Pure Red Cell Aplasia due to B19 Parvovirus Infection after Autologous Stem Cell Transplantation

Abstract

Parvovirus B19 is recognized as a rare cause of pure red cell aplasia (PRCA) in allogeneic stem cell (SCT) and solid organ transplant patients. We report a patient with Hodgkin's disease who developed PRCA due to parvovirus B19 after autologous SCT and who had an excellent response after treatment with gamma-globulin.

Precisione Treatment for Parvovirus B19 Infection After Hematopoietic Stem Cell Transplantation: a Case Report and Review of the Literature

“…The time of the onset of PVB19 disease range from 0.03 to 96 months after HSCT. Rash and cytopenia are the main manifestations of PVB19 infection (26/32 cases) [12][13][14][15][16], followed by other symptoms including arthralgia, malaise, headache, myalgia, and pruritus [17][18][19][20][21][22][23][24]. Four of the 32 patients developed organ failure involving the heart, the lungs, or the kidneys [21,24],among which three patients also had cytopenia.…”

Parvovirus B19 in the Context of Hematopoietic Stem Cell Transplantation: Evaluating Cell Donors and Recipients

“… 23 In a group of 201 patients after BM transplantation, the incidence of B19V infection was low (1.5%), and anemia was the main clinical manifestation observed. 62 Other few cases were also reported, 34 , 36 - 41 some of them linked to transmission by platelet transfusion, erythrocytes concentrate infusion or to acute infection. Therefore, although B19V appears to be transmitted by blood-derived products, hematopoietic allografts do not seem to be a source of frequent virus transmission.…”