carcinoma of the bladder without urological symptoms

Pure large cell neuroendocrine carcinoma of the bladder without urological symptoms

Paraplegia due to medullary compression caused by a large cell neuroendocrine carcinoma of the urinary bladder: A case report

A case of large cell neuroendocrine carcinoma of the bladder with prolonged spontaneous remission

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