Putting attention in the spotlight: The influence of APOE genotype on visual search in mid adulthood

Lancaster, Claire; Forster, Sophie; Tabet, Naji; Rusted, Jennifer

doi:10.1016/j.bbr.2017.07.015

Cited by 15 publications

(15 citation statements)

References 52 publications

(87 reference statements)

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“…Recently, it has been shown that younger carriers of ε 2 allele have more gray matter in the hippocampus and rely more on hippocampal-dependent strategies in tasks of navigation than noncarriers (Konishi et al., 2016). In contrast, other studies have found performance disadvantages in attention-related tasks in ε 2 carriers in middle and old age, compared with ε 3 carriers (Lancaster et al., 2016, Lancaster et al., 2017). Considering these complicated effects of the APOE ε 2 allele on cognitive performance, future studies should aim to examine the role of all APOE alleles on behavior, across aging, to provide a more comprehensive phenotypical description of this gene on behavior and its relationship with AD.…”

Section: Discussioncontrasting

confidence: 57%

Dissociable effects of the apolipoprotein-E (APOE) gene on short- and long-term memories

Zokaei

Čepukaitytė

Board

et al. 2019

Neurobiology of Aging

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Short- and long-term memory performance as a function of apolipoprotein-E (APOE) genotype was examined in older, healthy individuals using sensitive and comparable tasks to provide a more detailed description of influences of the ε4 allele (highest genetic risk factor for Alzheimer's disease) on memory. Older heterozygous and homozygous ε4 carriers and noncarriers performed 2 tasks of memory. Both tasks allowed us to measure memory for item identity and locations, using a sensitive, continuous measure of report. Long-term memory for object locations was impaired in ε4/ε4 carriers, whereas, paradoxically, this group demonstrated superior short-term memory for locations. The dissociable effects of the gene on short- and long-term memory suggest that the effect of genotype on these two types of memories, and their neural underpinnings, might not be co-extensive. Whereas the long-term memory impairment might be linked to preclinical Alzheimer's disease, the short-term memory advantage may reflect an independent, phenotypical effect of this allele on cognition.

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Section: Discussioncontrasting

confidence: 57%

Dissociable effects of the apolipoprotein-E (APOE) gene on short- and long-term memories

Zokaei

Čepukaitytė

Board

et al. 2019

Neurobiology of Aging

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“…Also, the results may have been confounded by the presence of non-AD neuropathology more prevalent in older age. Moreover, recent work testing visuospatial attention in middle-aged adults, between the ages of 45 and 55, has found no impairment at this age in APOE4 carriers 33 .…”

Section: Introductionmentioning

confidence: 84%

Impaired memory-guided attention in asymptomatic APOE4 carriers

Zimmermann

Alain

Butler

2019

Sci Rep

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Attention and memory may be impaired in individuals at-risk for Alzheimer’s disease (AD), though standard cognitive assessments typically study the two in parallel. In reality, attention and memory interact to facilitate information processing, and thus a more integrative approach is required. Here, we used a novel auditory paradigm to assess how long-term memory for auditory scenes facilitates detection of an auditory target in asymptomatic carriers of Apolipoprotein E4 (APOE4), the principle risk gene for late-onset AD. We tested 60 healthy middle-aged adults with varying doses of APOE4 - 20 APOE4 homozygotes (E4/E4), 20 heterozygotes (E3/E4) and 20 non-carriers (E3/E3) - to determine effect on memory-guided attention. While explicit memory was unaffected by genotype, APOE4 dose significantly impaired memory-guided attention. A relationship between explicit memory and memory-guided attention was observed in non-carriers, but this correlation was not significant in E3/E4 and E4/E4 carriers, suggesting that APOE4 carriers rely less on explicit memory to facilitate attention. Since memory-guided attention declined with age in APOE4 homozygotes, this impairment may reflect early disease rather than being a life-long trait. In sum, asymptomatic individuals at increased genetic risk of AD show an age-dependent decline in attention-memory interaction when memory alone is not impaired.

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“…In this study, we explored the effects of APOE polymorphisms on cognitive performance in healthy aging adults. Different from other cross-section studies,15,36 we conducted a longitudinal study to explore the effects of APOE genotype on holistic and specific cognitive function (by using MMSE and NTB). Meanwhile, we also controlled variables that might affect cognitive results, such as age, sex, education, physical disease (such as hypertension and diabetes) as well as baseline scores of cognitive function.…”

Section: Discussionmentioning

confidence: 99%

<p>Short-term adverse effects of the apolipoprotein E ϵ4 allele over language function and executive function in healthy older adults</p>

Li¹,

Qiu²,

Sun³

et al. 2019

NDT

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Background: The 4 allele of the apolipoprotein E (APOE) gene is known as a risk factor for cognitive impairment. How APOE ε polymorphism affects the language and executive functions of healthy aging subjects remains less clear. Purpose: In this follow-up study, the relationship between APOE status and cognitive performance across various cognitive domains in healthy individuals (without dementia or mild cognitive impairment (MCI)) over 60 years old was investigated. Patients and methods: Based on multiplex amplification refractory mutation system polymerase chain reaction (PCR), 228 subjects (n=228; mean age: 70.59±8.07 years old; male %=40.8%) were divided into three groups, e2 (ε2/ε2 and ε2/ε3, n=35), e3 (ε3/ε3, n=152), and e4 (ε2/ε4, ε3/ε4, and ε4/ε4, n=41). Results: There was no statistical difference ( p >0.05) in the general demographic data and neuropsychological tests among the three groups on the baseline; however, e4 group showed a greater drop rate ( p <0.05) versus non-carriers on verbal fluency (e2: −0.043±0.221; e3: -0.081±0.239; e4: 0.069±0.329) and Webster picture completion (e2: 0.055±0.281; e3: 0.083±0.428; e4: 0.438±1.280) over the subsequent one year. Conclusion: The findings suggest that possession of the APOE ε 4 allele predicted a higher decline on tasks of language function and executive function in healthy elderly. And further research is required to determine whether strengthening the training of language function and executive function will delay the occurrence of cognitive impairment.

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Putting attention in the spotlight: The influence of APOE genotype on visual search in mid adulthood

Cited by 15 publications

References 52 publications

Dissociable effects of the apolipoprotein-E (APOE) gene on short- and long-term memories

Dissociable effects of the apolipoprotein-E (APOE) gene on short- and long-term memories

Impaired memory-guided attention in asymptomatic APOE4 carriers

<p>Short-term adverse effects of the apolipoprotein E ϵ4 allele over language function and executive function in healthy older adults</p>

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