Putative factors associated with molar incisor hypomineralisation: an epidemiological study

Sönmez, Hayriye; Yildirim, Gözde; Bezgin, Tuğba

doi:10.1007/s40368-013-0012-0

Cited by 53 publications

(104 citation statements)

References 27 publications

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“…Several other studies found associations between specific illnesses and MIH. A number of retrospective studies found an association with higher odds of MIH and early childhood fever, including both studies that adjusted for confounding (Fig. ).…”

Section: Resultsmentioning

confidence: 99%

Etiology of molar incisor hypomineralization – A systematic review

Silva

Scurrah

Craig

et al. 2016

Comm Dent Oral Epid

254

226

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Section: Resultsmentioning

confidence: 99%

Etiology of molar incisor hypomineralization – A systematic review

Silva

Scurrah

Craig

et al. 2016

Comm Dent Oral Epid

254

226

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“…However, the aetiology of MIH remains unclear [Alaluusua, 2010;Sönmez et al, 2013;Wuollet et al, 2014]. There are studies demonstrating a potential environmental contribution to MIH [Jan et al, 2007;Alaluusua, 2010;Souza et al, 2012;Loli et al, 2015;Oyedele et al, 2015] and other studies demonstrating evidence of the genetic influence on the occurrence of MIH [Jeremias et al, 2013b;Kühnisch et al, 2014].…”

mentioning

confidence: 99%

Family-Based Genetic Association for Molar-Incisor Hypomineralization

Jeremias

Pierri²,

Souza³

et al. 2016

Caries Res

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Despite some evidence of genetic and environmental factors on molar-incisor hypomineralization (MIH), its aetiology remains unclear. This family-based genetic association study aimed more comprehensively to investigate the genetic carriage potentially involved in MIH development. DNA was obtained from buccal cells of 391 individuals who were birth family members of 101 Brazilian nuclear families. Sixty-three single nucleotide polymorphisms (SNPs) were investigated in 21 candidate genes related to amelogenesis using the TaqMan™ OpenArray™ Genotyping platform. All SNPs were genotyped in 165 birth family members unaffected by MIH, 96 with unknown MIH status and 130 affected individuals (50.7% with severe MIH). Association analysis was performed by the transmission/disequilibrium test (TDT), and statistical results were corrected using the false discovery rate. Significant results were obtained for SNPs rs7821494 (FAM83H gene, OR = 3.7; 95% CI = 1.75-7.78), rs34367704 (AMBN gene, OR = 2.7; 95% CI = 1.16-6.58), rs3789334 (BMP2 gene, OR = 2.9; 95% CI = 1.34-6.35), rs6099486 (BMP7 gene, OR = 2.2; 95% CI = 1.14-4.38), rs762642 (BMP4 gene, OR = 2.3; 95% CI = 1.38-3.65), rs7664896 (ENAM gene, OR = 2.1; 95% CI = 1.19-3.51), rs1711399 (MMP20 gene, OR = 0.4; 95% CI = 0.20-0.72), rs1711423 (MMP20 gene, OR = 2.1; 95% CI = 1.18-3.61), rs2278163 (DLX3 gene, OR = 2.8; 95% CI = 1.26-6.41), rs6996321 (FGFR1 gene, OR = 2.7; 95% CI = 1.20-5.88), and rs5979395 (AMELX gene, OR = 11.7; 95% CI = 1.63-84.74). Through this family-based association study, we concluded that variations in genes related to amelogenesis were associated with the susceptibility to develop MIH. This result is in agreement with the multifactorial idea of the MIH aetiology, but further studies are necessary to investigate more thoroughly the factors that could influence MIH.

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“…5 In fact, the enamel formation stage during which MIH arises is not currently known and there is no evidence that determines its cause. 19 With prevention as a hard-to-reach goal, the efforts of clinicians and researchers should focus on early diagnosis and restorative treatments that may remain successful over time.…”

Section: Discussionmentioning

confidence: 99%

Modified glass ionomer and orthodontic band: An interim alternative for the treatment of molar incisor hypomineralization. A case report.

Orellana

Pérez

2017

J Oral Res

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Introduction: Molar incisor hypomineralization (MIH) is a developmental condition resulting in defects in the enamel characterized by demarcated opacities mainly affecting first permanent molars and occasionally permanent incisors in 1 of every 6 children worldwide. Affected molars have greater susceptibility to post eruptive breakdown, extensive caries and, in severe cases, are difficult to restore. When the MIH-affected molar presents severe crown destruction, it is necessary to perform an intermediate restoration to preserve the remaining dental structure in order to maintain occlusion, proper hygiene and periodontal health. The case of an 11-year-old patient with severe MIH is reported. The patient had extensive crown destruction by caries in tooth 1.6 without clinical or radiographic signs of pulp pathology. After an initial preventive intervention, enamel without dentin support and carious dentin were removed from tooth 1.6. Subsequently, crown restoration was performed with resin-modified glass ionomer, followed by the cementation of an orthodontic band. After 18 months of follow-up, the patient reported no pain or discomfort. The restoration was preserved intact, maintaining occlusal functionality, pulp and gingival health. Conclusion: The interim treatment, cementing an orthodontic band over a tooth restored with glass ionomer seems to favor retention and compressive strength, keeping the MIH-affected molar asymptomatic for at least 18 months. Further studies evaluating this treatment option in similar clinical situations are recommended.

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Putative factors associated with molar incisor hypomineralisation: an epidemiological study

Abstract: The aetiology of MIH is not clear yet, and the results of this study support the results of previous studies regarding the putative causal effect of several factors.

Cited by 53 publications

References 27 publications

Etiology of molar incisor hypomineralization – A systematic review

Etiology of molar incisor hypomineralization – A systematic review

Family-Based Genetic Association for Molar-Incisor Hypomineralization

Modified glass ionomer and orthodontic band: An interim alternative for the treatment of molar incisor hypomineralization. A case report.

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