Purification and Structural Determination of Hematopoietic Stem Cell-Stimulating Monoacetyldiglycerides from Cervus nippon (Deer Antler)

Effect of antler extract on corticosteroid-induced avascular necrosis of the femoral head in rats

“…Antler is an important traditional Chinese medicine, which contains many active components including free amino acids, polypeptides, trace elements, carbohydrates, hexosamines, mucopolysaccharides, uronic acids, sialic acids, prosta-glandins, glycolipids, phospholipids, nucleic acids, hypoxanthine, cholesterol, and cholesterol esters (Zhao et al, 1992;Ivankina et al, 1993;Yang et al, 2004a). Each spring, the hard antler from the previous season is cast off and the antler begins anew at incredible speed, revealing that the active compounds in antler can promote bone formation and growth.…”

Effects of TGFβ1 and extracts from Cervus korean TEMMINCK var. mantchuricus Swinhoe on acute and chronic arthritis in rats

“…N-Acetyl GM3 (Neu5Ac), Nglycolyl GM3 (Neu5Gc), and N-acetyl GD3 (Neu5Ac) were also present in the antler. The major ceramide moiety was composed of C16:0 or C22:0 fatty acids along with either C18 sphingosine or C20 eicosasphingosine (Yang et al, 2004). Many other substances including free amino acids, polypeptides, trace elements, carbohydrates, hexosamines, mucopolysaccharides, uronic acids, sialic acids, prostaglandins, glycolipids, phospholipids, nucleic acids, hypoxanthine, cholesterol, cholest-5-ene-3,7␣-diol, and cholesterol esters were also identified and claimed as the active components (Zhang et al, 1992;Zhao et al, 1992;Ivankina et al, 1993;Feng et al, 1995;Jhon et al, 1999;Yang et al, 2004).…”

Anti-bone resorption activity of deer antler aqua-acupunture, the pilose antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe (Nokyong) in adjuvant-induced arthritic rats

“…N-Acetyl GM3 (Neu5Ac), N-glycolyl GM3 (Neu5Gc), and N-acetyl GD3 (Neu5Ac) were present in the antler. The major ceramide moiety was composed of C16:0 or C22:0 fatty acids along with either C18 sphingosine or C20 eicosasphingosine (Yang et al, 2004). Many other substances from DAA have also been identified and claimed to contain active components, including free amino acids, polypeptides, trace elements, carbohydrates, hexosamines, mucopolysaccharides, uronic acids, sialic acids, prosta-glandins, glycolipids, phospholipids, nucleic acids, hypoxanthine, cholesterol, cholest-5-ene-3,7␣-diol, and cholesterol esters (Zhao et al, 1992;Jhon et al, 1999;Feng et al, 1995;Ivankina et al, 1993;Yang et al, 2004).…”