PVA/PAA based electrospun nanofibers with pH-responsive color change using bromothymol blue and on-demand ciprofloxacin release properties

Arafat, M. Tarik; Mahmud, Musavvir; Wong, Siew Yee; Li, Xu

doi:10.1016/j.jddst.2020.102297

Cited by 30 publications

(29 citation statements)

References 44 publications

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Section: Ph-responsive Behaviormentioning

confidence: 99%

“…The response of polymers to pH is the most studied in drug delivery since there are significant pH changes within the human body at the organ, tissue, and cellular level (Arafat et al, 2021; Bazban‐Shotorbani et al, 2017). To give some examples, the gastrointestinal tract exhibits acidic pH in the stomach (pH 1.5–3.0), whereas more basic conditions are present in the small intestine (pH 7.0–8.0) and in the colon (pH 5.5–7.0) (Sosnik & Augustine 2016); healthy skin has a slightly acidic pH (5.5–6.5), which increases to alkaline values (higher than 7.4) when there is an infected chronic wound (Rahimi et al, 2016); the extracellular pH of normal cells is 7.4, but decreases to 6.8–7.0 for cancer cells (White et al, 2017).…”

Section: Stimuli‐responsive Electrospun Nanofibresmentioning

confidence: 99%

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Electrospinning of stimuli‐responsive polymers for controlled drug delivery: pH‐ and temperature‐driven release

Williams

Hatton

Willcock

et al. 2022

Biotech & Bioengineering

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Stimuli‐responsive polymers have attracted academic interest over the last 60 years due to their potential use in developing systems with a range of functionalities that can be activated by external artificial triggers. The diversity of responses and stimuli, which can be achieved through careful polymer selection and processing, opens up applications in nearly every sector. In particular, the use of responsive polymers for the controlled delivery of drugs and bioactive compounds has been heavily researched. This review provides an overview of the recent advancements in electrospinning of temperature‐ and pH‐responsive polymers to create networks of nanofibres with controlled drug delivery profiles for biomedical applications.

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Section: Ph-responsive Behaviormentioning

confidence: 99%

Section: Stimuli‐responsive Electrospun Nanofibresmentioning

confidence: 99%

Electrospinning of stimuli‐responsive polymers for controlled drug delivery: pH‐ and temperature‐driven release

Williams

Hatton

Willcock

et al. 2022

Biotech & Bioengineering

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“…On the other hand, many tissues or cell compartments have their own specific pH conditions for optimal functioning [49]. The acidic environment prevalent in tumor tissues can be used to selectively focus the release of anticancer medications at the tumor in response to pH variations via the use of pH-sensitive nanoformulations [96]. Treatment can begin when NFs adorned with targeting modules are manufactured using the electrospinning technique and filled with anticancer medication [97].…”

Section: Phmentioning

confidence: 99%

“…Arafat et al [96] examined the pH-responsive color change of PVA/PAA-based electrospun NFs with bromothymol blue (BTB) and on-demand ciprofloxacin release characteristics. The possibility of pH-responsive electrospun NFs with dual functionality of color change and on-demand drug delivery was demonstrated in their work.…”

Section: Phmentioning

confidence: 99%

On-Demand Drug Delivery Systems Using Nanofibers

2021

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On-demand drug-delivery systems using nanofibers are extensively applicable for customized drug release based on target location and timing to achieve the desired therapeutic effects. A nanofiber formulation is typically created for a certain medication and changing the drug may have a significant impact on the release kinetics from the same delivery system. Nanofibers have several distinguishing features and properties, including the ease with which they may be manufactured, the variety of materials appropriate for processing into fibers, a large surface area, and a complex pore structure. Nanofibers with effective drug-loading capabilities, controllable release, and high stability have gained the interest of researchers owing to their potential applications in on-demand drug delivery systems. Based on their composition and drug-release characteristics, we review the numerous types of nanofibers from the most recent accessible studies. Nanofibers are classified based on their mechanism of drug release, as well as their structure and content. To achieve controlled drug release, a suitable polymer, large surface-to-volume ratio, and high porosity of the nanofiber mesh are necessary. The properties of nanofibers for modified drug release are categorized here as protracted, stimulus-activated, and biphasic. Swellable or degradable polymers are commonly utilized to alter drug release. In addition to the polymer used, the process and ambient conditions can have considerable impacts on the release characteristics of the nanofibers. The formulation of nanofibers is highly complicated and depends on many variables; nevertheless, numerous options are available to accomplish the desired nanofiber drug-release characteristics.

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“…19,20 The fish spoilage is determined at approximately 43 h at room temperature, resulting in the film gradually changing color from yellow to green and then to blue. Other substrate such as polyaniline, 21 cellulose-based, 15,18,22 polyvinyl alcohol (PVA), [23][24][25] and chitosan 26,27 had also been used to show halochromic properties.…”

Section: Introductionmentioning

confidence: 99%

Halochromic PLA/PEG as real‐time solution and vapor sensing

Alias

Samsudin

Zubir

et al. 2022

J of Applied Polymer Sci

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In this study, halochromic sensor-based poly (lactic acid) (PLA) and polyethylene glycol (PEG) film as real-time sensing is successfully fabricated. Bromocresol purple (BCP) dye concentrations were varied (0.01 and 0.03 wt%/vol) in halochromic PLA/PEG film that changed its color from yellow to purple at a basic environment. The efficacy of the film with more BCP loading toward basic sensing was significant, where the material showed distinct color change with rapid response time. The color changes were proven by the CIE lab analysis, which showed that the initial and final colors of the indicator after interaction with PLA/PEG film are well above the limit for visual perception. The film response in base vapor was further determined by the amount of total volatile basic nitrogen (TVB-N) released from mackerel. The mackerel was kept at room temperature (26 ± 1 C) for 24 h and chiller temperature (3 ± 1 C) for 11 days. The threshold of food spoilage indicated by the TVB-N and the ΔE was reached at 18 h at room temperature when it started to deteriorate on Day 7 in the chiller. The findings suggest that a pH-sensor made of the PLA/PEG/BCP films is suitable for multiple applications, particularly in base solution and vapor sensing detection.

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PVA/PAA based electrospun nanofibers with pH-responsive color change using bromothymol blue and on-demand ciprofloxacin release properties

Cited by 30 publications

References 44 publications

Electrospinning of stimuli‐responsive polymers for controlled drug delivery: pH‐ and temperature‐driven release

Electrospinning of stimuli‐responsive polymers for controlled drug delivery: pH‐ and temperature‐driven release

On-Demand Drug Delivery Systems Using Nanofibers

Halochromic PLA/PEG as real‐time solution and vapor sensing

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