Purple corn extract (PCE) alleviates cigarette smoke (CS)-induced DNA damage in rodent blood cells by activation of AMPK/Foxo3a/MnSOD pathway

Kim, Wan-Sik; Kim, Chea-Ha; Lee, Jungmin; Jeon, Jeong-Ho; Kang, Beom-Goo; Warkad, Madhuri Shende; Inci, Gozde; Suh, Hwal; Lim, Soon Sung; Kim, Sung‐Chan; Kim, Jaebong; Lee, Jae Yong

doi:10.1080/19768354.2021.1883734

Cited by 6 publications

(4 citation statements)

References 40 publications

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“…Among these AKT effectors, only FOXO was reported to regulate DNA damage response by natural product treatments ( Table 7 ). For example, purple corn extract reduces cigarette smoke-induced DNA damage to rodent blood cells by up-regulating FOX3a [ 457 ]. 6-Bromoindirubin-3′-oxime, a hemi-synthetic GSK3β inhibitor of indirubin derivative, inhibits DNA damage in fibroblasts [ 493 ].…”

Section: Natural Products Regulate Akt Effectors-modulated Cell Funct...mentioning

confidence: 99%

The Impact of Oxidative Stress and AKT Pathway on Cancer Cell Functions and Its Application to Natural Products

et al. 2022

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Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating several cell functions of cancer cells. Several natural products modulate both oxidative stress and AKT for anticancer effects. However, the impact of natural product-modulating oxidative stress and AKT on cell functions lacks systemic understanding. Notably, the contribution of regulating cell functions by AKT downstream effectors is not yet well integrated. This review explores the role of oxidative stress and AKT pathway (AKT/AKT effectors) on ten cell functions, including apoptosis, autophagy, endoplasmic reticulum stress, mitochondrial morphogenesis, ferroptosis, necroptosis, DNA damage response, senescence, migration, and cell-cycle progression. The impact of oxidative stress and AKT are connected to these cell functions through cell function mediators. Moreover, the AKT effectors related to cell functions are integrated. Based on this rationale, natural products with the modulating abilities for oxidative stress and AKT pathway exhibit the potential to regulate these cell functions, but some were rarely reported, particularly for AKT effectors. This review sheds light on understanding the roles of oxidative stress and AKT pathway in regulating cell functions, providing future directions for natural products in cancer treatment.

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Section: Natural Products Regulate Akt Effectors-modulated Cell Funct...mentioning

confidence: 99%

The Impact of Oxidative Stress and AKT Pathway on Cancer Cell Functions and Its Application to Natural Products

et al. 2022

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“…It is reported that smoking may induce HERV transcription in the human urothelium [ 50 ]. HERV-E4-1, HERV-T S71-TK1, and HERV-K HML-6 transcripts tend to increase in human epithelium from smokers and human dermal fibroblasts treated with smoker’s urine [ 51 ].…”

Section: Hervs In Urological Cancersmentioning

confidence: 99%

“…Computational workflow identifies more than 3,000 transcriptionally active HERVs within The Cancer Genome Atlas pancancer RNA-Seq database and indicates that HERV expression is significantly associated with clinical prognosis in several tumors, including clear cell renal cell carcinoma (ccRCC) [ 52 ]. HERV signatures associated with RIG-I-like signaling and retroviral antigen activation of adaptive immunity can predict ccRCC patient survival independent of clinical stages and molecular subtypes [ 51 ]. Potential ccRCC-specific HERV epitopes identified in ccRCC ribosome profiling dataset bind HLA in vitro, and MHC tetramer-positive T cells to the predicted epitopes are detected.…”

Section: Hervs In Urological Cancersmentioning

confidence: 99%

“…Syncytin-1 (SYN-1) and syncytin-2 (SYN-2) are products of HERV env genes, HERV-W1 and HERV-FRD, respectively [ 2 , 3 , 11 ]. Syn-1 and Syn-2 bind their respective receptors, ASCT-2 (sodium-dependent neutral amino acid transporter type 2, aka solute-linked carrier family A member 5 [SLC1A5]) and domain-containing protein 2a (MFSD2a) in human trophoblasts, inducing fusion of individual trophoblast cells into a multinucleated layer of syncytiotrophoblasts, which form an outer layer of placental villi and in direct contact with maternal blood flow [ 51 ]. Suppressyn (SUPYN) is a truncated ENV protein encoded by the HERVH48-1 env gene from a HERV-H family virus, which interferes with cell-cell fusion [ 132 , 133 ].…”

Section: Reproductionmentioning

confidence: 99%

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Human Endogenous Retroviruses: Friends and Foes in Urology Clinics

2022

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Human endogenous retroviruses (HERVs) are originated from ancient exogenous retroviruses, which infected human germ line cells millions of years ago. HERVs have generally lost their replication and retrotransposition abilities, but adopted physiological roles in human biology. Though mostly inactive, HERVs can be reactivated by internal and external factors such as inflammations and environmental conditions. Their aberrant expression can participate in various human malignancies with complex etiology. This review describes the features and functions of HERVs in urological subjects, such as urological cancers and human reproduction. It provides the current knowledge of the HERVs and useful insights helping practice in urology clinics.

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