Purification and characterization of a novel angiotensin I-converting enzyme inhibitory peptide derived from abalone (Haliotis discus hannai Ino) gonads

Wu, Qiang; Cai, Qiu-Feng; Tao, Zhipeng; Sun, Le-Chang; Shen, Jian-Dong; Zhang, Ling‐Jing; Cao, Min‐Jie

doi:10.1007/s00217-014-2315-8

Cited by 33 publications

(21 citation statements)

References 41 publications

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“…Journal Pre-proof angiotensin I-converting enzyme inhibitory activity with IC50 value of 106.24 μg/mL [541]. This activity remained after gastrointestinal digestion [541].…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Use of Alcalase in the production of bioactive peptides: A review

Tacias-Pascacio

Morellon‐Sterling

Siar

et al. 2020

International Journal of Biological Macromolecules

224

114

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Journal Pre-proof angiotensin I-converting enzyme inhibitory activity with IC50 value of 106.24 μg/mL [541]. This activity remained after gastrointestinal digestion [541].…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Use of Alcalase in the production of bioactive peptides: A review

Tacias-Pascacio

Morellon‐Sterling

Siar

et al. 2020

International Journal of Biological Macromolecules

224

114

View full text Add to dashboard Cite

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“…Digestion of R‐PE with GI proteinases was performed as previous described (Wu et al ., ). The characteristic of the final GID digest (GID) was further analysed.…”

Section: Methodsmentioning

confidence: 97%

“…The GID fraction was analysed for relative molecular weight distribution using a HPLC system (Agilent, Palo Alto, USA) in accordance with the method as described in Wu et al . (). The result was processed with the aid of GPC software (Agilent).…”

Section: Methodsmentioning

confidence: 97%

Effects of physicochemical factors and in vitro gastrointestinal digestion on antioxidant activity of R‐phycoerythrin from red algae Bangia fusco‐purpurea

Sun

et al. 2015

Int J of Food Sci Tech

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R-phycoerythrin (R-PE) was purified from the red algae Bangia fusco-purpurea after 35-50% ammonium sulphate fractionation followed by ion-exchange column chromatography on DEAE-Sepharose, resulting in a purity (A 565 /A 280 ) ratio of 5.1. The circular dichroism spectroscopy results suggested that the structure of R-PE is predominately helical. The antioxidant activity of R-PE was studied and revealed changes in conformation and antioxidant activity at different temperatures and pH values. After in vitro-simulated gastrointestinal (GI) digestion of R-PE, the scavenging activity of ABTS radical (EC 50 , 769.9 lg mL À1 ), DPPH radical (EC 50 , 421.9 lg mL À1 ), hydroxyl radical (EC 50 , 32.4 lg mL À1 ) and reducing power (A 700 = 0.5, 625.8 lg mL À1 ) were measured. Gel filtration chromatography analysis showed that the molecular weight distribution of the final GI digest that still contained high antioxidant activity was <3 kDa. Our present results indicate that digestion-resistant antioxidant peptides of R-PE may be obtained by in vitro GI proteinases degradation.

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“…Abalone viscera are reported to contain rich nutrients, whose protein content makes up a large percent. In previous studies, abalone viscera protein exhibited good properties for the production of bioactive peptides, including antioxidant peptides [3] and angiotensin I-converting enzyme inhibitory peptides [4] . It is of great importance to develop the new resource of abalone viscera protein.…”

Section: Introductionmentioning

confidence: 96%

Optimization of ultrasound assisted extraction of abalone viscera protein and its effect on the iron-chelating activity

Jia

Wen

et al. 2021

Ultrasonics Sonochemistry

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Highlights Ultrasound improves protein extraction rate by 16.56% than alkaline extraction. Ultrasound can affect iron-chelating peptide generation by protein extraction. Two alcalase hydrolysates own similar iron-chelating rate and binding sites. Main peptide sequences have different structural characteristic from each other.

show abstract

Purification and characterization of a novel angiotensin I-converting enzyme inhibitory peptide derived from abalone (Haliotis discus hannai Ino) gonads

Cited by 33 publications

References 41 publications

Use of Alcalase in the production of bioactive peptides: A review

Use of Alcalase in the production of bioactive peptides: A review

Effects of physicochemical factors and in vitro gastrointestinal digestion on antioxidant activity of R‐phycoerythrin from red algae Bangia fusco‐purpurea

Optimization of ultrasound assisted extraction of abalone viscera protein and its effect on the iron-chelating activity

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